FIBT F-18

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16FN3OS
Molecular Weight	340.405
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC1=CC=C(C=C1)C2=CN3C(SC4=CC(OCC[18F])=CC=C34)=N2

InChI

InChIKey=WWPSVHYBUBUUFS-AWDFDDCISA-N

InChI=1S/C18H16FN3OS/c1-20-13-4-2-12(3-5-13)15-11-22-16-7-6-14(23-9-8-19)10-17(16)24-18(22)21-15/h2-7,10-11,20H,8-9H2,1H3/i19-1

HIDE SMILES / InChI

Molecular Formula	C18H16FN3OS
Molecular Weight	340.405
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:40:26 GMT 2023` Edited by `admin` on `Sat Dec 16 11:40:26 GMT 2023`
Record UNII	X763K4W3AA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FIBT F-18

Common Name

English

(18F)2-(P-METHYLAMINOPHENYL)-7-(2-FLUOROETHOXY)IMIDAZO(2,1-B)BENZOTHIAZOLE

Systematic Name

English

BENZENAMINE, 4-(7-(2-(FLUORO-18F)ETHOXY)IMIDAZO(2,1-B)BENZOTHIAZOL-2-YL)-N-METHYL-

Systematic Name

English

4-(7-(2-(FLUORO-18F)ETHOXY)IMIDAZO(2,1-B)BENZOTHIAZOL-2-YL)-N-METHYLBENZENAMINE

Systematic Name

English

(18F)IBT

Common Name

English

(18F)FIBT

Common Name

English

Code System Code Type Description

PUBCHEM

53494953

Created by admin on Sat Dec 16 11:40:26 GMT 2023 , Edited by admin on Sat Dec 16 11:40:26 GMT 2023

PRIMARY

FDA UNII

X763K4W3AA

Created by admin on Sat Dec 16 11:40:26 GMT 2023 , Edited by admin on Sat Dec 16 11:40:26 GMT 2023

PRIMARY

CAS

1240348-39-3

Created by admin on Sat Dec 16 11:40:26 GMT 2023 , Edited by admin on Sat Dec 16 11:40:26 GMT 2023

PRIMARY

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Amount:

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					X763K4W3AA

FIBT F-18

ACTIVE MOIETY

Comments:

The brain uptake kinetics of (18F)8 was compared to that of (11C)1a at 5 and 30 min post injection (Figure 1) in Balb-C mice (ng4). The measure of lipophilicity of (18F)8 was determined at pH 7.4: log Poct/PBS = 1.92 (n = 6). For comparison, the key preclinical data of a currently advancing 18F-labeled tracer for A.BETA., (18F)Florbetapir, were reportedly an in vitro binding affinity to A.BETA. aggregates in postmortem AD brain homogenates of 2.87 ( 0.17 nM, an initial uptake of 6.2% ID/g at 2 min pi and 1.84% ID/g at 60 min in male mice. The brain uptake kinetics measurements in Balb-C mice at 5 and 30 min pi of (18F)8 and (11C)1a show the desirable characteristics for an in vivo amyloid imaging agent with an excellent initial brain uptake and rapid clearance properties.

Amount: