ADIMOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C25H29N3O3
Molecular Weight	419.5161
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(CCN1C(=O)NC2=C1C=CC=C2)NCC(O)COC3=CC=CC4=C3C=CC=C4

InChI

InChIKey=YWRIUGFSIQMHJK-UHFFFAOYSA-N

InChI=1S/C25H29N3O3/c1-25(2,14-15-28-22-12-6-5-11-21(22)27-24(28)30)26-16-19(29)17-31-23-13-7-9-18-8-3-4-10-20(18)23/h3-13,19,26,29H,14-17H2,1-2H3,(H,27,30)

HIDE SMILES / InChI

Molecular Formula	C25H29N3O3
Molecular Weight	419.5161
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2862877 | https://www.ncbi.nlm.nih.gov/pubmed/2859871 | https://www.ncbi.nlm.nih.gov/pubmed/2890141 | https://www.ncbi.nlm.nih.gov/pubmed/2885022

Adimolol is an antihypertensive agent with a potent antagonist of central beta-adrenoceptors and has a weaker alpha 1-adrenolytic action. The central alpha 2-antagonistic effect is either very weak or absent. The reduction in beta-adrenoceptor number following adimolol suggests that this prolonged effect may not be solely due to competitive antagonism but may additionally depend upon non-competitive antagonism at beta-adrenoceptors. Adimolol reduced supine, standing and exercise heart rates in a dose dependent manner.

Approval Year

Sample Use Guides

In Vivo Use Guide

Single dose - 25, 200, 400 or 800 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:28:32 GMT 2023` Edited by `admin` on `Sat Dec 16 17:28:32 GMT 2023`
Record UNII	B6CJY5K2ST
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADIMOLOL

Official Name

English

(±)-1-(3-((2-HYDROXY-3-(1-NAPHTHYLOXY)PROPYL)AMINO)-3-METHYLBUTYL)-2-BENZIMIDAZOLINONE

Systematic Name

English

adimolol [INN]

Common Name

English

MEN-935

Code

English

ADIMOLOL [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576