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Details

Stereochemistry ACHIRAL
Molecular Formula O.Pb
Molecular Weight 223.2
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEAD MONOXIDE

SMILES

[O--].[PbH2++]

InChI

InChIKey=MQZBBIXFDYLEGH-UHFFFAOYSA-N
InChI=1S/O.Pb.2H/q-2;+2;;

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Pb
Molecular Weight 207.2
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf

There is no information about biological application only a few articles about pharmacological application of lead fluoride, that this substance was investigated for topical dental caries.

CNS Activity

CNS Active
3913
Curator's Comment: Lead iodide may damage the nervous system.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
The effect of topical applications of lead fluoride on dental caries.
1947 Dec
The effect of topically applied fluorides on dental caries experience; report of findings with two, four and six applications of sodium fluoride and of lead fluoride.
1947 Oct 10
[Contribution to the study on allergy among workers exposed to lead oxide and lead sulfide].
1961 Jul-Dec
Microbial uptake of lead.
1972 Jun 23
Interaction of lead and bacterial lipids.
1975 May
Subacute effects of lead-oxide fumes in demolition workers.
1977 Jan 8
Abiotic factors affecting the toxicity of lead to fungi.
1979 Sep
Interconnection of activation volumes and activation enthalpies in cubic lead fluoride doped with alkali-metal cations.
1985 Jun 15
Lead oxide emissions--a case history.
1986
Mutagenic effects of lead (II) bromide.
1989 Dec
[The late effects of exposure to lead fluoride].
1992 Mar
Structural Chemistry of Poly(ethylene glycol) Complexes of Lead(II) Nitrate and Lead(II) Bromide.
1996 Nov 20
[Lead in the blood and protoporphyrin levels in erythrocytes in glass workers exposed to lead].
1997 Dec
Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups.
2008 Jul
The oxidative damage and inflammatory response induced by lead sulfide nanoparticles in rat lung.
2013 Oct
Autophagy plays a protective role in cell death of osteoblasts exposure to lead chloride.
2015 Dec 3
Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes.
2015 Mar
Rat Testis Damage Caused by Lead Sulfide Nanoparticles After Oral Exposure.
2016 Mar
Highly luminescent nanoscale quasi-2D layered lead bromide perovskites with tunable emissions.
2016 Mar 11
Patents

Patents

04024183
8
04096267
7
04182764
6
04212711
6
04324768
6
04927548
6
07208133
6
08106070
6
08318767
7
20050200803
6
20060110313
6
20100004280
6
20120088788
6
6498249
6
6933402
6
7118830
6
7550586
6
US2366953
6
US2448516
6
US3431182
6
US3716424
6

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
It was investigated the cytotoxicity of lead chloride in vitro cultured lymphocytes from human umbilical cord blood, using four monitoring methods namely, trypan blue staining, acridine orange/ethidium bromide staining, 3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyl tetrazolium bromide (MTT) and neutral red uptake assays; lead genotoxicity to lymphocytes was monitored by comet assay. The MIC value in each method was invariably 300 mg/L for PbCl2. Lethal concentration25 (LC25) values were almost in an agreeable range: 691.83 to 831.76 mg/L; LC50 values in each method were almost in the range: 1174.9 to 1348.9 mg/L; LC100 values were in the range: 3000 to 3300 mg/L, for lead chloride. The comet assay also indicated that the LC100 values were 3300 mg/L lead chloride. Thus, both cytotoxicity and genotoxicity were recorded at 3300 mg/L lead chloride with lymphocytes.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:38:31 GMT 2023
Edited
by admin
on Fri Dec 15 15:38:31 GMT 2023
Record UNII
4IN6FN8492
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LEAD MONOXIDE
MI   VANDF   WHO-DD  
Systematic Name English
LEAD MONOXIDE [MI]
Common Name English
PLUMBOUS OXIDE
Common Name English
Lead monoxide [WHO-DD]
Common Name English
MASSICOT
Common Name English
LITHARGE
Common Name English
LEAD OXIDE [HSDB]
Common Name English
LEAD MONOXIDE [VANDF]
Common Name English
LEAD(II) OXIDE
Systematic Name English
NSC-57634
Code English
Classification Tree Code System Code
EPA PESTICIDE CODE 48002
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
Code System Code Type Description
FDA UNII
4IN6FN8492
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
SMS_ID
100000077083
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
MESH
C047365
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
CHEBI
81045
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-267-0
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
CAS
1317-36-8
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
EVMPD
SUB14336MIG
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
HSDB
638
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
MERCK INDEX
m6738
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID0029638
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
PUBCHEM
159385
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
CAS
1335-25-7
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
GENERIC (FAMILY)
WIKIPEDIA
LEAD(II) OXIDE
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
NSC
57634
Created by admin on Fri Dec 15 15:38:31 GMT 2023 , Edited by admin on Fri Dec 15 15:38:31 GMT 2023
PRIMARY
NIH
NCATS
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