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Details

Stereochemistry RACEMIC
Molecular Formula C25H29N3O3
Molecular Weight 419.517
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ADIMOLOL

SMILES

CC(C)(CCn1c2ccccc2nc1O)NCC(COc3cccc4ccccc43)O

InChI

InChIKey=YWRIUGFSIQMHJK-UHFFFAOYSA-N
InChI=1S/C25H29N3O3/c1-25(2,14-15-28-22-12-6-5-11-21(22)27-24(28)30)26-16-19(29)17-31-23-13-7-9-18-8-3-4-10-20(18)23/h3-13,19,26,29H,14-17H2,1-2H3,(H,27,30)

HIDE SMILES / InChI

Molecular Formula C25H29N3O3
Molecular Weight 419.517
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Adimolol is an antihypertensive agent with a potent antagonist of central beta-adrenoceptors and has a weaker alpha 1-adrenolytic action. The central alpha 2-antagonistic effect is either very weak or absent. The reduction in beta-adrenoceptor number following adimolol suggests that this prolonged effect may not be solely due to competitive antagonism but may additionally depend upon non-competitive antagonism at beta-adrenoceptors. Adimolol reduced supine, standing and exercise heart rates in a dose dependent manner.

Approval Year

Sample Use Guides

Single dose - 25, 200, 400 or 800 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Jun 25 23:08:47 UTC 2021
Edited
by admin
on Fri Jun 25 23:08:47 UTC 2021
Record UNII
B6CJY5K2ST
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADIMOLOL
INN   MART.  
INN  
Official Name English
(+/-)-1-(3-((2-HYDROXY-3-(1-NAPHTHYLOXY)PROPYL)AMINO)-3-METHYLBUTYL)-2-BENZIMIDAZOLINONE
Systematic Name English
ADIMOLOL [INN]
Common Name English
MEN-935
Code English
ADIMOLOL [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29576
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
Code System Code Type Description
FDA UNII
B6CJY5K2ST
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
ChEMBL
CHEMBL1742448
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
PUBCHEM
71227
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
CAS
78459-19-5
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
NCI_THESAURUS
C73013
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
WIKIPEDIA
ADIMOLOL
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
EVMPD
SUB05270MIG
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
MESH
C045342
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
INN
5327
Created by admin on Fri Jun 25 23:08:47 UTC 2021 , Edited by admin on Fri Jun 25 23:08:47 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
TARGET -> INHIBITOR
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
may inhibit other alpha-1 receptors
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC