U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 25 results

Status:
US Approved Rx (1994)
First approved in 1959

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved c...
Status:
US Approved Rx (1974)
First approved in 1953

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Cyclopentolate (cyclopentolate hydrochloride) is a parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the accommodative muscl...
Status:
US Approved OTC
First approved in 1948

Class (Stereo):
CHEMICAL (RACEMIC)



Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug. Allergies are caused by an excessive type 1 hypersensitiv...
Status:
US Approved OTC
First marketed in 1934

Class (Stereo):
CHEMICAL (ABSOLUTE)



Phenylephrine is a powerful vasoconstrictor. It is used as a nasal decongestant and cardiotonic agent. Phenylephrine is a postsynaptic α1-receptor agonist with little effect on β-receptors of the heart. Parenteral administration of phenylephrine caus...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Enfenamic acid (under brand name tromaril) is an anthranilic acid derivative with potent anti-inflammatory, anti-arthritic, analgesic and antipyretic actions. It has additional unique property of anti-platelet aggregation activity, without disturbing...
Status:
US Previously Marketed
First marketed in 1935

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor s...
Status:
US Previously Marketed
First marketed in 1911

Class (Stereo):
CHEMICAL (EPIMERIC)



Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...
Status:
Possibly Marketed Outside US
First approved in 2021

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Acid green 50 (Lissamine Green B) is a synthetically produced organic acid dye with two aminophenyl groups. Acid green 50 is extensively used as a food dye and has a medical application as a staining agent. Due to its low toxicity and ability to stai...
Status:
Possibly Marketed Outside US
First approved in 2013

Class (Stereo):
CHEMICAL (ACHIRAL)



Rose bengal sodium (RB) is a small molecule, halogenated xanthene being developed by Provectus Biopharmaceuticals (formerly Provectus Pharmaceuticals). It is commonly used in eye drops to stain damaged conjunctival and corneal cells and thereby ident...
Status:
US Approved Rx (1994)
First approved in 1959

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved c...