Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H16FN3O2S |
| Molecular Weight | 332.381 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN([11CH3])C1=NC=C(S1)\C=C\C2=NC3=CC=C(OCCF)C=C3O2
InChI
InChIKey=GSZMUPHKOPBPPS-BOSKHGQCSA-N
InChI=1S/C16H16FN3O2S/c1-20(2)16-18-10-12(23-16)4-6-15-19-13-5-3-11(21-8-7-17)9-14(13)22-15/h3-6,9-10H,7-8H2,1-2H3/b6-4+/i1-1
| Molecular Formula | C16H16FN3O2S |
| Molecular Weight | 332.381 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 12:04:38 GMT 2023
by
admin
on
Sat Dec 16 12:04:38 GMT 2023
|
| Record UNII |
CI7PP08FLN
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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16040297
Created by
admin on Sat Dec 16 12:04:38 GMT 2023 , Edited by admin on Sat Dec 16 12:04:38 GMT 2023
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CI7PP08FLN
Created by
admin on Sat Dec 16 12:04:38 GMT 2023 , Edited by admin on Sat Dec 16 12:04:38 GMT 2023
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947602-44-0
Created by
admin on Sat Dec 16 12:04:38 GMT 2023 , Edited by admin on Sat Dec 16 12:04:38 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->RADIOLIGAND |
Results: GSS patient showed obvious retention of (11C)BF-227 in the cerebellum, and lateral and medial temporal cortices. The three GSS patients showed significantly higher SUVRp
in the lateral temporal cortex, thalamus, and cerebellum (Figure) when compared to aged normal controls. Furthermore, when compared to the AD group, the GSS group showed significant elevation of SUVRp in the medial temporal cortex, thalamus, and cerebellum. Although 2 GSS patients showed retention of BF-227 in most brain regions, the youngest GSS patient showed BF-227 retention only in the cerebellum, thalamus, and medial temporal cortex, but not in the neocortex. Furthermore, 2 sporadic CJD patients showed no obvious BF-227 retention in any of the brain regions examined).
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Results: Dementia with Lewy bodies (DLB) and Alzheimers disease (AD) patients exhibited an abnormal (11C)BF-227 retention in the neocortex compared with healthy control subjects. In DLB patients, (11C)BF-227 retention in the lateral temporal and posterior cingulate cortices was significantly higher than that in healthy controls. In addition, DLB patients showed significantly higher (11C)BF-227 uptake in the amygdala than healthy controls and AD patients.
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