Sucrose

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H22O11
Molecular Weight	342.2965
Optical Activity	( + )
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O

InChI

InChIKey=CZMRCDWAGMRECN-UGDNZRGBSA-N

InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/sucrose
Curator's Comment: description was created based on several sources, including https://books.google.ru/books?id=spsD4WQbL0QC&pg=PA46&redir_esc=y#v=onepage&q&f=false | https://www.drugs.com/inactive/sucrose-74.html | http://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Sucrose_oral_for_procedural_pain_management_in_infants/

Sucrose is a disaccharide composed of glucose and fructose, and found in many plants and plant parts. Sucrose is often extracted and refined from either sugarcane or beet sugar for human consumption. Upon ingestion, sucrose is hydrolyzed in the small intestine by by sucrase to glucose and fructose. Sucrose is used as inactive ingredients in numerous drugs. In medicine, sucrose is used for pain relief in infants.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Starch and sucrose metabolism 1 Target ID: map00500 Sources: http://www.genome.jp/kegg-bin/show_pathway?hsa00500	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Sucrose_oral_for_procedural_pain_management_in_infants/	Preventing		Natural Metabolite	SWEET-EASE Approved Use Sucrose is to be used for relief of pain during minor procedures such as, but not limited to, heel stick or lance, venipuncture, IV insertion, naso or orogastric tube placement, intramuscular or subcutaneous injections, arterial punctures, eye exams, bladder catheterization, dressing changes, tape removal, suturing, arterial blood draw, and nasal or endotracheal tube suctioning. Use sucrose for additional pain relief in conjunction with other pharmacologic agents for procedures such as PICC or other line insertions, lumbar punctures, chest tube insertion/removal, circumcision block, and cut-down procedures.

PubMed

Title	Date	PubMed
Acute interferon-alpha administration modulates sucrose consumption in the rat.	2001 Apr	11166489
Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains.	2001 Apr 27	11152672
Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.	2001 Apr 6	11152681
Differences in DNA synthesis in vitro using isolated nuclei from regenerating livers of young and aged rats.	2001 Feb	11166354
Heparan sulfate: decoding a dynamic multifunctional cell regulator.	2001 Feb	11166215
The history of the "Davis Rig".	2001 Feb	11161349
The RNA structures engaged in replication and transcription of the A59 strain of mouse hepatitis virus.	2001 Feb	11161278
Trehalose and trehalase in Arabidopsis.	2001 Feb	11161063
Sucrose metabolism in plastids.	2001 Feb	11161049
Phloem loading in the tulip tree. Mechanisms and evolutionary implications.	2001 Feb	11161046
Sugar coordinately and differentially regulates growth- and stress-related gene expression via a complex signal transduction network and multiple control mechanisms.	2001 Feb	11161045
Maintaining methylation activities during salt stress. The involvement of adenosine kinase.	2001 Feb	11161043
Homeodomain leucine zipper proteins bind to the phosphate response domain of the soybean VspB tripartite promoter.	2001 Feb	11161037
Altered patterns of sucrose synthase phosphorylation and localization precede callose induction and root tip death in anoxic maize seedlings.	2001 Feb	11161016
The role of phosphorylation/dephosphorylation in agonist-induced desensitization of D1 dopamine receptor function: evidence for a novel pathway for receptor dephosphorylation.	2001 Feb	11160868
Pontine gustatory activity is altered by electrical stimulation in the central nucleus of the amygdala.	2001 Feb	11160511
Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae.	2001 Feb	11159431
Subcellular localization of bilirubin in rat brain after in vivo i.v. administration of [3H]bilirubin.	2001 Feb	11158514
Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial.	2001 Feb	11157370
The endoplasmic reticulum is a glucose-modulated high-affinity sink for Ca2+ in mouse pancreatic beta-cells.	2001 Feb 1	11158282
The Escherichia coli glucose transporter enzyme IICB(Glc) recruits the global repressor Mlc.	2001 Feb 1	11157755
Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore.	2001 Feb 2	11166286
Electrolytic lesions of the medial septum enhance latent inhibition in a conditioned taste aversion paradigm.	2001 Feb 2	11164800
Isolation of lectin and albumin from Pisum sativum var. macrocarpon ser. cv. sugar snap.	2001 Jan	11167136
High efficient production of Pr55(gag) virus-like particles expressing multiple HIV-1 epitopes, including a gp120 protein derived from an Ugandan HIV-1 isolate of subtype A.	2001 Jan	11166859
Analysis of anti-rotavirus activity of extract from Stevia rebaudiana.	2001 Jan	11166857
Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates.	2001 Jan	11166078
Fucosyled neoglycolipids: synthesis and interaction with a phospholipid.	2001 Jan	11163347
The control of single-celled cotton fiber elongation by developmentally reversible gating of plasmodesmata and coordinated expression of sucrose and K+ transporters and expansin.	2001 Jan	11158528
Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems.	2001 Jan	11158526
Technical advance: reduction of Fe(III)-chelates by mesophyll leaf disks of sugar beet. Multi-component origin and effects of Fe deficiency.	2001 Jan	11158448
Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium.	2001 Jan	11156589
A florigenic effect of sucrose in Fuchsia hybrida is blocked by gibberellin-induced assimilate competition.	2001 Jan	11154356
Assessing medical students' awareness of and sensitivity to diverse health beliefs using a standardized patient station.	2001 Jan	11154201
Selective expression of electrical correlates of differential appetitive classical conditioning in a feeding network.	2001 Jan	11152709
Analysis of taste mixtures by adults and children.	2001 Jan	11150062
Identification and characterization of a SET/NAP protein encoded by a brain-specific gene, MB20.	2001 Jan 1	11161794
Serine 187 is a crucial residue for allosteric regulation of Corynebacterium glutamicum 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase.	2001 Jan 1	11150666
Solvent accessibility studies on polysaccharides.	2001 Jan 10	11164230
The sugar-insensitive1 (sis1) mutant of Arabidopsis is allelic to ctr1.	2001 Jan 12	11162499
Mechanism of release of urinary Tamm-Horsfall glycoprotein from the kidney GPI-anchored counterpart.	2001 Jan 12	11162486
Leavening ability of baker's yeast exposed to hyperosmotic media.	2001 Jan 15	11164301
Intensity-dependent, rapid activation of presynaptic metabotropic glutamate receptors at a central synapse.	2001 Jan 15	11160453
Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation.	2001 Jan 15	11152662
Properties of human free apolipoprotein(a) and lipoprotein(a) after either freezing or lyophilization in the presence and absence of cryopreservatives.	2001 Jan 15	11152591
Technical optimisation of redispersible dry emulsions.	2001 Jan 16	11165077
Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.	2001 Jan 19	11163766
ITF expression in mouse brain during acquisition of alcohol self-administration.	2001 Jan 26	11164784
Effect of reduced flow on blood-brain barrier transport systems.	2001 Jan 26	11164767
Modulation of food intake by the kappa opioid U-50,488H: evidence for an effect on satiation.	2001 Jan 29	11164515

Sample Use Guides

In Vivo Use Guide

As a dietary supplement, sucrose is consumed orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

Sucrose

Official Name

English

GNE-410

Code

English

SUCROSE [EP MONOGRAPH]

Common Name

English

SUCROSE [VANDF]

Common Name

English

SUGAR, WHITE

Common Name

English

SUCROSE [EP IMPURITY]

Common Name

English

BEET SUGAR

Common Name

English

S-67F

Code

English

SUCROSE [NF]

Common Name

English

SUCROSE [II]

Common Name

English

SUCROSE [USP-RS]

Common Name

English

TABLE SUGAR

Common Name

English

D-SUCROSE

Common Name

English

SACCHAROSE

Common Name

English

SUCROSE (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]

Common Name

English

SUCROSE [JAN]

Common Name

English

NSC-406942

Code

English

SUCROSE [MI]

Common Name

English

.ALPHA.-D-GLUCOPYRANOSIDE, .BETA.-D-FRUCTOFURANOSYL-

Common Name

English

SACCHARUM OFFICINALE [HPUS]

Common Name

English

ROCK CANDY

Common Name

English

SUCROSE [HSDB]

Common Name

English

CANE SUGAR

Common Name

English

Sucrose [WHO-DD]

Common Name

English

SUGAR

Common Name

English

.BETA.-D-FRUCTOFURANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE

Common Name

English

(+)-SUCROSE

Common Name

English

SACCHARUM

Common Name

English

SACCHARUM OFFICINALE

Common Name

English

MICROSE

Common Name

English

SUGAR [VANDF]

Common Name

English

SUCROSE [FCC]

Common Name

English

WHITE SUGAR

Common Name

English

CONFECTIONER'S SUGAR

Common Name

English

SUCROSE [INCI]

Common Name

English

FROST SUGAR

Common Name

English

REFINED SUGAR

Common Name

English

Classification Tree Code System Code

LOINC

50916-6