MAGNESIUM FUMARATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H2O4.Mg
Molecular Weight	138.3613
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Mg++].[O-]C(=O)\C=C\C([O-])=O

InChI

InChIKey=QUIOHQITLKCGNW-TYYBGVCCSA-L

InChI=1S/C4H4O4.Mg/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;

HIDE SMILES / InChI

Molecular Formula	Mg
Molecular Weight	24.305
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H2O4
Molecular Weight	114.0563
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/351265https://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9https://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640https://www.drugs.com/dosage/magnesium-lactate.htmlhttps://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1https://www.drugs.com/ppa/magnesium-chloride.htmldoi: 10.1081/SCC-120022479https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttp://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfDOI: 10.2903/j.efsa.2008.883http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243http://www.sciencedirect.com/science/article/pii/004484868990080Xhttp://www.db-pharma.com/anglais/49.pdf
Curator's Comment: description was created based on several sources, including: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride | DOI: 10.1002/0471238961.0218151310010311.a02 | http://mon-naturopathe.com/blog/techniques-naturopathiques/chlorure-de-magnesium-et-delbiase

Magnesium bromide is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Also it is recommended for magnesium deficiency. In case of associated calcium deficiency, treat magnesium deficiency before calcium deficiency. Magnesium bromide is used in medicine as a mild sedative for treatment of nervous disorders.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
action potential 66 Target ID: GO:0001508 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12225296	Inhibitor 8146
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/26812001	Modulator 817
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webmd.com/drugs/2/drug-10702-5106/magnesium-dr/details	Modulator 817
oxalate metabolic process 66 Target ID: GO:0033609 Sources: https://www.medicinep.com/epimag-for-cases-of-oxaluria-and-mild-laxative-to-relieve-constipation-2918.html	Modulator 817
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Modulator 817
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc \| https://www.drugs.com/mtm/magnesium-lactate.html	Interacts 314
Protein S100-A8 66 Target ID: P05109 Gene ID: 6279.0 Gene Symbol: S100A8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8061680	Binding Agent 1037

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2554
Unknown 2554
Bone disease 70 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27792982	Primary	Basic research	Unknown Approved Use Unknown
Bacterial infections 231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27995243	Primary	Preclinical	Unknown Approved Use Unknown
Bronchial spasm 78 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20647692	Primary	Preclinical	Unknown Approved Use Unknown
Unknown 2554
Unknown 2554
Unknown 2554
Preeclampsia 84 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Preventing	Approved 8307	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Eclampsia 69 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Primary	Approved 8307	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Preparation for colonoscopy 66 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204553s001lbl.pdf	Diagnostic	Approved 8307	ColPrep Kit Approved Use INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults Launch Date 1.48279683E12
Atrial fibrillation 131 Sources: https://clinicaltrials.gov/ct2/show/NCT00965874	Primary	Phase III 651	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 7.9038723E11
Unknown 2554
Magnesium deficiency 67 Sources: https://www.blackmores.com.au/products/magmin	Curative	Approved 8307	MagMin Approved Use Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Unknown 2554
Magnesium deficiency 67 Sources: http://www.db-pharma.com/anglais/49.pdf	Curative	Not Provided 505	DELBIASE Approved Use Unknown
Eclampsia 69 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 505	DELBIASE Approved Use Unknown
Convulsions 72 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 505	DELBIASE Approved Use Unknown
Magnesium deficiency 67 Sources: http://www.meritpharm.com/wp-content/uploads/2014/03/Chloromag.Magnesium-Chloride.MSDS_.pdf	Curative	Approved 8307	Magnesium Chloride Approved Use Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Fibromyalgia 89 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26343101	Palliative	Phase II 1133	Magnesium Chloride Approved Use Unknown
Stroke 143 Sources: https://clinicaltrials.gov/ct2/show/NCT00933868	Palliative	Phase III 651	Magnesium Chloride Approved Use Unknown
Oxaluria 66 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8307	EPIMAG Approved Use Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Constipation 112 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8307	EPIMAG Approved Use Used to relief of occasional constipation (irregularity).
Magnesium deficiency 67 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Curative	Approved 8307	Magnesium Citrate Approved Use Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Unknown 2554
Magnesium deficiency 67 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc https://www.drugs.com/mtm/magnesium-lactate.html	Curative	Approved 8307	Unknown Approved Use Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

PubMed

Title	Date	PubMed
[Magnesium--an alternative in treatment resistant tachyarrhythmias].	1977 May 30	867390
Struvite stones.	1978 May	351265
Symptomatic hypercalcaemia precipitated by magnesium therapy.	1985 Jan	3991404
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.	1986 Apr	3728201
Effects of the intravenous administration of magnesium sulfate on corrected serum calcium level and nephrogenous cyclic AMP excretion in normal human subjects.	1986 Nov	3028586
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.	1986 Sep	3527812
Fluorimetry of selenium in body fluids after digestion with nitric acid, magnesium nitrate hexahydrate, and hydrochloric acid.	1988 Sep	2843308
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.	1989 Jun 15	2542339
Persistent paralysis in critically ill patients after long-term administration of vecuronium.	1992 Aug 20	1353252
['Cardiac ballet' with and without amiodarone].	1993 Jan 13	8421775
Magnesium supplementation in patients with congestive heart failure.	1997 Feb	9013430
Aluminum is a weak agonist for the calcium-sensing receptor.	1999 May	10231437
Effect of chronic magnesium supplementation on magnesium distribution in healthy volunteers evaluated by 31P-NMRS and ion selective electrodes.	1999 Nov	10594466
Influence of maternal magnesium sulphate and ritodrine treatment on the neonate: a study with six-month follow-up.	1999 Oct	10565464
Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery.	1999 Oct	10552215
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.	2000 Aug	10913914
Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.	2000 Nov	11101042
Complement activation in factor D-deficient mice.	2001 Dec 4	11724962
[QT prolongation and torsade de pointes tachycardia during therapy with maprotiline. Differential diagnostic and therapeutic aspects].	2001 Dec 7	11740632
Evidence supporting a role for KCl cotransporter in the thick ascending limb of Henle's loop.	2001 Nov	11703599
Contraindication of magnesium sulfate in a pregnancy complicated with late-onset diabetes mellitus and sensory deafness due to mitochondrial myopathy.	2001 Oct	11730501
Magnesium bromide mediated highly diastereoselective heterogeneous hydrogenation of olefins.	2002 Apr 18	11950359
Infantile renal dysfunction associated with intrauterine exposure to ritodrine and magnesium sulfate.	2002 Jun	12053081
Enhancement of endotoxin-induced vascular hyporeactivity to phenylephrine in the thoracic aortas of Mg-deficient rats ex vivo.	2003 Oct 10	13679239
Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis.	2004 Aug	15039145
Use of ibutilide in cardioversion of patients with atrial fibrillation or atrial flutter treated with class IC agents.	2004 Aug 18	15312873
A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.	2004 May	15068510
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.	2005	16325539
Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two cases.	2005 Jan	15625263
Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.	2005 Oct	16192781
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.	2006 Feb	16269826
Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism.	2006 Mar	16846101
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007 Sep	17916923
Magnesium ions and opioid agonist activity in streptozotocin-induced hyperalgesia.	2008	18701828
High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain.	2009	19204407
Cocaine use disorders and serum magnesium profile.	2009	19439996
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.	2009 Jun 25	19459639
Increased expression of glucose transporter 3 in gerbil brains following magnesium sulfate treatment and focal cerebral ischemic injury.	2010 Jun	20517896
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.	2010 Oct 1	20655937
Mechanically enforced bond dissociation reports synergistic influence of Mn2+ and Mg2+ on the interaction between integrin α7β1 and invasin.	2011 Jul-Aug	21584882
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.	2011 May 30	21276780
Catalytic contribution of threonine 244 in human ALDH2.	2013 Feb 25	23295226
[The effectiveness of certain magnesium salts in nephrolithiasis caused by the use of sodium oxalate and celecoxib].	2013 Jan-Feb	23662491
Effects of three kinds of organic acids on phosphorus recovery by magnesium ammonium phosphate (MAP) crystallization from synthetic swine wastewater.	2014 Apr	24296029
A comparison of oral sulfate solution with sodium picosulfate: magnesium citrate in split doses as bowel preparation for colonoscopy.	2014 Dec	25028274
Precipitation of amorphous magnesium ammonium phosphate: is it a precursor for staghorn stones?	2014 Jun	24643665
Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate.	2015 Feb	25410648
Single-day sodium picosulfate and magnesium citrate versus split-dose polyethylene glycol for bowel cleansing prior to colonoscopy: A prospective randomized endoscopist-blinded trial.	2015 Nov	25968966
MgF2-coated porous magnesium/alumina scaffolds with improved strength, corrosion resistance, and biological performance for biomedical applications.	2016 May	26952467
A Soft Grip: Magnesium Complexes with a Phosphine-Modified Phosphonium Diylidic Lewis Base.	2016 Nov 21	27775201

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 16 17:55:28 UTC 2022` Edited by `admin` on `Fri Dec 16 17:55:28 UTC 2022`
Record UNII	A3NK08CQA4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAGNESIUM FUMARATE

Systematic Name

English

Magnesium fumarate [WHO-DD]

Common Name

English

2-BUTENEDIOIC ACID (E)-, MAGNESIUM SALT

Common Name

English

FUMARIC ACID, MAGNESIUM SALT

Common Name

English

2-BUTENEDIOIC ACID (E)-, MAGNESIUM SALT (1:1)

Common Name

English

FUMARIC ACID, MAGNESIUM SALT (1:1)

Common Name

English

2-BUTENEDIOIC ACID (2E)-, MAGNESIUM SALT (1:1)

Common Name

English

MAGNESIUM 2-BUTENEDIOATE, (E)-

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 172.350