PICILOREX

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	MIXED
Molecular Formula	C14H18ClN
Molecular Weight	235.752
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PICILOREX

Structure Search

SMILES

CC1NC(CC1C2=CC=C(Cl)C=C2)C3CC3

InChI

InChIKey=PZJBWSQQDMRZHY-UHFFFAOYSA-N

InChI=1S/C14H18ClN/c1-9-13(8-14(16-9)11-2-3-11)10-4-6-12(15)7-5-10/h4-7,9,11,13-14,16H,2-3,8H2,1H3

HIDE SMILES / InChI

Description
Sources: DOI: 10.1016/S0065-7743(08)60379-6 | https://www.ncbi.nlm.nih.gov/pubmed/990622 | https://www.drugfuture.com/chemdata/picilorex.html | https://apps.who.int/iris/bitstream/handle/10665/67830/WHO_EDM_QSM_2003.2.pdf

Picilorex is an anorexic agent. Picilorex decreased food intake and body weight in mice and rats with experimental obesity. Triglycerides and cholesterol tended to remain at normal values in rats.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Activity of anorectic drugs (Amphetamine), amfepramone and UP 507-O4) on two models of obesity in animals [proceedings].	1976-11	990622

Patents

Patents

Sample Use Guides

In Vivo Use Guide

8 mg/kg in mice and 4 mg/kg in rats for 12 days

Route of Administration: Oral

Name

Type

Language

PICILOREX [MI]

Preferred Name

English

PICILOREX

Official Name

English

picilorex [INN]

Common Name

English

3-(P-CHLOROPHENYL)-5-CYCLOPROPYL-2-METHYLPYRROLIDINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29728

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Code System Code Type Description

EPA CompTox

DTXSID70866933

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INN

4569

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DRUG CENTRAL

3817

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SMS_ID

100000082473

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EVMPD

SUB09809MIG

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NCI_THESAURUS

C75116

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MERCK INDEX

m891

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Merck Index

FDA UNII

S8K2JDR3NZ

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WIKIPEDIA

Picilorex

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CAS

62510-56-9

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ChEMBL

CHEMBL2105225

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PUBCHEM

191657

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ACTIVE MOIETY


					S8K2JDR3NZ

PICILOREX

SALT/SOLVATE (PARENT)


					F1323995AL

PICILOREX HYDROCHLORIDE