BETA-1 ADRENERGIC RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:42:29 GMT 2025` Edited by `admin` on `Tue Apr 01 16:42:29 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	4A4MK4KIB5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BETA-1 ADRENERGIC RECEPTOR

Common Name

English

ADRB1R

Preferred Name

English

Noradrenergic ?1 receptor

Common Name

English

ADRB1

Common Name

English

B1AR

Common Name

English

BETA-1

Common Name

English

beta1

Common Name

English

Code System Code Type Description

WIKIPEDIA

BETA-1_ADRENERGIC_RECEPTOR

Created by admin on Tue Apr 01 16:42:29 GMT 2025 , Edited by admin on Tue Apr 01 16:42:29 GMT 2025

PRIMARY

PHAROS

P08588

Created by admin on Tue Apr 01 16:42:29 GMT 2025 , Edited by admin on Tue Apr 01 16:42:29 GMT 2025

PRIMARY

FDA UNII

4A4MK4KIB5

Created by admin on Tue Apr 01 16:42:29 GMT 2025 , Edited by admin on Tue Apr 01 16:42:29 GMT 2025

PRIMARY

UNIPROT

P08588

Created by admin on Tue Apr 01 16:42:29 GMT 2025 , Edited by admin on Tue Apr 01 16:42:29 GMT 2025

PRIMARY

From	To
1_131	1_216
1_209	1_215

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_15

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					9Y8NXQ24VQ

PROPRANOLOL

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FORMOTEROL

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					0K47UL67F2

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					46OL1UC10R

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non-selective beta blocker

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DOBUTAMINE

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BEVANTOLOL

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INHIBITOR -> TARGET

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SOTALOL

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AGONIST -> TARGET

Interaction Type:

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Amount:


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Amount:


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Interaction Type:

SHORT-ACTING

Amount:


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ANTAGONIST->TARGET

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Levobunolol (LB) is the levo-rotatory isomer of bunolol, a potent, nonselective antagonist of beta-adrenergic receptors.


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Amount:


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Amount:


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Amount:


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INHIBITOR -> TARGET

Comments:

Chinese hamster ovary (CHO) cells stably expressing the three ?-adrenergic receptor subtypes at comparable levels.

Qualification:

Amount:


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INHIBITOR -> TARGET

Amount:


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AGONIST -> TARGET

Amount:


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Amount:


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INHIBITOR -> TARGET

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Amount:


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Qualification:

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_312] [1_412]				DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_428]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL