U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Cl
Molecular Weight 35.4529
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of CHLORIDE ION

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

38361600000
PubMed

PubMed

TitleDatePubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.
1982 Oct
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
1985 Aug
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
1991 Sep
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.
1996 Feb
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].
2005 Jun
Pulmonary aspiration: new therapeutic approaches in the experimental model.
2005 Sep
Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem.
2005 Sep 14
Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats.
2006 Dec
Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.
2006 Feb
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
2006 Feb
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].
2006 Jun
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.
2006 Jun
[Effects of lateral position and independent lung ventilation on unilateral acute lung injury in dogs].
2006 May
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.
2006 Oct
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.
2007 Apr
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.
2007 Jul-Aug
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.
2007 Sep 1
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.
2008 Apr 23
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.
2008 Aug
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].
2008 Jun
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.
2008 Jun
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.
2008 Jun
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.
2008 Mar
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.
2008 May
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.
2008 Sep
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.
2009 Apr
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.
2009 Apr 1
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.
2009 Aug
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.
2009 Feb
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
2009 Jan
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
2009 Jul 15
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].
2009 Jun
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.
2009 Jun
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.
2009 Nov
Animal study for airway inflammation triggered by gastroesophageal reflux.
2009 Nov 20
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.
2009 Oct
Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.
2009 Sep
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
2010
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010 Aug
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
2010 Aug
NHE4 is critical for the renal handling of ammonia in rodents.
2010 Jun
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
2010 Nov
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
2010 Nov
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.
2010 Nov 29
Altered sensorimotor responses to esophageal acidification in older adults with GERD.
2010 Oct
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
2010 Sep
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.
2011 May
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.
2013 Feb
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.
2015 Jan 5
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:47:30 UTC 2021
Edited
by admin
on Sat Jun 26 01:47:30 UTC 2021
Record UNII
Q32ZN48698
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORIDE ION
Common Name English
PERCHLORIDE
Common Name English
CHLORIDE [VANDF]
Common Name English
CHLORIDE [WHO-DD]
Common Name English
CHLORIDE
VANDF   WHO-DD  
Systematic Name English
CHLORIDE ANION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68243
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LOINC 2075-0
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NCI_THESAURUS C597
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LOINC 51695-5
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LOINC 53640-9
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DSLD 37 (Number of products:1261)
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LOINC 2078-4
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CFR 21 CFR 862.1170
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Code System Code Type Description
EPA CompTox
16887-00-6
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PRIMARY
EVMPD
SUB32047
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PRIMARY
PUBCHEM
312
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PRIMARY
CAS
16887-00-6
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PRIMARY
DRUG BANK
DB14547
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PRIMARY
RXCUI
153974
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C1741
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
FDA UNII
Q32ZN48698
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
WIKIPEDIA
Chloride
Created by admin on Sat Jun 26 01:47:32 UTC 2021 , Edited by admin on Sat Jun 26 01:47:32 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
ASSAY (TITRATION)
USP
Related Record Type Details
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
TITRATION
USP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
Chlorides (2.4.4): maximum 100 ppm.
EP
PARENT -> IMPURITY
EP
Related Record Type Details
ACTIVE MOIETY