The halogen bromine (Br2) is oxidant gas, and exposure to it presents a significant threat to public health. Br2 is widely used in the manufacture of medicinal compounds, agricultural chemicals, gasoline additives, dyes, photographic chemicals, etc. Br2 causes severe pulmonary and systemic injuries; however, the mechanisms of its toxicity is largely unknown. Br2 exposure has no specific antidote, and current treatments for patients exposed to Br2 are mainly supportive, including administration of supplemental oxygen, bronchodilators, and antibiotics in cases of infection. Assisted or supported ventilation with intubation and positive-pressure ventilation may also be necessary.