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Approval Year

Substance Class
Concept
Record UNII
L47I8NT1WZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUMAN .BETA.-AMYLOID PEPTIDE (1-42) PROTOFIBRILS
Common Name English
Code System Code Type Description
FDA UNII
L47I8NT1WZ
Created by admin on Sat Dec 16 14:55:38 UTC 2023 , Edited by admin on Sat Dec 16 14:55:38 UTC 2023
PRIMARY
Related Record Type Details
VACCINE ANTIGEN->TARGET
LIGAND->BINDER
Exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils,
INHIBITOR -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
RADIOLIGAND->TARGET
RADIOLIGAND->TARGET
VACCINE ANTIGEN->TARGET
INHIBITOR OF AGGREGATION->TARGET
RADIOLIGAND->TARGET
.beta.-amyloid plaques
Ki
RADIOLIGAND->TARGET
RADIOLIGAND->TARGET
Results: GSS patient showed obvious retention of (11C)BF-227 in the cerebellum, and lateral and medial temporal cortices. The three GSS patients showed significantly higher SUVRp in the lateral temporal cortex, thalamus, and cerebellum (Figure) when compared to aged normal controls. Furthermore, when compared to the AD group, the GSS group showed significant elevation of SUVRp in the medial temporal cortex, thalamus, and cerebellum. Although 2 GSS patients showed retention of BF-227 in most brain regions, the youngest GSS patient showed BF-227 retention only in the cerebellum, thalamus, and medial temporal cortex, but not in the neocortex. Furthermore, 2 sporadic CJD patients showed no obvious BF-227 retention in any of the brain regions examined).
SPECIFIED SUBSTANCE -> _
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
INDUCER -> TARGET
Homozygous for increased risk of Alzheimer's disease. Biomarker
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:WEIGHT AVERAGE CHEMICAL
Definition References