Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H36O3 |
| Molecular Weight | 360.5301 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C[C@@H](CC[C@]34C)OC(C)=O
InChI
InChIKey=GFHOQCXDABGYAL-MHFBBLOWSA-N
InChI=1S/C23H36O3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h16-21H,5-13H2,1-4H3/t16-,17+,18-,19+,20-,21-,22-,23+/m0/s1
| Molecular Formula | C23H36O3 |
| Molecular Weight | 360.5301 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/14640542 | https://www.ncbi.nlm.nih.gov/pubmed/27516905
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/14640542 | https://www.ncbi.nlm.nih.gov/pubmed/27516905
Allopregnan-3α-ol-20-one acetate (5α-Pregnan-3β-ol-20-one 3β-acetate) is a derivative of neurosteroid Allopregnanolone. Allopregnan-3α-ol-20-one acetate is an allosteric modulator of inhibitory γ-aminobutyric acid (GABA-A) receptors on neural stem cells and other cell types in the brain. Allopregnanolone acetate exerted moderate antidystonic effects and provoked a moderately reduced locomotor activity in animal models. Metabolic transformation of Allopregnan-3α-ol-20-one acetate leads Allopregnanolone. Allopregnanolone is in phase III trials for the treatment of super-refractory status epilepticus (SRSE) and postpartum depression, but Allopregnan-3α-ol-20-one acetate was never tested in clinical trials.
CNS Activity
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:25:24 GMT 2023
by
admin
on
Sat Dec 16 08:25:24 GMT 2023
|
| Record UNII |
0G0M7A1R8J
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| Record Status |
Validated (UNII)
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| Record Version |
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53835422
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0G0M7A1R8J
Created by
admin on Sat Dec 16 08:25:24 GMT 2023 , Edited by admin on Sat Dec 16 08:25:24 GMT 2023
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6003-24-3
Created by
admin on Sat Dec 16 08:25:24 GMT 2023 , Edited by admin on Sat Dec 16 08:25:24 GMT 2023
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