Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H23NO2S |
Molecular Weight | 281.414 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCN1CCC(CC1)C2=CC=CC(=C2)S(C)(=O)=O
InChI
InChIKey=YGKUEOZJFIXDGI-UHFFFAOYSA-N
InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
Molecular Formula | C15H23NO2S |
Molecular Weight | 281.414 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including:
http://adisinsight.springer.com/drugs/800017494 | https://en.wikipedia.org/wiki/Pridopidine
Curator's Comment: description was created based on several sources, including:
http://adisinsight.springer.com/drugs/800017494 | https://en.wikipedia.org/wiki/Pridopidine
Pridopidine is an experimental drug candidate belonging to a class of agents known as dopidines, which act as dopaminergic stabilizers in the central nervous system. As a dopamine stabilizer, pridopidine is thought to reduce the effects of dopamine when there’s too much and increase its effects when there’s too little. Pridopidine, therefore, plays two opposing roles in the brain, which stabilize dopamine levels. In this way, pridopidine is thought to help the brain reestablish a normal balance of neurotransmitters, and thus regain control over motion. Pridopidine intended to treat Huntington’s disease movement symptoms. Pridopidine was well tolerated and had an adverse event profile similar to a placebo.
CNS Activity
Originator
Sources: https://eurekamag.com/research/035/869/035869096.php
Curator's Comment: https://www.google.ch/patents/US20100197712
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19919834 |
12.9 µM [IC50] | ||
70.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Cmax
Value | Dose | Co-administered | Analyte | Population |
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37.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
804 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
426 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
263 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
5141 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
54.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
3851 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
2365 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
13.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
8.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
TV-45065 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
9.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg 1 times / day steady-state, oral dose: 45 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
7.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26407011 |
45 mg single, oral dose: 45 mg route of administration: Oral experiment type: SINGLE co-administered: |
PRIDOPIDINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
PubMed
Title | Date | PubMed |
---|---|---|
The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat. | 2006 Aug |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00665223
45 mg once or twice daily for 26 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26094900
Administration of pridopidine (150 uM), the most effective dose, significantly reduced apoptosis in immortalized striatal knock-in cells expressing endogenous levels of mutant huntingtin and markedly enhanced phosphorylation state of prosurvival kinase ERK.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:37:42 GMT 2023
by
admin
on
Fri Dec 15 16:37:42 GMT 2023
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Record UNII |
HD4TW8S2VK
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Record Status |
Validated (UNII)
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FDA ORPHAN DRUG |
824621
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PRIDOPIDINE
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DB05371
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HD4TW8S2VK
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CHEMBL596802
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DTXSID90188225
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C483720
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m9130
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C170349
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100000132626
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SUB47886
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SALT/SOLVATE -> PARENT |
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