FLUTAFURANOL F-18

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H11FN2O2
Molecular Weight	257.2503
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC1=CC=C(C2=CC3=CC(O)=CC=C3O2)C([18F])=N1

InChI

InChIKey=MYNQXTDIPMCJCR-HUYCHCPVSA-N

InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)/i15-1

HIDE SMILES / InChI

Molecular Formula	C14H11FN2O2
Molecular Weight	257.2503
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.sec.gov/Archives/edgar/data/810509/000143774918004756/navb20171231_10k.htm | https://clinicaltrials.gov/ct2/show/NCT01886820

Flutafuranol F-18 (also known as NAV4694), a fluorine-18 labeled positron emission tomography (PET) imaging agent that was developed for diagnostic use. Flutafuranol F-18 binds to beta-amyloid deposits in the brain that could then be imaged in PET scans. It is known that amyloid plaque pathology is a required feature of Alzheimer’s disease (AD) and the presence of amyloid pathology is a supportive feature for the diagnosis of probable AD. Patients who are negative for amyloid pathology do not have AD. Thus, flutafuranol F-18 was studied in phase III clinical trial as an aid in the imaging for patients with Alzheimer’s disease and in phase II clinical trial for patients with mild cognitive impairment.

Originator

Approval Year

PubMed

Title	Date	PubMed
[The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium].	1992 Sep-Oct	1363945
Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia.	2013 Jun	23575995
Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.	2016 Aug	26912446
Implementing the centiloid transformation for (11)C-PiB and β-amyloid (18)F-PET tracers using CapAIBL.	2018 Dec	30130643
The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils.	2018 Jan-Dec	30213230

Sample Use Guides

In Vivo Use Guide

Intravenous [18F]NAV4694 radioactive dose 8.1 mCi(300 MBq) given once

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:27:50 GMT 2023` Edited by `admin` on `Sat Dec 16 01:27:50 GMT 2023`
Record UNII	785H5FQN20
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLUTAFURANOL F-18

Common Name

English

5-BENZOFURANOL, 2-(2-(FLUORO-18F)-6-(METHYLAMINO)-3-PYRIDINYL)-

Systematic Name

English

NAV4694 F-18

Code

English

(18F)NAV-4694

Code

English

AZD4694 F-18

Code

English

(18F)AZD-4694

Code

English

Flutafuranol (18F) [WHO-DD]

Common Name

English

2-[2-[18F]Fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol

Systematic Name

English

(18F)NAV4694

Code

English

(18F)AZD4694

Code

English

FLUTAFURANOL F 18

Official Name

English

FLUTAFURANOL F 18 [USAN]

Common Name

English

AZD-4694 F-18

Code

English

NAV-4694 F-18

Code

English

flutafuranol (¹⁸F) [INN]

Common Name

English

FLUTAFURANOL (18F)

Official Name

English

Code System Code Type Description

FDA UNII

785H5FQN20