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Details

Stereochemistry RACEMIC
Molecular Formula C25H29N3O3.ClH.H2O
Molecular Weight 473.9932
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ADIMOLOL HYDROCHLORIDE MONOHYDRATE

SMILES

CC(C)(CCn1c2ccccc2nc1O)NCC(COc3cccc4ccccc43)O.Cl.O

InChI

InChIKey=ADETVRISJJRVMM-UHFFFAOYSA-N
InChI=1S/C25H29N3O3.ClH.H2O/c1-25(2,14-15-28-22-12-6-5-11-21(22)27-24(28)30)26-16-19(29)17-31-23-13-7-9-18-8-3-4-10-20(18)23;;/h3-13,19,26,29H,14-17H2,1-2H3,(H,27,30);1H;1H2

HIDE SMILES / InChI

Molecular Formula C25H29N3O3
Molecular Weight 419.517
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Adimolol is an antihypertensive agent with a potent antagonist of central beta-adrenoceptors and has a weaker alpha 1-adrenolytic action. The central alpha 2-antagonistic effect is either very weak or absent. The reduction in beta-adrenoceptor number following adimolol suggests that this prolonged effect may not be solely due to competitive antagonism but may additionally depend upon non-competitive antagonism at beta-adrenoceptors. Adimolol reduced supine, standing and exercise heart rates in a dose dependent manner.

Approval Year

Sample Use Guides

Single dose - 25, 200, 400 or 800 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 16:36:56 UTC 2021
Edited
by admin
on Sat Jun 26 16:36:56 UTC 2021
Record UNII
76X4B195Z3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADIMOLOL HYDROCHLORIDE MONOHYDRATE
Common Name English
2H-BENZIMIDAZOL-2-ONE, 1,3-DIHYDRO-1-(3-((2-HYDROXY-3-(1-NAPHTHALENYLOXY)PROPYL)AMINO)-3-METHYLBUTYL)-, HYDROCHLORIDE, HYDRATE (1:1:1)
Systematic Name English
2H-BENZIMIDAZOL-2-ONE, 1,3-DIHYDRO-1-(3-((2-HYDROXY-3-(1-NAPHTHALENYLOXY)PROPYL)AMINO)-3-METHYLBUTYL)-, MONOHYDROCHLORIDE, MONOHYDRATE, (+/-)-
Systematic Name English
MEN-935 HYDROCHLORIDE MONOHYDRATE
Code English
Code System Code Type Description
PUBCHEM
156363
Created by admin on Sat Jun 26 16:36:56 UTC 2021 , Edited by admin on Sat Jun 26 16:36:56 UTC 2021
PRIMARY
FDA UNII
76X4B195Z3
Created by admin on Sat Jun 26 16:36:56 UTC 2021 , Edited by admin on Sat Jun 26 16:36:56 UTC 2021
PRIMARY
CAS
83487-83-6
Created by admin on Sat Jun 26 16:36:56 UTC 2021 , Edited by admin on Sat Jun 26 16:36:56 UTC 2021
PRIMARY
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