CHLORIDE ION

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Cl
Molecular Weight	35.453
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M

InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8360	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 3.83616E10

PubMed

Title	Date	PubMed
Effect of vitamin E on aspirin-induced gastric mucosal injury in rats.	2000 Mar	10749339
Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure: a possible model for sudden infant death syndrome.	2001 Aug	11510729
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.	2001 Jun	11395602
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.	2002 Feb	11850527
Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage.	2002 Jan 4	11837250
Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat.	2003 Aug	12853844
Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	2003 Jul	12646421
Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats.	2003 May	12771618
Microcirculatory changes in the canine oesophageal mucosa during experimental reflux oesophagitis: comparison of the effects of acid and bile.	2003 Oct	14621274
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.	2004 Apr	15125461
Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam.	2004 Jun	15309881
Pulmonary aspiration: new therapeutic approaches in the experimental model.	2005 Sep	16129981
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.	2006 Feb	16144966
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].	2006 Jun	16784557
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.	2007 Oct	17714534
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.	2008 Apr 23	18367213
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.	2008 Jun	18497604
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.	2008 Mar	18339021
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.	2008 May	18406487
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).	2009 Jul 15	19497430
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].	2009 Jun	19957777
Animal study for airway inflammation triggered by gastroesophageal reflux.	2009 Nov 20	19951613
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.	2010	20380354
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.	2010 Aug	20872349
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.	2010 Aug	20462967
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.	2010 Nov	20818264
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.	2010 Nov	20719974
Altered sensorimotor responses to esophageal acidification in older adults with GERD.	2010 Oct	20545468
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.	2010 Sep	20616304
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.	2013 Feb	22906572

Patents

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:53:04 UTC 2023` Edited by `admin` on `Wed Jul 05 23:53:04 UTC 2023`
Record UNII	Q32ZN48698
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORIDE ION

Common Name

English

PERCHLORIDE

Common Name

English

CHLORIDE [VANDF]

Common Name

English

CHLORIDE

Systematic Name

English

CHLORIDE ANION

Common Name

English

Chloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68243