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Details

Stereochemistry ACHIRAL
Molecular Formula C15H23NO2S
Molecular Weight 281.414
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PRIDOPIDINE

SMILES

CCCN1CCC(CC1)C2=CC=CC(=C2)S(C)(=O)=O

InChI

InChIKey=YGKUEOZJFIXDGI-UHFFFAOYSA-N
InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C15H23NO2S
Molecular Weight 281.414
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pridopidine is an experimental drug candidate belonging to a class of agents known as dopidines, which act as dopaminergic stabilizers in the central nervous system. As a dopamine stabilizer, pridopidine is thought to reduce the effects of dopamine when there’s too much and increase its effects when there’s too little. Pridopidine, therefore, plays two opposing roles in the brain, which stabilize dopamine levels. In this way, pridopidine is thought to help the brain reestablish a normal balance of neurotransmitters, and thus regain control over motion. Pridopidine intended to treat Huntington’s disease movement symptoms. Pridopidine was well tolerated and had an adverse event profile similar to a placebo.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
12.9 µM [IC50]
70.0 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
263 ng/mL
45 mg single, oral
PRIDOPIDINE plasma
Homo sapiens
37.5 ng/mL
45 mg 1 times / day steady-state, oral
TV-45065 plasma
Homo sapiens
426 ng/mL
45 mg 1 times / day steady-state, oral
PRIDOPIDINE plasma
Homo sapiens
804 μg/mL
45 mg single, oral
TV-45065 plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
2365 ng × h/mL
45 mg single, oral
PRIDOPIDINE plasma
Homo sapiens
5141 ng × h/mL
45 mg 1 times / day steady-state, oral
TV-45065 plasma
Homo sapiens
3851 ng × h/mL
45 mg 1 times / day steady-state, oral
PRIDOPIDINE plasma
Homo sapiens
54.5 ng × h/mL
45 mg single, oral
TV-45065 plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
7.6 h
45 mg single, oral
PRIDOPIDINE plasma
Homo sapiens
13.6 h
45 mg 1 times / day steady-state, oral
TV-45065 plasma
Homo sapiens
9.6 h
45 mg 1 times / day steady-state, oral
PRIDOPIDINE plasma
Homo sapiens
8.5 h
45 mg single, oral
TV-45065 plasma
Homo sapiens

PubMed

Sample Use Guides

In Vivo Use Guide
45 mg once or twice daily for 26 weeks
Route of Administration: Oral
In Vitro Use Guide
Administration of pridopidine (150 uM), the most effective dose, significantly reduced apoptosis in immortalized striatal knock-in cells expressing endogenous levels of mutant huntingtin and markedly enhanced phosphorylation state of prosurvival kinase ERK.
Substance Class Chemical
Record UNII
HD4TW8S2VK
Record Status Validated (UNII)
Record Version