Chloride ion

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Cl
Molecular Weight	35.453
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M

InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8583	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 1971

PubMed

Title	Date	PubMed
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.	2015-01-05	25478868
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.	2013-12-15	24144632
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.	2013-02	22906572
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.	2011-05	21339339
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells.	2011-02	21212935
The effect of tidal volume on systemic inflammation in Acid-induced lung injury.	2011	21311175
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.	2010-11-29	21114838
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.	2010-11	20818264
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.	2010-11	20719974
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.	2010-10	20719367
Altered sensorimotor responses to esophageal acidification in older adults with GERD.	2010-10	20545468
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.	2010-09	20616304
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.	2010-08	20872349
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.	2010-08	20597076
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.	2010-08	20462967
NHE4 is critical for the renal handling of ammonia in rodents.	2010-06	20484819
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.	2010	20516732
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.	2010	20380354
Animal study for airway inflammation triggered by gastroesophageal reflux.	2009-11-20	19951613
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.	2009-11	19760209
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.	2009-10	19566590
Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.	2009-09	19483072
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.	2009-08	19644408
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).	2009-07-15	19497430
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].	2009-06	19957777
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.	2009-06	19321595
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.	2009-05	19279288
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.	2009-04-01	19193631
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.	2009-04	19262391
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.	2009-03	19060228
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.	2009-02	19094174
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.	2009-01	18594983
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.	2008-09	18617559
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.	2008-08	18573544
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].	2008-06	18549715
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.	2008-06	18534312
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.	2008-06	18497604
TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.	2008-05-16	18331834
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.	2008-05	18406487
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.	2008-04-23	18367213
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.	2008-03	18339021
Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.	2008-02	18184328
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.	2007-10	17714534
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.	2007-09-01	17627983
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.	2007-07-14	17627322
Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.	2007-06-01	17363388
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.	1996-02	8601381
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.	1991-09	1887894
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.	1985-08	3865005
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.	1982-10	6218601

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:17 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:17 GMT 2025`
Record UNII	Q32ZN48698
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORIDE

Preferred Name

English

Chloride ion

Common Name

English

PERCHLORIDE

Common Name

English

CHLORIDE [VANDF]

Common Name

English

CHLORIDE ANION

Common Name

English

Chloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68243