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Details

Stereochemistry ACHIRAL
Molecular Formula HNO3
Molecular Weight 63.0128
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Nitric acid

SMILES

O[N+]([O-])=O

InChI

InChIKey=GRYLNZFGIOXLOG-UHFFFAOYSA-N
InChI=1S/HNO3/c2-1(3)4/h(H,2,3,4)

HIDE SMILES / InChI
Molecular Formula HNO3
Molecular Weight 63.0128
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Not Provided
504
MAXIMUM STRENGTH SENSITIVE TRUE MINT

Approved Use

builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact; helps protect against cavities.

Launch Date

1.25176316E12
PubMed

PubMed

TitleDatePubMed
Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine.
1982 Feb
[Acute and chronic cardiac decompensation: is vasodilator therapy useful?].
1982 Jan 14
Drug-induced torsade de pointes.
1985 Nov-Dec
Effects of amlodipine on myocardial infarction, infarct expansion, and ventricular geometry in the rat.
1992 Sep
Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells.
1996 Feb 5
Therapy of angina pectoris with long-acting nitrates: which agent and when?
1996 May
Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection.
1997 Jul-Aug
Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis.
1997 May
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide.
1997 May
The assimilatory nitrate reductase from the phototrophic bacterium, Rhodobacter capsulatus E1F1, is a flavoprotein.
1997 Sep 1
Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP.
1999 Jan 5
Diltiazem-mediated inhibition of sildenafil metabolism may promote nitrate-induced hypotension.
2000 Oct
Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture.
2001 Jun
Gallium nitrate accelerates partial thickness wound repair and alters keratinocyte integrin expression to favor a motile phenotype.
2002 Apr
Assessing nitrate metabolism in the intestinal tract by measuring breath nitric oxide and nitrous oxide, and its clinical significance.
2002 May 7
Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid.
2003
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
2005 Feb 1
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
2005 Jan 10
Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.
2005 Jul-Sep
Cl- interference with the epithelial Na+ channel ENaC.
2005 Sep 9
Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.
2008 Sep
Management of unusually extensive esophagogastric corrosive injuries: emergency measures and gastric reconstruction.
2009 May
The nitric acid burn trauma of the skin.
2010 Apr
Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.
2011 Jan
Patents

Patents

03931177
6
03957791
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03973039
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03978092
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03987186
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03988268
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03992446
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03994968
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04005219
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04010201
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04021479
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04036838
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04038405
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04049705
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04053479
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04055411
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04066651
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04066830
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04067993
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04071524
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04093446
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04096337
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04107315
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04118461
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04120899
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04126444
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04136192
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04141990
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04154941
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04159273
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04166119
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04174342
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04174397
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04177057
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04178387
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04180572
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04180679
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04196120
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04199586
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04200640
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04279918
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04415752
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04555386
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04604267
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04652559
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05292387
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05300511
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05616586
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05633248
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05739129
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05965679
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05972136
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06531502
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06972286
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07029504
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07495021
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08106064
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08394837
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08629277
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08735322
6
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:43:38 UTC 2023
Edited
by admin
on Fri Dec 15 15:43:38 UTC 2023
Record UNII
411VRN1TV4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Nitric acid
EP   HSDB   II   MART.   MI   WHO-DD  
Systematic Name English
NITRIC ACID 65%
Common Name English
NITRIC ACID [HSDB]
Common Name English
NITRIC ACID [MART.]
Common Name English
Nitric acid [WHO-DD]
Common Name English
NITRICUM ACIDUM [HPUS]
Common Name English
NITRIC ACID [EP MONOGRAPH]
Common Name English
NITRICUM ACIDUM
HPUS  
Common Name English
NITRIC ACID [II]
Common Name English
NITRIC ACID [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C802
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
EPA PESTICIDE CODE 45951
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1352
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
CHEBI
48107
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
WIKIPEDIA
NITRIC ACID
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
HSDB
1665
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
DAILYMED
411VRN1TV4
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
PUBCHEM
944
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
CAS
7697-37-2
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
MESH
D017942
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
SMS_ID
100000080017
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
EVMPD
SUB14657MIG
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
EPA CompTox
DTXSID5029685
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
RXCUI
1311391
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C28202
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
FDA UNII
411VRN1TV4
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-714-2
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY
MERCK INDEX
m7933
Created by admin on Fri Dec 15 15:43:38 UTC 2023 , Edited by admin on Fri Dec 15 15:43:38 UTC 2023
PRIMARY Merck Index
Related Record Type Details
Structure of Nitric acid
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