Picilorex is an anorexic agent. Picilorex decreased food intake and body weight in mice and rats with experimental obesity. Triglycerides and cholesterol tended to remain at normal values in rats.

Flutemazepam is a benzodiazepine binding-site agonist and has hypnotic, anticonvulsant and anxiolytic activity. Flutemazepam was found very effective for the treatment of severe states of anxiety

Andolast is a small molecule activator of Calcium-activated potassium channels and an inhibitor of IgE-mediated anaphylaxis. Andolast is under investigation as an anti-asthmatic and for the treatment of COPD.

Esproquine is a tetrahydroisoquinoline derivative. It exerts positive inotropic effect and increases arterial pressure.

Ethonam is an antifungal compound. Its activity was evaluated in the treatment of chronic athlete's foot.

Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic. It intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin. Although it showed some clinical activity, the drug appeared to have no particular advantage over doxorubicin except for demonstrated activity against malignant melanoma. Unfortunately, detorubicin clearly has cardiac toxicity – in clinical trial, one patient developed congestive heart failure and other patients revealed endomyocardial biopsy evidence of cardiac toxicity.

Deriglidole was reported to inhibit alpha 2-adrenoceptors and ATP-sensitive K+ channels in mouse pancreatic B-cells, and to increase insulin release. The effects of deriglidole are stereoselective on alpha 2-adrenoceptors, but not on ATP-sensitive K+ channels of pancreatic B-cells. Deriglidole had been in phase II clinical trial for the treatment of diabetes mellitus type II in France. However, the study was discontinued.

Desmethylmoramide is a morpholinopyrrolidine. Being opioid receptor agonist it might be used as narcotic analgesic.

Talviraline (HBY 097) was developed as a nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (NNRTI) for the treatment of HIV Infections. Talviraline participated in a phase II clinical trial. It was found that the drug caused pronounced acute suppression of HIV-1 replication both in combination with zidovudine and alone. However, further development of the drug has been discontinued.