DescriptionSources: http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.alfa.com/en/catalog/032808/https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367https://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://google.com/patents/CN104529454A?Curator's Comment: description was created based on several sources, including
http://www.sciencedirect.com/science/article/pii/S002202480400507X | https://www.ncbi.nlm.nih.gov/pubmed/7284642
Sources: http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.alfa.com/en/catalog/032808/https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367https://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://google.com/patents/CN104529454A?
Curator's Comment: description was created based on several sources, including
http://www.sciencedirect.com/science/article/pii/S002202480400507X | https://www.ncbi.nlm.nih.gov/pubmed/7284642
Manganese Difluoride is a light pink crystalline solid composed of manganese and fluoride with the formula MnF2. Manganese Difluoride is made by treating manganese and diverse compounds of manganese(II) in hydrofluoric acid. Manganese Difluoride is used in the manufacture of special kinds of glass and lasers.
Originator
Sources: https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19610920&CC=GB&NR=877677A&KC=Ahttps://www.americanelements.com/manganese-ii-iodide-7790-33-2http://www.newworldencyclopedia.org/entry/Manganese
Curator's Comment: Manganese was first discovered by Torbern Olof Bergman in 1770 and first isolated by Johann Gottlieb Gahn in 1774.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1075097 |
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Target ID: CHEMBL1795148 |
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Target ID: CHEMBL4612 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseManganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese. |
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| Primary | Unknown Approved UseManganese is used for weak bones (osteoporosis). |
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| Palliative | Unknown Approved UseEarly research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension. |
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| Curative | MANGANESE SULFATE Approved UseManganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms. |
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| Primary | MANGANESE SULFATE Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cytochrome oxidase determination using a manganese citrate complex. | 1970 |
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| Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants. | 1985 Feb |
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| Dietary calcium and manganese effects on menstrual cycle symptoms. | 1993 May |
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| Differential ability of transition metals to induce pulmonary inflammation. | 2001 Nov 15 |
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| Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. | 2007 Jun |
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| Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries. | 2016 Oct |
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| Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence. | 2017 Apr 7 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
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Mixture
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21 CFR 184.1452
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