Showing 1 - 7 of 7 results
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
BX 471 is an oral nonpeptide chemokine receptor1 (CCR1) antagonist that was under clinical development with Bayer Healthcare Pharmaceuticals (formerly Bayer Schering Pharma AG and Berlex) for the treatment of various inflammation-related disorders, i...
Class (Stereo):
CHEMICAL (ACHIRAL)
CC-401 is a potent inhibitor of all three forms of c-Jun N-terminal Kinase (JNK) (Ki of 25 to 50 nM) and has at least 40-fold selectivity for JNK compared with other related kinases. Celgene was developing CC 401 for the treatment of cancer and infl...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
SB-202190 is a potent inhibitor of MAPK14 and MAPK11. It has been investigated in a number of preliminary cell-based studies including several cancer models. SB-202190 has been shown to be a UVB protectant; SB-202190 strongly inhibits UVB induced COX...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
GW-788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor. GW-788388 exhibits anti-fibrotic a...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins. Oleanolic acid protects the liver from acute chem...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
BX 471 is an oral nonpeptide chemokine receptor1 (CCR1) antagonist that was under clinical development with Bayer Healthcare Pharmaceuticals (formerly Bayer Schering Pharma AG and Berlex) for the treatment of various inflammation-related disorders, i...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins. Oleanolic acid protects the liver from acute chem...