Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H5NO2 |
| Molecular Weight | 75.0666 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCON=O
InChI
InChIKey=QQZWEECEMNQSTG-UHFFFAOYSA-N
InChI=1S/C2H5NO2/c1-2-5-3-4/h2H2,1H3
| Molecular Formula | C2H5NO2 |
| Molecular Weight | 75.0666 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Ethyl nitrite is an alkyl nitrite and the main ingredient in a traditional ethanol-based South African remedy for colds and flu known as Witdulsies and sold in pharmacies. It is known as a traditional Afrikaans remedy and may have Dutch roots, as the same remedy is apparently made by the Germano-Dutch Amish people in the USA. However FDA has blocked over-the-counter sales of this same remedy, known in the USA as sweet nitrite or sweet spirit of nitre since 1980. Ethyl nitrite use has been associated with fatal methemoglobinemia and severe anoxic metabolic acidosis in infant
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Anesthetic experience of methemoglobinemia detected during general anesthesia for gastrectomy of advanced gastric cancer -A case report-. | 2010-11 |
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| Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. | 2010-07-15 |
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| Formation of nitric oxide, ethyl nitrite and an oxathiolone derivative of caffeic acid in a mixture of saliva and white wine. | 2010-03 |
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| Pathological basis of symptoms and crises in sickle cell disorder: implications for counseling and psychotherapy. | 2010-01-26 |
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| Nitric oxide and pulmonary hypertension. | 2010-01 |
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| Inclusion of a nitric oxide congener in the insufflation gas repletes S-nitrosohemoglobin and stabilizes physiologic status during prolonged carbon dioxide pneumoperitoneum. | 2009-12 |
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| Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols. | 2009-07-01 |
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| Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury. | 2009-04-29 |
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| Bench-to-bedside review: Inhaled nitric oxide therapy in adults. | 2009 |
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| The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. | 2008-08-15 |
|
| Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach. | 2008-07-15 |
|
| [Effect of ethyl nitrite versus inhaled nitric oxide in a rat model of acute pulmonary hypertension]. | 2008-06 |
|
| Isomeric recognition by ion/molecule reactions: the ionized phenol-cyclohexadienone case. | 2008-01 |
|
| Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution. | 2007-10-11 |
|
| Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. | 2007-08-01 |
|
| Inclusion of an S-nitrosylating agent in the insufflating gas does not alter gastric activity in rats following pneumoperitoneum. | 2007-08 |
|
| Efficacy of ethyl nitrite in reversing surgical vasospasm. | 2007-07 |
|
| Formation of ethyl nitrite in vivo after ethanol administration. | 2005-05-21 |
|
| A method to attenuate pneumoperitoneum-induced reductions in splanchnic blood flow. | 2005-02 |
|
| Fourier transform infrared-probed O(3P) microreactor: demonstration with ethylene reactions in argon matrix. | 2004-10 |
|
| The combined solid/solution-phase synthesis of nitrosamines: the evolution of the "libraries from libraries" concept. | 2003-01-10 |
|
| Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants. | 2002-12-31 |
|
| Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. | 2002-07-13 |
|
| Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics. | 2002-06-07 |
|
| Alcohol scavenges nitric oxide in gastric lumen. | 2002-05 |
|
| Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent. | 2001-06-07 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:14:22 GMT 2025
by
admin
on
Mon Mar 31 18:14:22 GMT 2025
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| Record UNII |
8C7CJ279RV
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| Record Status |
Validated (UNII)
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Code | English | ||
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CFR |
21 CFR 172.515
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1921585
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100000080000
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SUB14662MIG
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8C7CJ279RV
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ETHYL NITRITE
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C45678
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416
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C032712
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8C7CJ279RV
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CHEMBL1551365
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C83701
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m5155
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