VALINE

US Previously Marketed

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C5H11NO2
Molecular Weight	117.1463
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](N)C(O)=O

InChI

InChIKey=KZSNJWFQEVHDMF-BYPYZUCNSA-N

InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C5H11NO2
Molecular Weight	117.1463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugbank.ca/drugs/DB00161
Curator's Comment: description was created based on several sources, including http://medical-dictionary.thefreedictionary.com/valine

Valine is an α-amino acid that is used in the biosynthesis of proteins. It is essential in humans, meaning the body cannot synthesize it and thus it must be obtained from the diet. There is a mixed scientivic evidence that as a dietary supplement valine improves training efficacy, delays central fatigue.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
tryptophan transport 1 Target ID: GO:0015827 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16424144	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Burns 17 Sources: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=016822	Primary		Approved 8429	FREAMINE III 10% Approved Use Parenteral nutrition with 8.5% FreAmine® III (Amino Acid Injection) with Electrolytes is indicated to prevent nitrogen loss or treat negative nitrogen balance in adults and pediatric patients, where (1) the alimentary tract, by the oral, gastrostomy, or jejunostomy route, cannot or should not be used, or adequate protein intake is not feasible by these routes; (2) gastrointestinal absorption of protein is impaired; or (3) protein requirements are substantially increased as with extensive burns. Dosage, route of administration, and concomitant infusion of non-protein calories are dependent on various factors, such as nutritional metabolic status of the patient, anticipated duration of parenteral nutritional support, and vein tolerance Launch Date 1971
Central fatigue 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26785372	Preventing		Natural Metabolite	Unknown Approved Use There is a mixed scientivic evidence that as a dietary supplement valine improves training efficacy, delays central fatigue.

C_max

Value	Dose	Co-administered	Analyte	Population
12.36 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26119505/	60 mg/kg single, oral dose: 60 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		VALINE plasma	Canis lupus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
40.3 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26119505/	60 mg/kg single, oral dose: 60 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		VALINE plasma	Canis lupus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.42 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26119505/	60 mg/kg single, oral dose: 60 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		VALINE plasma	Canis lupus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:27266	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27266
ChemicalBook	CB5312867	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5312867
MolPort	MolPort-039-060-192	https://www.molport.com/shop/molecule-link/MolPort-039-060-192
eMolecules	514157	https://www.emolecules.com/cgi-bin/more?vid=514157

PubMed

Title	Date	PubMed
Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).	1999 Aug 20	10446133
An algorithm for mapping positively selected members of quasispecies-type viruses.	2001	11265061
Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).	2001	11235921
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.	2001	11178103
Efficacy and tolerability of angiotensin II type 1 receptor antagonists in dialysis patients using AN69 dialysis membranes.	2001	11174010
The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.	2001 Apr 27	11134027
Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury.	2001 Feb	11230374
Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats.	2001 Feb	11230314
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.	2001 Feb	11230310
Comparison of in vitro systems of protein digestion using either mammal or fish proteolytic enzymes.	2001 Feb	11223397
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.	2001 Feb	11173468
Sickle cell anemia and antisickling agents then and now.	2001 Feb	11172667
A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13.	2001 Feb	11156534
Extracellular amino acid profiles in the paraventricular nucleus of the rat hypothalamus are influenced by diet composition.	2001 Feb 23	11172779
The dimerization motif of cytosolic sulfotransferases.	2001 Feb 9	11172807
Critical role of the residue size at position 87 in H2O2- dependent substrate hydroxylation activity and H2O2 inactivation of cytochrome P450BM-3.	2001 Feb 9	11162663
Purification and characterization of two hemolysins from Stichodactyla helianthus.	2001 Feb-Mar	10978735
A silent mutation induces exon skipping in the phenylalanine hydroxylase gene in phenylketonuria.	2001 Jan	11214902
Reduction of wobble-position GC bases in Corynebacteria genes and enhancement of PCR and heterologous expression.	2001 Jan	11200224
Aseptic meningitis related to valacyclovir.	2001 Jan	11197578
Herpetic folliculitis and syringitis simulating acne excoriée.	2001 Jan	11176676
Longitudinal analysis of varicella-zoster virus DNA on the ocular surface associated with herpes zoster ophthalmicus.	2001 Jan	11162975
Net amino acid flux across the fetal liver and placenta during spontaneous ovine parturition.	2001 Jan	11150831
Genetic and biochemical analyses of a eukaryotic-like phospholipase D of Pseudomonas aeruginosa suggest horizontal acquisition and a role for persistence in a chronic pulmonary infection model.	2001 Jan	11136451
A (13)C NMR study on [3-(13)C]-, [1-(13)C]Ala-, or [1-(13)C]Val-labeled transmembrane peptides of bacteriorhodopsin in lipid bilayers: insertion, rigid-body motions, and local conformational fluctuations at ambient temperature.	2001 Jan	11072231
The basal turnover of yeast branched-chain amino acid permease Bap2p requires its C-terminal tail.	2001 Jan 15	11164310
Amino acid residues in ribonuclease MC1 from bitter gourd seeds which are essential for uridine specificity.	2001 Jan 16	11148047
Closely related HIV-1 CRF01_AE variant among injecting drug users in northern Vietnam: evidence of HIV spread across the Vietnam-China border.	2001 Jan 20	11177391
Mapping the energy surface for the folding reaction of the coiled-coil peptide GCN4-p1.	2001 Jan 23	11170389
Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC.	2001 Jan 5	11031260
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.	2001 Jan 5	11018042
Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi.	2001 Mar	11226452
Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats.	2001 Mar	11181633
Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis.	2001 Mar 16	11243831
Mechanism of pH-dependent photolysis of aliphatic amino acids and enantiomeric enrichment of racemic leucine by circularly polarized light.	2001 Mar 22	11263916
Catalytic asymmetric coupling of 2-naphthols by chiral tridentate oxovanadium (IV) complexes.	2001 Mar 22	11263903
The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.	2001 Mar 9	11238442

Patents

Sample Use Guides

In Vivo Use Guide

Valine is administered with food or as a dietary supplement.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:00:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:00:18 GMT 2023`
Record UNII	HG18B9YRS7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VALINE

Official Name

English

L-VALINE [JAN]

Common Name

English

valine [INN]

Common Name

English

L-VALINE [FCC]

Common Name

English

VALINE [HSDB]

Common Name

English

VALINE [USP MONOGRAPH]

Common Name

English

VALINE [MART.]

Common Name

English

LYSINE ACETATE IMPURITY D [EP IMPURITY]

Common Name

English

VALINE [VANDF]

Common Name

English

VAL

Common Name

English

NSC-76038

Code

English

VALINE [MI]

Common Name

English

VALINE [EP MONOGRAPH]

Common Name

English

L-VALINE [USP-RS]

Common Name

English

(S)-2-AMINO-3-METHYLBUTANOIC ACID

Systematic Name

English

VALINE [USAN]

Common Name

English

L-VALINE

Systematic Name

English

VALINE [INCI]

Common Name

English

VALINE [II]

Common Name

English

Valine [WHO-DD]

Common Name

English

Classification Tree Code System Code

LOINC

3119-5