U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Cl
Molecular Weight 35.453
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of CHLORIDE ION

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

3.83616E10
PubMed

PubMed

TitleDatePubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.
1982 Oct
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
1985 Aug
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
1991 Sep
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.
1996 Feb
Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem.
2005 Sep 14
Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.
2006 Feb
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
2006 Feb
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.
2006 Jun
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.
2006 Nov
Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells.
2007 Feb
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.
2007 Jul-Aug
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.
2007 Oct
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.
2008 Apr 23
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.
2008 Aug
Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.
2008 Feb
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].
2008 Jun
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.
2008 Jun
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.
2008 Jun
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.
2008 May
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.
2009 Apr
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.
2009 Apr 1
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.
2009 Aug
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.
2009 Feb
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
2009 Jul 15
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].
2009 Jun
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.
2009 Jun
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.
2009 Mar
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
2009 May
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.
2009 Nov
Animal study for airway inflammation triggered by gastroesophageal reflux.
2009 Nov 20
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.
2009 Oct
Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.
2009 Sep
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
2010
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.
2010
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.
2010 Aug
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010 Aug
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
2010 Aug
NHE4 is critical for the renal handling of ammonia in rodents.
2010 Jun
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
2010 Nov
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
2010 Nov
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.
2010 Nov 29
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
2010 Oct
Altered sensorimotor responses to esophageal acidification in older adults with GERD.
2010 Oct
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
2010 Sep
The effect of tidal volume on systemic inflammation in Acid-induced lung injury.
2011
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells.
2011 Feb
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.
2011 May
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.
2013 Dec 15
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.
2013 Feb
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:26:54 UTC 2023
Edited
by admin
on Fri Dec 15 16:26:54 UTC 2023
Record UNII
Q32ZN48698
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORIDE ION
Common Name English
PERCHLORIDE
Common Name English
CHLORIDE [VANDF]
Common Name English
CHLORIDE
VANDF   WHO-DD  
Systematic Name English
CHLORIDE ANION
Common Name English
Chloride [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68243
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LOINC 2075-0
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NCI_THESAURUS C597
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DSLD 37 (Number of products:1261)
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CFR 21 CFR 862.1170
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Code System Code Type Description
EPA CompTox
DTXSID6043969
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
SMS_ID
100000124340
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PRIMARY
EVMPD
SUB32047
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
CHEBI
17996
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
PUBCHEM
312
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
CAS
16887-00-6
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PRIMARY
DRUG BANK
DB14547
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
RXCUI
153974
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PRIMARY RxNorm
NCI_THESAURUS
C1741
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
DAILYMED
Q32ZN48698
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
FDA UNII
Q32ZN48698
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
WIKIPEDIA
Chloride
Created by admin on Fri Dec 15 16:26:55 UTC 2023 , Edited by admin on Fri Dec 15 16:26:55 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
ASSAY (TITRATION)
USP
Related Record Type Details
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
TITRATION
USP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
EP
PARENT -> IMPURITY
Chlorides (2.4.4): maximum 100 ppm.
EP
PARENT -> IMPURITY
EP
Related Record Type Details
ACTIVE MOIETY