DERIGLIDOLE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C16H21N3
Molecular Weight	255.358
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1(CC2=CC=CC3=C2N1CC3)C4=NCCN4

InChI

InChIKey=BADQRNHAZHSOKC-UHFFFAOYSA-N

InChI=1S/C16H21N3/c1-2-7-16(15-17-8-9-18-15)11-13-5-3-4-12-6-10-19(16)14(12)13/h3-5H,2,6-11H2,1H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C16H21N3
Molecular Weight	255.358
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://adisinsight.springer.com/drugs/800000010 | https://www.ncbi.nlm.nih.gov/pubmed/7828647 | Kuhlmann, J., Puls, W. (2013) Oral Antidiabetics, page 661, retrieved from: https://books.google.ru/books?id=QpjsCAAAQBAJ

Deriglidole was reported to inhibit alpha 2-adrenoceptors and ATP-sensitive K+ channels in mouse pancreatic B-cells, and to increase insulin release. The effects of deriglidole are stereoselective on alpha 2-adrenoceptors, but not on ATP-sensitive K+ channels of pancreatic B-cells. Deriglidole had been in phase II clinical trial for the treatment of diabetes mellitus type II in France. However, the study was discontinued.

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:15 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:15 GMT 2023`
Record UNII	68EP8R4PMV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DERIGLIDOLE

Official Name

English

(+)-1,2,4,5-TETRAHYDRO-2-(2-IMIDAZOLIN-2-YL)-2-PROPYLPYRROLO(3,2,1-HI)INDOLE

Systematic Name

English

deriglidole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713