U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H8O6
Molecular Weight 176.1241
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ASCORBIC ACID

SMILES

[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

InChI

InChIKey=CIWBSHSKHKDKBQ-JLAZNSOCSA-N
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

HIDE SMILES / InChI

Molecular Formula C6H8O6
Molecular Weight 176.1241
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Ascorbic acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellow crystal or powder with a slight acidic taste. Ascorbic acid is an electron donor, and this property accounts for all its known functions. As an electron donor, ascorbic acid is a potent water-soluble antioxidant in humans. Ascorbic acid acts as an antioxidant under physiologic conditions exhibiting a cross over role as a pro-oxidant in pathological conditions. Oxidized ascorbic acid (dehydroascorbic acid (DHA) directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas ascorbic acid did not have this effect. These findings define a function for vitamin C in signal transduction other than as an antioxidant and mechanistically illuminate how vitamin C down-modulates NF-kappaB signaling. Vitamin C is recommended for the prevention and treatment of scurvy. Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid (vitamin c) is uncertain. Symptoms of mild deficiency may include faulty bone and tooth development, gingivitis, bleeding gums, and loosened teeth. Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increase the need for ascorbic acid (vitamin c). Hemovascular disorders, burns, delayed fracture and wound healing are indications for an increase in the daily intake.

CNS Activity

Curator's Comment: Ascorbic acid readily crosses the blood-brain barrier. Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. Neurodegenerative diseases typically involve high levels of oxidative stress and thus ascorbate has been posited to have potential therapeutic roles against ischemic stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Originator

Curator's Comment: In 1928, Albert Szent-Györgyi isolated a substance from adrenal glands that he called 'hexuronic acid'. Four years later, Charles Glen King isolated vitamin C in his laboratory and concluded that it was the same as 'hexuronic acid'. Norman Haworth deduced the chemical structure of vitamin C in 1933.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Vitamin C

Approved Use

Vitamin C is recommended for the prevention and treatment of scurvy. Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid (vitamin c) is uncertain. Symptoms of mild deficiency may include faulty bone and tooth development, gingivitis, bleeding gums, and loosened teeth. Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increase the need for ascorbic acid (vitamin c) . Hemovascular disorders, burns, delayed fracture and wound healing are indications for an increase in the daily intake
Preventing
Vitamin C

Approved Use

Vitamin C is recommended for the prevention and treatment of scurvy. Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid (vitamin c) is uncertain. Symptoms of mild deficiency may include faulty bone and tooth development, gingivitis, bleeding gums, and loosened teeth. Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increase the need for ascorbic acid (vitamin c) . Hemovascular disorders, burns, delayed fracture and wound healing are indications for an increase in the daily intake
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
33 mM
50 g/m² 1 times / day multiple, intravenous
dose: 50 g/m²
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
ASCORBIC ACID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
124 mM × h
50 g/m² 1 times / day multiple, intravenous
dose: 50 g/m²
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
ASCORBIC ACID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.8 h
50 g/m² 1 times / day multiple, intravenous
dose: 50 g/m²
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
ASCORBIC ACID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
15 mg/kg 2 times / day multiple, oral
Studied dose
Dose: 15 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 15 mg/kg, 2 times / day
Sources: Page: p.541
unhealthy, ADULT
n = 42
Health Status: unhealthy
Condition: Charcot-Marie-Tooth disease
Age Group: ADULT
Sex: M+F
Population Size: 42
Sources: Page: p.541
1.5 g/kg 3 times / week multiple, intravenous
Dose: 1.5 g/kg, 3 times / week
Route: intravenous
Route: multiple
Dose: 1.5 g/kg, 3 times / week
Sources: Page: p.414
unhealthy, ADULT
n = 15
Health Status: unhealthy
Condition: Non-small cell lung cancer
Age Group: ADULT
Sex: M+F
Food Status: FASTED
Population Size: 15
Sources: Page: p.414
Other AEs: Diarrhea...
Other AEs:
Diarrhea (grade 3, 6.7%)
Sources: Page: p.414
110 g/m2 1 times / day multiple, intravenous
Dose: 110 g/m2, 1 times / day
Route: intravenous
Route: multiple
Dose: 110 g/m2, 1 times / day
Sources: Page: p.143
unhealthy, ADULT
n = 3
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 3
Sources: Page: p.143
AEs

AEs

AESignificanceDosePopulation
Diarrhea grade 3, 6.7%
1.5 g/kg 3 times / week multiple, intravenous
Dose: 1.5 g/kg, 3 times / week
Route: intravenous
Route: multiple
Dose: 1.5 g/kg, 3 times / week
Sources: Page: p.414
unhealthy, ADULT
n = 15
Health Status: unhealthy
Condition: Non-small cell lung cancer
Age Group: ADULT
Sex: M+F
Food Status: FASTED
Population Size: 15
Sources: Page: p.414
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
moderate
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Vanadium and ascorbate effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase, cholesterol and tissue minerals in guinea pigs fed low-chromium diets.
1991-1992
Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats.
2000 Jul
Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia.
2000 Oct
Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins.
2002
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide.
2002 Nov 22
Search of antimicrobial activity of selected non-antibiotic drugs.
2002 Nov-Dec
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.
2003 Mar 14
Toluene diisocyanate exposure induces laryngo-tracheal eosinophilia, which can be ameliorated by supplementation with antioxidant vitamins in guinea pigs.
2003 Oct
Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization.
2003 Oct 15
Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
2004 Apr
Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease.
2004 Apr
Nelfinavir induces necrosis of 3T3F44-2A adipocytes by oxidative stress.
2004 Dec 15
Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species.
2004 Feb 29
Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults.
2004 Jun
Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells.
2004 Jun
Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.
2004 Mar 26
Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel.
2004 Mar 9
The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.
2005 Apr 8
[Effect of compound salvia injection on nitrate ester tolerance].
2005 Jan
Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)--induced oxidative damage in Leydig cells.
2005 Nov
Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment.
2006 Jan
Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase.
2006 Mar 17
Patents

Sample Use Guides

Ascorbic acid (vitamin c) is usually administered orally. When oral administration is not feasible or when malabsorption is suspected, the drug may be administered IM, IV, or subcutaneously. When given parenterally, utilization of the vitamin reportedly is best after IM administration and that is the preferred parenteral route. For intravenous injection, dilution into a large volume parenteral such as Normal Saline, Water for Injection, or Glucose is recommended to minimize the adverse reactions associated with intravenous injection. The average protective dose of vitamin C for adults is 70 to 150 mg daily. In the presence of scurvy, doses of 300 mg to 1 g daily are recommended. However, as much as 6 g has been administered parenterally to normal adults without evidence of toxicity. To enhance wound healing, doses of 300 to 500 mg daily for a week or ten days both preoperatively and postoperatively are generally considered adequate, although considerably larger amounts have been recommended. In the treatment of burns, doses are governed by the extent of tissue injury. For severe burns, daily doses of 1 to 2 g are recommended. In other conditions in which the need for vitamin C is increased, three to five times the daily optimum allowances appear to be adequate. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.
Route of Administration: Other
cell-derived decellularized extracellular matrix (dECM) with 250 µM of L-ascorbic acid phosphate (AA) treatment for 10 d had better rejuvenation in chondrogenic capacity if the deposited cells were from passage 2 rather than passage 5, despite no significant difference in matrix stiffness. In the dose regimen study, we found that dECMs deposited by varied concentrations of AA yielded expanded cells with higher proliferation capacity despite lower expression levels of stem cell related surface markers. Compared to cells expanded on tissue culture polystyrene, those on dECM exhibited greater chondrogenic potential, particularly for the dECMs with 50 µM and 250 µM of AA treatment. With the supplementation of ethyl-3,4-dihydroxybenzoate (EDHB), an inhibitor targeting procollagen synthesis, the dECM with 50 µM of AA treatment exhibited a dramatic decrease in the rejuvenation effect of expanded cell chondrogenic potential at both mRNA and protein levels despite no significant difference in matrix stiffness.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:21:10 GMT 2023
Edited
by admin
on Fri Dec 15 15:21:10 GMT 2023
Record UNII
PQ6CK8PD0R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASCORBIC ACID
EP   FCC   FHFI   HSDB   II   INCI   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN   INCI  
Official Name English
Ascorbic acid [WHO-DD]
Common Name English
ASCORBICUM ACIDUM
Common Name English
ASCORBATE
Common Name English
E-300
Code English
3-KETO-L-GULOFURANOLACTONE
Common Name English
ASCORBIC ACID [WHO-IP]
Common Name English
ASCORBICAP
Brand Name English
ASCORBIC ACID [JAN]
Common Name English
ASCOLTIN
Brand Name English
L-ASCORBIC ACID
Common Name English
VITAMIN C [VANDF]
Common Name English
ASCORBIC ACID [MI]
Common Name English
ASCORBIC ACID, L-
Common Name English
ASCORBIC ACID [HSDB]
Common Name English
NSC-218455
Code English
ACIDUM ASCORBICUM [WHO-IP LATIN]
Common Name English
INS-300
Code English
ASCORBIC ACID [FCC]
Common Name English
ASCORBIC ACID [ORANGE BOOK]
Common Name English
INS NO.300
Code English
ASCORBIC ACID [INCI]
Common Name English
ASCORBIC ACID [FHFI]
Common Name English
ASCORBIC ACID [II]
Common Name English
ASCORBIC ACID [USP MONOGRAPH]
Common Name English
ASCORBIC ACID [MART.]
Common Name English
ASCORBIC ACID [USP-RS]
Common Name English
L-ASCORBATE
Common Name English
2,3-DEHYDRO-L-THREO-HEXONO-1,4-LACTONE
Common Name English
VITAMIN C
VANDF  
Systematic Name English
ASCORBIC ACID [VANDF]
Common Name English
FEMA NO. 2109
Code English
NSC-33832
Code English
ASCORBIC ACID [EP MONOGRAPH]
Common Name English
(5R)-5-((1S)-1,2-DIHYDROXYETHYL)-3,4-DIHYDROXYFURAN-2(5H)-ONE
Systematic Name English
ASCOR
Brand Name English
VITAMIN C (AS ASCORBIC ACID)
Common Name English
ascorbic acid [INN]
Common Name English
Classification Tree Code System Code
LOINC 54351-2
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 34246-9
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-ATC S01XA15
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-VATC QG01AD03
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 1905-9
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 54350-4
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-ATC G01AD03
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 10 (Number of products:9521)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 12482-6
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 14622-5
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 56779-2
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 1902-6
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-ATC A11GA01
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
NCI_THESAURUS C275
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 3135 (Number of products:3731)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-ESSENTIAL MEDICINES LIST 27
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
NDF-RT N0000193618
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
JECFA EVALUATION INS-300
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
FDA ORPHAN DRUG 280909
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 1903-4
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 3428 (Number of products:24)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
EU-Orphan Drug EU/3/17/1832
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
CFR 21 CFR 862.1095
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-ATC A11GB01
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 2644 (Number of products:145)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
FDA ORPHAN DRUG 678719
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
NCI_THESAURUS C68507
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-VATC QA11GB01
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
FDA ORPHAN DRUG 645618
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 16408-7
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 15033-4
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-VATC QS01XA15
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
FDA ORPHAN DRUG 243707
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
CFR 21 CFR 101.78
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 6686-0
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
CFR 21 CFR 310.727
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 2886 (Number of products:101)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
DSLD 3376 (Number of products:376)
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 59398-8
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LIVERTOX NBK548448
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-300
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 34248-5
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 54385-0
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 34247-7
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
WHO-VATC QA11GA01
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
LOINC 1904-2
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
Code System Code Type Description
INN
372
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
FDA UNII
PQ6CK8PD0R
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-066-2
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
CAS
50-81-7
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
CHEBI
29073
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
DAILYMED
PQ6CK8PD0R
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
EVMPD
SUB05579MIG
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
EPA CompTox
DTXSID5020106
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
EVMPD
SUB127188
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
SMS_ID
100000086036
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
WIKIPEDIA
VITAMIN C
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
HSDB
818
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
CHEBI
176783
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
MESH
D001205
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
DRUG BANK
DB00126
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
769
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
NSC
218455
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL196
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
MERCK INDEX
m2089
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY Merck Index
RXCUI
1151
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY RxNorm
LACTMED
Vitamin C
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
NCI_THESAURUS
C285
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ASCORBIC ACID
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY Description: Colourless crystals or a white or almost white, crystalline powder; odourless or almost odourless. Solubility: Freely soluble in water; soluble in ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Antiscorbutic. Storage: Ascorbic acid should be kept in a tightly closed, non-metallic container, protected from light. Additional information: Ascorbic acid in solution deteriorates rapidly in contact with air; it has an acid taste. Even in the absenceof light, Ascorbic acid is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Definition: Ascorbic acid contains not less than 99.0% and not more than 100.5% of C6H8O6.
RXCUI
1370460
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
ALTERNATIVE
PUBCHEM
54670067
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
RS_ITEM_NUM
1043003
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
NSC
33832
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
CHEBI
38290
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
DRUG CENTRAL
4072
Created by admin on Fri Dec 15 15:21:10 GMT 2023 , Edited by admin on Fri Dec 15 15:21:10 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT ALWAYS PRESENT
ASSAY (TITRATION)
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
ENANTIOMER -> ENANTIOMER
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 89.2 mg (107%)
PARENT -> CONSTITUENT ALWAYS PRESENT
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE ACTIVE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
Related Record Type Details
ACTIVE MOIETY
http://apps.who.int/phint/pdf/b/Jb.6.1.35.pdf