HYDROXYOCTACOSANYL HYDROXYSTEARATE is an inactive component of REFISSA® (tretinoin cream, 0.05%), which is indicated as an adjunctive agent for use in the mitigation (palliation) of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin in patients who do not achieve such palliation using comprehensive skin care and sun avoidance programs.

In calcium pidolate, the calcium ion is bound to two molecules of pyrrolidone carboxylic acid that act as protein supports. None of the calcium salts currently employed therapeutically (chloride, carbonate, lactate, gluconate, glucoheptonate, gluconolactate, gluconogalactogluconate, lactobionate, etc.) contain a protein support. Calcium pidolate is the only drug in which the calcium is transported by a protein substrate that is directly assimilable and specific to the body's bony matrix. Calcium pidolate can help the body's own calcium in performing its two primary roles: in any adverse changes in bony tissue during its growth, during bone ageing or traumatic bone lesions, Calcium pidolate can provide both a protein framework and a mineral source, as regards various metabolic functions of calcium, calcium pidolate have demonstrated that the substance is perfectly absorbed and distributed throughout various tissues and that it stimulates numerous hormonal and metabolic activities. In the treatment of various forms of osteoporosis with calcium pidolate, it is used curatively.

Methyl salicylate 2-ethylbutyrate is an ester salicylic acid derivative found in plants, produced by esterification of salicylic acid with methanol. It is used in cosmetics for wintergreen fragrance and flavoring compositions, including perfumes, foods, beverages, candies, chewing gums and oral care products. It is also used as the active ingredient in topical anesthetics to promote relief of muscle and arthritis pain.

Troxerutin (TXN) is a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables. It inhibits the agglomeration of blood platelets and red blood cells; prevents thrombogenesis; protects endothelial cells; and enhances microcirculation. It possess anti-inflammatory and anti-apoptotic properties. Troxerutin protected different cell types (epithelial cells, fibroblasts and lymphocytes) against peroxyl radical-induced apoptosis, necrosis and mitotic death. It scavenged intracellular basal and inducible ROS levels and also restored depletion of intracellular GSH levels. Troxerutin might provide a safe and effective treatment for rhinorrhea in the common cold deserves systematic evaluation. The use of a mixture of troxerutin, diosmin and hesperidin is a safe and effective mean of managing symptoms of acute hemorrhoidal disease. Troxerutin is used for the treatment of chronic venous insufficiency.