U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C30H47O3.Na
Molecular Weight 478.6821
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM OLEANOLATE

SMILES

[Na+].[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C([O-])=O

InChI

InChIKey=QNELTPKHJFMSNK-RLFONNADSA-M
InChI=1S/C30H48O3.Na/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7;/h8,20-23,31H,9-18H2,1-7H3,(H,32,33);/q;+1/p-1/t20-,21-,22+,23-,27-,28+,29+,30-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C30H47O3
Molecular Weight 455.6924
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins. Oleanolic acid protects the liver from acute chemically induced liver injury, fibrosis and cirrhosis caused by chronic liver diseases. Its possess cytotoxic activity against tumor cell lines

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
PREVENTAGE FIRMING DEFENSE NORMAL/OILY BROAD SPECTRUM SPF 15 MERLE NORMAN

Approved Use

Unknown
Inactive ingredient
24 HOUR PIMPLE PUNISHER

Approved Use

For treatment of Acne. Helps keep skin clear of new acne blemishes.
Preventing
Unknown

Approved Use

Unknown
Secondary
Unknown

Approved Use

Unknown
Secondary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.
2000 Dec
Oleanane triterpenes from Junellia tridens.
2000 Dec
Eclalbatin, a triterpene saponin from Eclipta alba.
2001
Triterpene glycoside from Terminalia arjuna.
2001
Topical anti-inflammatory activity of Thymus willdenowii.
2001 Dec
Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity.
2001 Dec
Phytochemical and antimicrobial studies on Drynaria quercifolia.
2001 Dec
Studies on the constituents of Chenopodium quinoa seeds: isolation and characterization of new triterpene saponins.
2001 Feb
Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana.
2001 Jan
Effect of six compounds isolated from rhizome of Anemone raddeana on the superoxide generation in human neutrophil.
2001 Jan 26
In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B.
2001 Jun
Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart.
2001 Mar 20
Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.
2001 May
Antimycobacterial plant terpenoids.
2001 Nov
Superoxide- and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities of soyasaponin beta g related to gallic acid.
2001 Oct
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
2001 Oct
Nitric oxide and tumor necrosis factor-alpha production by oleanolic acid via nuclear factor-kappaB activation in macrophages.
2001 Oct 19
Acetylated triterpene saponins from the Thai medicinal plant, Sapindus emarginatus.
2001 Sep
Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.
2001 Sep 28
Gastroprotective activity of oleanolic acid derivatives on experimentally induced gastric lesions in rats and mice.
2002 Apr
Spasmolytic effects of baccharis conferta and some of its constituents.
2002 Jan
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.
2002 Jan 1
A multidisciplinary approach to the study of the fluminense vegetation.
2002 Mar
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products.
2002 Mar
Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography.
2002 Mar-Apr
RP-LC determination of oleane derivatives in Terminalia arjuna.
2002 May 15
Advancing the delivery of anticancer drugs: Conjugated polymer/triterpenoid composite.
2015 Jun
Patents

Sample Use Guides

Unknown
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 21:17:08 GMT 2023
Edited
by admin
on Fri Dec 15 21:17:08 GMT 2023
Record UNII
LVB19G8AUT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM OLEANOLATE
INCI  
INCI  
Official Name English
OLEAN-12-EN-28-OIC ACID, 3-HYDROXY-, MONOSODIUM SALT, (3.BETA.)-
Common Name English
OLEAN-12-EN-28-OIC ACID, 3-HYDROXY-, SODIUM SALT (1:1), (3.BETA.)-
Common Name English
URSOLIC ACID SODIUM SALT
Brand Name English
SODIUM OLEANOLATE [INCI]
Common Name English
Code System Code Type Description
PUBCHEM
49857633
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID30155138
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY
DAILYMED
LVB19G8AUT
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY
CAS
126309-42-0
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY
FDA UNII
LVB19G8AUT
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY
RXCUI
1366853
Created by admin on Fri Dec 15 21:17:08 GMT 2023 , Edited by admin on Fri Dec 15 21:17:08 GMT 2023
PRIMARY RxNorm
Related Record Type Details
PARENT -> SALT/SOLVATE