CHLORIDE ION

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Cl
Molecular Weight	35.453
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M

InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8429	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 1971

PubMed

Title	Date	PubMed
Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents.	1999 Nov	10674923
Effect of vitamin E on aspirin-induced gastric mucosal injury in rats.	2000 Mar	10749339
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.	2001 Jun	11395602
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.	2001 Jun	11390426
Bile-induced adenosine triphosphate depletion and mucosal damage during reflux esophagitis.	2001 May	11346197
Serum SP-D is a marker of lung injury in rats.	2002 Apr	11880309
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.	2002 Aug	12212954
Effects of chemical and physical agents on viability and infectivity of Encephalitozoon intestinalis determined by cell culture and flow cytometry.	2002 Jun	12019139
c-Fos immunoreactivity in the brain after esophageal acid stimulation.	2003 Aug 18	12928072
Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach.	2003 Feb	12588467
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.	2004 Apr	15125461
Expression of a 72-kDa heat shock protein, and its cytoprotective function, in gastric mucosa in cirrhotic rats.	2004 Aug	15338365
Risk of acute bronchospasm and bronchial hyperreactivity from inhaled acid aerosol in healthy subjects: randomized, double-blind controlled trial.	2004 Dec	15578804
In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line.	2004 Feb	15046208
Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia.	2004 Jan	14750966
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice.	2004 Jul	15236176
Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam.	2004 Jun	15309881
Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury.	2004 Mar	15090967
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.	2004 Mar 19	15044056
Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.	2004 Nov 1	15331673
Esophageal ATP synthase and keratinocyte growth factor gene expression changes after acid and bile-induced mucosal damage.	2005 Apr	15883737
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.	2006 Jun	16755016
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.	2006 Nov	16984587
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.	2006 Oct 20	16945336
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.	2007 Oct	17714534
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.	2008 Jun	18534312
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.	2008 Sep	18617559
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.	2009 Aug	19644408
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.	2009 Jan	18594983
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.	2009 Oct	19566590
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.	2010	20380354
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.	2010 Nov 29	21114838
Altered sensorimotor responses to esophageal acidification in older adults with GERD.	2010 Oct	20545468

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:54 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:54 GMT 2023`
Record UNII	Q32ZN48698
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORIDE ION

Common Name

English

PERCHLORIDE

Common Name

English

CHLORIDE [VANDF]

Common Name

English

CHLORIDE

Systematic Name

English

CHLORIDE ANION

Common Name

English

Chloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68243