Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H11FN2O2 |
| Molecular Weight | 257.2503 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC1=NC([18F])=C(C=C1)C2=CC3=C(O2)C=CC(O)=C3
InChI
InChIKey=MYNQXTDIPMCJCR-HUYCHCPVSA-N
InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)/i15-1
| Molecular Formula | C14H11FN2O2 |
| Molecular Weight | 257.2503 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Flutafuranol F-18 (also known as NAV4694), a fluorine-18 labeled positron emission tomography (PET) imaging agent that was developed for diagnostic use. Flutafuranol F-18 binds to beta-amyloid deposits in the brain that could then be imaged in PET scans. It is known that amyloid plaque pathology is a required feature of Alzheimer’s disease (AD) and the presence of amyloid pathology is a supportive feature for the diagnosis of probable AD. Patients who are negative for amyloid pathology do not have AD. Thus, flutafuranol F-18 was studied in phase III clinical trial as an aid in the imaging for patients with Alzheimer’s disease and in phase II clinical trial for patients with mild cognitive impairment.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Implementing the centiloid transformation for 11C-PiB and β-amyloid 18F-PET tracers using CapAIBL. | 2018-12 |
|
| The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils. | 2018-09-15 |
|
| Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale. | 2016-08 |
|
| Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia. | 2013-06 |
|
| [The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium]. | 1992-09-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:51:33 GMT 2025
by
admin
on
Mon Mar 31 20:51:33 GMT 2025
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785H5FQN20
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| Record Status |
Validated (UNII)
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| Related Record | Type | Details | ||
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