U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H11FN2O2
Molecular Weight 257.2503
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUTAFURANOL F-18

SMILES

CNC1=CC=C(C2=CC3=CC(O)=CC=C3O2)C([18F])=N1

InChI

InChIKey=MYNQXTDIPMCJCR-HUYCHCPVSA-N
InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)/i15-1

HIDE SMILES / InChI

Molecular Formula C14H11FN2O2
Molecular Weight 257.2503
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Flutafuranol F-18 (also known as NAV4694), a fluorine-18 labeled positron emission tomography (PET) imaging agent that was developed for diagnostic use. Flutafuranol F-18 binds to beta-amyloid deposits in the brain that could then be imaged in PET scans. It is known that amyloid plaque pathology is a required feature of Alzheimer’s disease (AD) and the presence of amyloid pathology is a supportive feature for the diagnosis of probable AD. Patients who are negative for amyloid pathology do not have AD. Thus, flutafuranol F-18 was studied in phase III clinical trial as an aid in the imaging for patients with Alzheimer’s disease and in phase II clinical trial for patients with mild cognitive impairment.

Approval Year

PubMed

PubMed

TitleDatePubMed
Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia.
2013 Jun
Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.
2016 Aug

Sample Use Guides

Intravenous [18F]NAV4694 radioactive dose 8.1 mCi(300 MBq) given once
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Thu Jul 06 07:46:11 UTC 2023
Edited
by admin
on Thu Jul 06 07:46:11 UTC 2023
Record UNII
785H5FQN20
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUTAFURANOL F-18
Common Name English
5-BENZOFURANOL, 2-(2-(FLUORO-18F)-6-(METHYLAMINO)-3-PYRIDINYL)-
Systematic Name English
NAV4694 F-18
Code English
(18F)NAV-4694
Code English
AZD4694 F-18
Code English
(18F)AZD-4694
Code English
Flutafuranol (18F) [WHO-DD]
Common Name English
2-[2-[18F]Fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol
Systematic Name English
(18F)NAV4694
Code English
(18F)AZD4694
Code English
FLUTAFURANOL F 18
USAN  
USAN  
Official Name English
FLUTAFURANOL F 18 [USAN]
Common Name English
AZD-4694 F-18
Code English
NAV-4694 F-18
Code English
flutafuranol (¹⁸F) [INN]
Common Name English
FLUTAFURANOL (18F)
INN   WHO-DD  
INN  
Official Name English
Code System Code Type Description
FDA UNII
785H5FQN20
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
NCI_THESAURUS
C171890
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
INN
10015
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
ChEMBL
CHEMBL2048308
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
CAS
1211333-21-9
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
USAN
AB-134
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
PUBCHEM
44815683
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
SMS_ID
100000175357
Created by admin on Thu Jul 06 07:46:11 UTC 2023 , Edited by admin on Thu Jul 06 07:46:11 UTC 2023
PRIMARY
Related Record Type Details
TARGET->RADIOLIGAND
Related Record Type Details
ACTIVE MOIETY