PICILOREX

Details

Stereochemistry	MIXED
Molecular Formula	C14H18ClN
Molecular Weight	235.752
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1NC(CC1C2=CC=C(Cl)C=C2)C3CC3

InChI

InChIKey=PZJBWSQQDMRZHY-UHFFFAOYSA-N

InChI=1S/C14H18ClN/c1-9-13(8-14(16-9)11-2-3-11)10-4-6-12(15)7-5-10/h4-7,9,11,13-14,16H,2-3,8H2,1H3

HIDE SMILES / InChI

Molecular Formula	C14H18ClN
Molecular Weight	235.752
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: DOI: 10.1016/S0065-7743(08)60379-6 | https://www.ncbi.nlm.nih.gov/pubmed/990622 | https://www.drugfuture.com/chemdata/picilorex.html | https://apps.who.int/iris/bitstream/handle/10665/67830/WHO_EDM_QSM_2003.2.pdf

Picilorex is an anorexic agent. Picilorex decreased food intake and body weight in mice and rats with experimental obesity. Triglycerides and cholesterol tended to remain at normal values in rats.

Approval Year

PubMed

Title	Date	PubMed
Activity of anorectic drugs (Amphetamine), amfepramone and UP 507-O4) on two models of obesity in animals [proceedings].	1976 Nov	990622

Patents

Sample Use Guides

In Vivo Use Guide

8 mg/kg in mice and 4 mg/kg in rats for 12 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:19 GMT 2023`
Record UNII	S8K2JDR3NZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PICILOREX

Official Name

English

PICILOREX [MI]

Common Name

English

picilorex [INN]

Common Name

English

3-(P-CHLOROPHENYL)-5-CYCLOPROPYL-2-METHYLPYRROLIDINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29728