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Status:
US Previously Marketed
Source:
NYLMERATE BORIC ACID by HOLLAND-RANTDS
(1961)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
AMMONIUM BORATE is used in fireproofing wood and textiles, and also in electrolytic condensers. It can be indirect additive used in food contact substances.
Status:
US Previously Marketed
Source:
MERPECTOGEL PHENYLMERCURIC NITRATE by POYTHRESS
(1961)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.
Status:
US Previously Marketed
Source:
Hydrated Chloral U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Hydrated Chloral U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Chloral is a chlorinated aldehyde that found extensive use, beginning in the 1940s, as a precursor in the production of the insecticide DDT and, to a lesser extent, of other insecticides and pharmaceuticals. This use of chloral has declined steadily since the 1960s, especially in those countries where the use of DDT has been restricted. Chloral is readily converted to chloral hydrate in the presence of water. Chloral hydrate is used as a sedative before medical procedures and to reduce anxiety related to withdrawal from drugs. Wider exposure to chloral hydrate occurs at microgram-per-liter levels in drinking water and swimming pools as a result of chlorination. Chloral hydrate is a well-established aneuploidogenic agent that also has some mutagenic activity. In human cells in vitro, chloral hydrate induced aneuploidy, micronuclei and gene mutations. Chloral hydrate clearly induced micronuclei in Chinese hamster cells, whereas findings in mouse lymphoma cells were conflicting. Induction of somatic mutation (but not sex-linked mutation) by chloral hydrate was demonstrated in insects. Chloral hydrate is metabolized in vivo to trichloroethanol, which is responsible for its physiological and psychological effects. The metabolite of chloral hydrate exerts its pharmacological properties via enhancing the GABA receptor complex and therefore is similar in action to benzodiazepines, nonbenzodiazepines, and barbiturates. In clinical studies, oral chloral hydrate appears to have a lower sedation failure rate when compared with oral promethazine for children undergoing pediatric neurodiagnostic procedures. The sedation failure was similar for other comparisons such as oral dexmedetomidine, oral hydroxyzine hydrochloride, and oral midazolam. When compared with intravenous pentobarbital and music therapy, oral chloral hydrate had a higher sedation failure rate. Compared to dexmedetomidine, chloral hydrate was associated with a higher risk of nausea and vomiting.
Status:
US Previously Marketed
Source:
Stronger Pills of Iron, Quinine, Strychnine, and Arsenic N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Stronger Pills of Iron, Quinine, Strychnine, and Arsenic N.F.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Previously Marketed
Source:
Zinc Valerate U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Valeric acid is a colorless, oily liquid with an unpleasant odor. It is highly corrosive and must be handled with care. Valeric acid is mainly used as a chemical intermediate to manufacture flavors and perfumes, synthetic lubricants, agricultural chemicals, and pharmaceuticals. It is also used as a flavoring aid in foods. Valeric acid is considered safe as a food additive by the World Health Organization.
Status:
US Previously Marketed
Source:
Sodium Perborate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Perborate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Sodium perborate monohydrate is an inorganic sodium salt widely used in laundry detergents and in peroxide-based bleaches, such as tooth whitening products. It also has antiseptic and disinfectant properties and is therefore used as an oral debriding agent or oral wound cleanser.
Status:
US Previously Marketed
Source:
Corrosive Mercuric Chloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Corrosive Mercuric Chloride U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Potassium Triiodomercurate(II) is a periodometallate salt. It contains a triiodomercurate(1-). It is an antiseptic (topical) and disinfectant. It is also an antiseborrheic agent.
Status:
US Previously Marketed
Source:
Cotarnine Hydrochloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Cotarnine Hydrochloride U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
US Previously Marketed
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities.
Status:
US Previously Marketed
Source:
Solution of Lead Subacetate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Solution of Lead Subacetate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Lead(II) acetate is a white crystalline chemical compound with a sweetish taste. Lead(II) acetate is used as a mordant in textile printing and dyeing, as a drier in paints and varnishes, and in preparing other lead compounds. It was historically used as a sweetener and for cosmetics.