U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:06:36 GMT 2023
Edited
by admin
on Sat Dec 16 14:06:36 GMT 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
X6OG5T1C4M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1
Common Name English
SIG-1R
Common Name English
SR-BP
Common Name English
OPRS1
Common Name English
AGING-ASSOCIATED GENE 8 PROTEIN
Common Name English
SIGMAR1
Common Name English
SIGMA 1-TYPE OPIOID RECEPTOR
Common Name English
SIGMA1-RECEPTOR
Common Name English
SR31747-BINDING PROTEIN
Common Name English
Code System Code Type Description
UNIPROT
Q99720
Created by admin on Sat Dec 16 14:06:38 GMT 2023 , Edited by admin on Sat Dec 16 14:06:38 GMT 2023
PRIMARY
FDA UNII
X6OG5T1C4M
Created by admin on Sat Dec 16 14:06:38 GMT 2023 , Edited by admin on Sat Dec 16 14:06:38 GMT 2023
PRIMARY
Related Record Type Details
AGONIST -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
Selective ligand of sigma sites in brain, labelled with (+)-[3 H] 3PPP (K i= 5.3±0.3 nM), were investigated in rodents.
IC50
AGONIST -> TARGET
AGONIST -> TARGET
RADIOLIGAND->TARGET
IC50
INHIBITOR -> TARGET
IC50
AGONIST -> TARGET
(+)-pentazocine is active
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
Selective ligand of sigma sites in brain, labelled with (+)-[3 H] 3PPP (K i= 5.3±0.3 nM), were investigated in rodents.
IC50
INHIBITOR -> TARGET
Ki
RADIOLIGAND->TARGET
AGONIST -> TARGET
IC50
AGONIST -> TARGET
RADIOLIGAND->TARGET
>146,000-fold selectivity over the σ2R and >10,000-fold selectivity over 59 different targets
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
Ki
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL