Approval Year
| Substance Class |
Concept
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| Record UNII |
L47I8NT1WZ
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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L47I8NT1WZ
Created by
admin on Sat Dec 16 14:55:38 GMT 2023 , Edited by admin on Sat Dec 16 14:55:38 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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VACCINE ANTIGEN->TARGET | |||
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LIGAND->BINDER |
Exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils,
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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RADIOLIGAND->TARGET | |||
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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VACCINE ANTIGEN->TARGET |
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INHIBITOR OF AGGREGATION->TARGET |
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RADIOLIGAND->TARGET |
.beta.-amyloid plaques
Ki
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
Results: GSS patient showed obvious retention of (11C)BF-227 in the cerebellum, and lateral and medial temporal cortices. The three GSS patients showed significantly higher SUVRp
in the lateral temporal cortex, thalamus, and cerebellum (Figure) when compared to aged normal controls. Furthermore, when compared to the AD group, the GSS group showed significant elevation of SUVRp in the medial temporal cortex, thalamus, and cerebellum. Although 2 GSS patients showed retention of BF-227 in most brain regions, the youngest GSS patient showed BF-227 retention only in the cerebellum, thalamus, and medial temporal cortex, but not in the neocortex. Furthermore, 2 sporadic CJD patients showed no obvious BF-227 retention in any of the brain regions examined).
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SPECIFIED SUBSTANCE -> _ | |||
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INHIBITOR -> TARGET | |||
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RADIOLIGAND->TARGET |
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INDUCER -> TARGET |
Homozygous for increased risk of Alzheimer's disease. Biomarker
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| MOL_WEIGHT:WEIGHT AVERAGE | CHEMICAL |
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| Substance | Amount |
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