U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 1468 results

Status:
US Previously Marketed
Source:
Nitric Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Nitric Acid U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.
Status:
US Previously Marketed
Source:
Sodium Cyanide U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Cyanide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
Potassium Sulphocyanate
(1921)
Source URL:
First marketed in 1921
Source:
Potassium Sulphocyanate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Gallic acid is a polyphenol found in a variety of foods and herbs. Several studies have shown thta gallic acid has neuroprotective and anti-oxidant properties and can be a promising candidate for the treatment of cancer, cardiovascular diseases, neurodegenerative disorders, fatty liver disease and many others. Gallic acid acts by protecting cells against oxidative damage caused by reactive species often encountered in biological systems including, hydroxyl, superoxide and peroxyl and the non-radicals, hydrogen peroxide and hypochlorous acid. However, its ability to induce apoptosis, is mainly associated with its prooxidant, rather than antioxidant behavior.
Status:
US Previously Marketed
Source:
Precipitated Manganese Dioxide U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Precipitated Manganese Dioxide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Manganese(IV) oxide, an inorganic compound, is used as a pigment as a reagent in organic synthesis. This compound is also used as a nanoparticle and has different applications. For example, fucoidan-coated manganese dioxide nanoparticles (Fuco-MnO₂-NPs) may potentiate the effects of radiation therapy via dual targeting of tumor hypoxia and angiogenesis and has the great clinical potential in the treatment of hypoxic, radioresistant pancreatic cancer. Multifunctional hyaluronic acid-MnO2 nanoparticles (HA-MnO2 NPs) can be used for sensitive, targeted magnetic resonance imaging detection of gliomas and simultaneous attenuation of tumor hypoxia.
Status:
US Previously Marketed
Source:
Lead Iodide N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Lead Iodide N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


There is no information related to biological or pharmacological application of lead(II) bromide (a combustion product of the gasoline additives lead (IV) tetraethyl and 1,2-dibromoethane). It is only known, that this substance possesses mutagenicity.
Status:
US Previously Marketed
Source:
Wood Charcoal U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Wood Charcoal U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Conditions:

D&C Black #2 is the name, given by the FDA, for a highly pure form of carbon black prepared by combusting aromatic petroleum oil in the "oil furnace" process. It consists, essentially, of pure carbon. The Cosmetic, Toiletries and Fragrance Association (CTFA) petitioned the U.S. Food and Drug Administration (FDA) for approval to use carbon black in cosmetic formulations. The FDA granted approval on August 29, 2004, and now D&C Black #2 is used in all cosmetic products: mascaras, eyeliners, brush-on-brow, eyeshadows, and lipsticks.
Status:
US Previously Marketed
Source:
Strychnine Valerate N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Strychnine Valerate N.F.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
US Previously Marketed
Source:
Sugar U.S.P.
(1921)
Source URL:
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Sucrose is a disaccharide composed of glucose and fructose, and found in many plants and plant parts. Sucrose is often extracted and refined from either sugarcane or beet sugar for human consumption. Upon ingestion, sucrose is hydrolyzed in the small intestine by by sucrase to glucose and fructose. Sucrose is used as inactive ingredients in numerous drugs. In medicine, sucrose is used for pain relief in infants.
Status:
US Previously Marketed
Source:
DL-alpha tocopheryl acetate
(1921)
Source URL:
First marketed in 1921
Source:
DL-alpha tocopheryl acetate
Source URL:

Class (Stereo):
CHEMICAL (MIXED)



dl-α-tocopheryl phosphate has a growth acceleration effect on domestic fowl. Also was confirmed, that in all investigated animals dl-α-tocopheryl phosphate has an ability to being converted into vitamin E.