U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Cl
Molecular Weight 35.4529
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of CHLORIDE ION

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

3.83616E10
PubMed

PubMed

TitleDatePubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.
1982 Oct
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
1985 Aug
Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents.
1999 Nov
Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa.
1999 Nov
Effect of vitamin E on aspirin-induced gastric mucosal injury in rats.
2000 Mar
Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure: a possible model for sudden infant death syndrome.
2001 Aug
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
2001 Dec 7
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.
2001 Jun
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.
2001 Jun
Bile-induced adenosine triphosphate depletion and mucosal damage during reflux esophagitis.
2001 May
Serum SP-D is a marker of lung injury in rats.
2002 Apr
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.
2002 Feb
[The change of alveolar fluid clearance in acute lung injury rat].
2002 Jan
Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage.
2002 Jan 4
Effects of chemical and physical agents on viability and infectivity of Encephalitozoon intestinalis determined by cell culture and flow cytometry.
2002 Jun
Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat.
2003 Aug
Botulinum toxin type A may improve bladder function in a rat chemical cystitis model.
2003 Feb
Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats.
2003 May
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
2004 Apr
Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam.
2004 Jun
Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury.
2004 Mar
Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
2005
Pulmonary aspiration: new therapeutic approaches in the experimental model.
2005 Sep
Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem.
2005 Sep 14
Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.
2006 Feb
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
2006 Feb
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.
2007 Jul-Aug
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.
2007 Oct
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.
2008 Apr 23
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.
2008 Aug
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].
2008 Jun
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.
2008 Mar
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.
2008 May
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.
2008 Sep
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.
2009 Aug
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
2009 May
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
2010
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.
2010
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010 Aug
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
2010 Aug
NHE4 is critical for the renal handling of ammonia in rodents.
2010 Jun
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
2010 Oct
Altered sensorimotor responses to esophageal acidification in older adults with GERD.
2010 Oct
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.
2013 Dec 15
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.
2013 Feb
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:47:30 UTC 2021
Edited
by admin
on Sat Jun 26 01:47:30 UTC 2021
Record UNII
Q32ZN48698
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORIDE ION
Common Name English
PERCHLORIDE
Common Name English
CHLORIDE [VANDF]
Common Name English
CHLORIDE [WHO-DD]
Common Name English
CHLORIDE
VANDF   WHO-DD  
Systematic Name English
CHLORIDE ANION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68243
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LOINC 2075-0
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NCI_THESAURUS C597
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LOINC 51695-5
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LOINC 53640-9
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DSLD 37 (Number of products:1261)
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LOINC 2078-4
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CFR 21 CFR 862.1170
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Code System Code Type Description
EPA CompTox
16887-00-6
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PRIMARY
EVMPD
SUB32047
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PRIMARY
PUBCHEM
312
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PRIMARY
CAS
16887-00-6
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PRIMARY
DRUG BANK
DB14547
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PRIMARY
RXCUI
153974
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PRIMARY RxNorm
NCI_THESAURUS
C1741
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
FDA UNII
Q32ZN48698
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
WIKIPEDIA
Chloride
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
ASSAY (TITRATION)
USP
Related Record Type Details
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
TITRATION
USP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
Chlorides (2.4.4): maximum 100 ppm.
EP
PARENT -> IMPURITY
EP
Related Record Type Details
ACTIVE MOIETY