Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.3529 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
InChI
InChIKey=BGDKAVGWHJFAGW-UHFFFAOYSA-N
InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/tropicamide.html
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/tropicamide.html
Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly.
CNS Activity
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
28.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32320311 |
0.5 % single, ocular dose: 0.5 % route of administration: Ocular experiment type: SINGLE co-administered: PHENYLEPHRINE |
TROPICAMIDE plasma | Oryctolagus cuniculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FED |
|
2.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8083562 |
400 μg single, ocular dose: 400 μg route of administration: Ocular experiment type: SINGLE co-administered: |
TROPICAMIDE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
25.1 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32320311 |
0.5 % single, ocular dose: 0.5 % route of administration: Ocular experiment type: SINGLE co-administered: PHENYLEPHRINE |
TROPICAMIDE plasma | Oryctolagus cuniculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
30 min |
unknown |
TROPICAMIDE unknown | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
55% |
TROPICAMIDE unknown | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Muscarinic binding sites of the pig intravesical ureter. | 1995 Oct |
|
| Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease. | 1996 Mar 22 |
|
| Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart. | 2001 May |
|
| Search of antimicrobial activity of selected non-antibiotic drugs. | 2002 Nov-Dec |
|
| Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill. | 2004 Jul 13 |
|
| Activation of muscarinic cholinergic receptors inhibits giant neurones in the caudal pontine reticular nucleus. | 2006 Oct |
|
| Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae. | 2008 Jan |
|
| Synergism Between Anticholinergic and Oxime Treatments Against Sarin-Induced Ocular Insult in Rats. | 2015 Aug |
Patents
Sample Use Guides
Usual Adult Dose for Refraction
Cycloplegic Refraction:
-Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes.
Comment:
-An additional drop may be given if the examination is not done within 20 to 30 minutes. Usual Adult Dose for Pupillary Dilation
Fundoscopy:
-Instill 1 or 2 drops of 0.5% solution into eye(s) 15 or 20 minutes prior to examination.
Comments:
-Heavily pigmented irides may require higher strength or more doses.
Usual Pediatric Dose for Refraction
Cycloplegic Refraction:
-Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes.
Route of Administration:
Topical
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C1937
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QS01FA06
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NCI_THESAURUS |
C29704
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WHO-ESSENTIAL MEDICINES LIST |
14.1
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N0000175574
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S01FA56
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S01BB01
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N0000175370
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S01FA06
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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TROPICAMIDE
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PRIMARY | Description: A white or almost white, crystalline powder. Solubility: Slightly soluble in water; freely soluble in dichloromethane R and ethanol (~750 g/l) TS. Category: Mydriatic. Storage: Tropicamide should be kept in a tightly closed container, protected from light. Labelling: The designation Tropicamide for sterile non-injectable use indicates that the substance complies with the additional requirement and may be used for sterile applications. Expiry date. Requirement: Tropicamide contains not less than 99.0% and not more than 101.0% of C17H20N2O2, calculated with reference to the dried substance. | ||
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216-140-2
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2774
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1699005
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N0A3Z5XTC6
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Tropicamide
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N0A3Z5XTC6
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10869
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C47776
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757372
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m11229
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DB00809
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Tropicamide
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100000091954
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1508-75-4
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
