U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C5H11NO2
Molecular Weight 117.1463
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VALINE

SMILES

CC(C)[C@H](N)C(O)=O

InChI

InChIKey=KZSNJWFQEVHDMF-BYPYZUCNSA-N
InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

HIDE SMILES / InChI

Molecular Formula C5H11NO2
Molecular Weight 117.1463
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including http://medical-dictionary.thefreedictionary.com/valine

Valine is an α-amino acid that is used in the biosynthesis of proteins. It is essential in humans, meaning the body cannot synthesize it and thus it must be obtained from the diet. There is a mixed scientivic evidence that as a dietary supplement valine improves training efficacy, delays central fatigue.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FREAMINE III 10%

Approved Use

Parenteral nutrition with 8.5% FreAmine® III (Amino Acid Injection) with Electrolytes is indicated to prevent nitrogen loss or treat negative nitrogen balance in adults and pediatric patients, where (1) the alimentary tract, by the oral, gastrostomy, or jejunostomy route, cannot or should not be used, or adequate protein intake is not feasible by these routes; (2) gastrointestinal absorption of protein is impaired; or (3) protein requirements are substantially increased as with extensive burns. Dosage, route of administration, and concomitant infusion of non-protein calories are dependent on various factors, such as nutritional metabolic status of the patient, anticipated duration of parenteral nutritional support, and vein tolerance

Launch Date

5.4431998E10
Preventing
Unknown

Approved Use

There is a mixed scientivic evidence that as a dietary supplement valine improves training efficacy, delays central fatigue.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
12.36 μg/mL
60 mg/kg single, oral
dose: 60 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
VALINE plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
40.3 μg × h/mL
60 mg/kg single, oral
dose: 60 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
VALINE plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.42 h
60 mg/kg single, oral
dose: 60 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
VALINE plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
PubMed

PubMed

TitleDatePubMed
Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).
2001
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.
2001
Multiple transport pathways for dibasic amino acids in the larval midgut of the silkworm Bombyx mori.
2001 Apr 27
Conformational preferences of heterochiral peptides. Crystal structures of heterochiral peptides Boc-(D) Val-(D) Ala-Leu-Ala-OMe and Boc-Val-Ala-Leu-(D) Ala-OMe--enhanced stability of beta-sheet through C-H...O hydrogen bonds.
2001 Feb
Evaluation of valine requirement of the commercial layer using a corn-soybean meal basal diet.
2001 Feb
Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury.
2001 Feb
Comparison of in vitro systems of protein digestion using either mammal or fish proteolytic enzymes.
2001 Feb
Renin-angiotensin system contribution to cardiac hypertrophy in experimental hyperthyroidism: an echocardiographic study.
2001 Feb
Do ACE inhibitors or ARBs limit restenosis after stenting? --assimilating the data.
2001 Feb
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2001 Feb
Sickle cell anemia and antisickling agents then and now.
2001 Feb
Transcriptional and translational regulation of calpain in the rat heart after myocardial infarction--effects of AT(1) and AT(2) receptor antagonists and ACE inhibitor.
2001 Feb
Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma.
2001 Feb
A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13.
2001 Feb
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
2001 Feb 1
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer.
2001 Feb 1
Angiotensin II type 1 receptor blockers.
2001 Feb 13
Reduction of nonpolar amino acids to amino alcohols to enhance volatility for high-precision isotopic analysis.
2001 Feb 15
Fragmentary form of thermostable leucine dehydrogenase of Bacillus stearothermophilus: its construction and reconstitution of active fragmentary enzyme.
2001 Feb 2
The dimerization motif of cytosolic sulfotransferases.
2001 Feb 9
Critical role of the residue size at position 87 in H2O2- dependent substrate hydroxylation activity and H2O2 inactivation of cytochrome P450BM-3.
2001 Feb 9
Novel fungal metabolites as cell wall active antifungals: fermentation, isolation, physico-chemical properties, structure and biological activity.
2001 Jan
Valine 77 of heterocystous ferredoxin FdxH2 in Anabaena variabilis strain ATCC 29413 is critical for its oxygen sensitivity.
2001 Jan
A silent mutation induces exon skipping in the phenylalanine hydroxylase gene in phenylketonuria.
2001 Jan
Reduction of wobble-position GC bases in Corynebacteria genes and enhancement of PCR and heterologous expression.
2001 Jan
Aseptic meningitis related to valacyclovir.
2001 Jan
V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression.
2001 Jan
Longitudinal analysis of varicella-zoster virus DNA on the ocular surface associated with herpes zoster ophthalmicus.
2001 Jan
Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase.
2001 Jan
Closely related HIV-1 CRF01_AE variant among injecting drug users in northern Vietnam: evidence of HIV spread across the Vietnam-China border.
2001 Jan 20
Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp.
2001 Jan 23
Protein control of the redox potential of the primary quinone acceptor in reactioncCenters from Rhodobacter sphaeroides.
2001 Jan 30
Fluorescence quenching properties and chemiluminescence responses of alpha-ketothiols derivatized with o-phthalaldehyde and primary amino compounds.
2001 Jan-Feb
[Neurologic toxicity caused by zelitrex (valaciclovir) in 3 patients with renal failure. Is overdose associated with improvement of product bioavailability improvement?].
2001 Mar
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
2001 Mar
Effect of valsartan on angiotensin II-induced plasminogen activator inhibitor-1 biosynthesis in arterial smooth muscle cells.
2001 Mar
Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences.
2001 Mar
Creutzfeldt-Jakob disease segregating in a three generation Danish family.
2001 Mar
Molecular anatomy and pathophysiologic implications of drug resistance in hepatitis B virus infection.
2001 Mar
Purification, characterization and cloning of isovaleryl-CoA dehydrogenase from higher plant mitochondria.
2001 Mar
The analgesic interaction between intrathecal clonidine and glutamate receptor antagonists on thermal and formalin-induced pain in rats.
2001 Mar
Ligand migration in human myoglobin: steric effects of isoleucine 107(G8) on O(2) and CO binding.
2001 Mar
Acute effects of peritoneal dialysis with dialysates containing dextrose or dextrose and amino acids on muscle protein turnover in patients with chronic renal failure.
2001 Mar
Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats.
2001 Mar
Influence of permeating ions on Kv1.5 channel block by nifedipine.
2001 Mar
Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease.
2001 Mar 13
Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis.
2001 Mar 16
NMDA-responsible, APV-insensitive receptor in cultured human astrocytes.
2001 Mar 2
The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.
2001 Mar 9
Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats.
2001 May
Patents

Sample Use Guides

Valine is administered with food or as a dietary supplement.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:32:20 UTC 2023
Edited
by admin
on Wed Jul 05 22:32:20 UTC 2023
Record UNII
HG18B9YRS7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VALINE
EP   HSDB   II   INCI   INN   MART.   MI   USAN   USP   VANDF   WHO-DD  
INN   INCI   USAN  
Official Name English
L-VALINE [JAN]
Common Name English
valine [INN]
Common Name English
L-VALINE [FCC]
Common Name English
VALINE [HSDB]
Common Name English
VALINE [USP MONOGRAPH]
Common Name English
VALINE [MART.]
Common Name English
LYSINE ACETATE IMPURITY D [EP IMPURITY]
Common Name English
VALINE [VANDF]
Common Name English
VAL
Common Name English
NSC-76038
Code English
VALINE [MI]
Common Name English
VALINE [EP MONOGRAPH]
Common Name English
L-VALINE [USP-RS]
Common Name English
(S)-2-AMINO-3-METHYLBUTANOIC ACID
Systematic Name English
VALINE [USAN]
Common Name English
L-VALINE
FCC   USP-RS  
Systematic Name English
VALINE [INCI]
Common Name English
VALINE [II]
Common Name English
Valine [WHO-DD]
Common Name English
Classification Tree Code System Code
LOINC 3119-5
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
DSLD 173 (Number of products:424)
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 9623-0
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 3118-7
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
DSLD 2406 (Number of products:2002)
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 26961-3
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 22692-8
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 32783-3
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 22729-8
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 53393-5
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 30064-0
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
NCI_THESAURUS C68442
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 44417-4
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 13822-2
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 32278-4
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LOINC 20661-5
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LOINC 22649-8
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LOINC 3117-9
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 26001-8
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LOINC 3120-3
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47800-8
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 41169-4
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 26873-0
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
FDA ORPHAN DRUG 93095
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47802-4
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47799-2
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47805-7
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LOINC 13419-7
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47803-2
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 56998-8
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 32279-2
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
CFR 21 CFR 172.320
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 3116-1
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 53151-7
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 25553-9
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47804-0
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
FDA ORPHAN DRUG 33588
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 47801-6
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
LOINC 26002-6
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
Code System Code Type Description
MESH
D014633
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
WIKIPEDIA
VALINE
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
CHEBI
57762
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
CAS
72-18-4
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
DAILYMED
HG18B9YRS7
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID40883233
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
EVMPD
SUB21995
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
FDA UNII
HG18B9YRS7
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
DRUG CENTRAL
4128
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
INN
6175
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-773-6
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
PUBCHEM
6287
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
RXCUI
11115
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY RxNorm
RS_ITEM_NUM
1708503
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
MERCK INDEX
M11365
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY Merck Index
EVMPD
SUB00008MIG
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
CHEBI
30015
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
SMS_ID
100000092422
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
DRUG BANK
DB00161
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
CHEBI
27266
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL43068
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
CHEBI
16414
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
HSDB
7800
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
NSC
76038
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
NCI_THESAURUS
C29604
Created by admin on Wed Jul 05 22:32:20 UTC 2023 , Edited by admin on Wed Jul 05 22:32:20 UTC 2023
PRIMARY
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impurity B at 570 nm
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ACTIVE MOIETY