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Details

Stereochemistry ACHIRAL
Molecular Formula C5H6O4
Molecular Weight 130.0987
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of MONOMETHYL FUMARATE

SMILES

COC(=O)\C=C\C(O)=O

InChI

InChIKey=NKHAVTQWNUWKEO-NSCUHMNNSA-N
InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+

HIDE SMILES / InChI

Molecular Formula C5H6O4
Molecular Weight 130.0987
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Maleic acid (cis-butenedioic acid) is the cis-isomer of fumaric acid (trans-butenedioic acid). In industry, maleic acid is derived by hydrolysis of maleic anhydride, the latter being produced by oxidation of benzene or butane. Maleic acid is an industrial raw material for the production of glyoxylic acid by ozonolysis. Maleic acid is also used as an adhesion promoter for different substrates, such as nylon and zinc coated metals e.g galvanized steel, in methyl methacrylate based adhesives. The major industrial use of maleic acid is its conversion to fumaric acid. This conversion, an isomerization, is catalysed by a variety of reagents, such as mineral acids and thiourea. According to the California Environmental Protection Agency, the statewide emission rate of maleic anhydride from industrial facilities is estimated at 3340 kg/year. Maleic acid is also used as an adhesive in dentistry, as well as a fragrance ingredient and pH adjuster in many cosmetic and pharmaceutical products at low concentrations (0.004%). The large difference in water solubility makes fumaric acid purification easy. Some bacteria produce the enzyme maleate isomerase, which is used by bacteria in nicotinate metabolism. Maleic acid may be used to form acid addition salts with drugs to make them more stable. Many drugs that contain amines are provided as the maleate acid salt, e.g. carfenazine, chlorpheniramine, pyrilamine, methylergonovine, and thiethylperazine.

CNS Activity

Curator's Comment: Dimethyl fumarate is probably too hydrophilic to cross the blood-CNS barrier. DMF stabilized the BBB by preventing disruption of interendothelial tight junctions and gap formation, and decreased matrix metalloproteinase activity in brain tissue.

Originator

Curator's Comment: In September 2003, Biogen (now Biogen Idec) licensed exclusive worldwide rights (excluding Germany) from Fumapharm to develop and market BG 12.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q96KS0
Gene ID: 112398.0
Gene Symbol: EGLN2
Target Organism: Homo sapiens (Human)
120.0 µM [IC50]
Target ID: Q9H6Z9
Gene ID: 112399.0
Gene Symbol: EGLN3
Target Organism: Homo sapiens (Human)
60.0 µM [IC50]
Target ID: Q9GZT9
Gene ID: 54583.0
Gene Symbol: EGLN1
Target Organism: Homo sapiens (Human)
80.0 µM [IC50]
Target ID: Glutathione S-transferase
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Secondary
TECFIDERA

Approved Use

Indicated for the treatment of patients with relapsing forms of multiple sclerosis

Launch Date

1.36434234E12
Palliative
Unknown

Approved Use

Unknown
Primary
TECFIDERA

Approved Use

TECFIDERA, dimethyl fumarate undergoes rapid presystemic hydrolysis by esterases and is converted to its active metabolite, monomethyl fumarate (MMF). TECFIDERA is indicated for the treatment of patients with relapsing forms of multiple sclerosis.

Launch Date

1.36425597E12
Preventing
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.87 mg/L
240 mg 2 times / day multiple, oral
dose: 240 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
MONOMETHYL FUMARATE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
8.21 mg × h/L
240 mg 2 times / day multiple, oral
dose: 240 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
MONOMETHYL FUMARATE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1 h
240 mg 2 times / day multiple, oral
dose: 240 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
MONOMETHYL FUMARATE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
64%
240 mg 2 times / day multiple, oral
dose: 240 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
MONOMETHYL FUMARATE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
Doses

Doses

DosePopulationAdverse events​
190 mg 2 times / day multiple, oral
Highest studied dose
Dose: 190 mg, 2 times / day
Route: oral
Route: multiple
Dose: 190 mg, 2 times / day
Sources: Page: 6.1
unhealthy, adult
n = 769
Health Status: unhealthy
Condition: multiple sclerosis
Age Group: adult
Sex: unknown
Population Size: 769
Sources: Page: 6.1
190 mg 2 times / day multiple, oral
Highest studied dose
Dose: 190 mg, 2 times / day
Route: oral
Route: multiple
Dose: 190 mg, 2 times / day
Sources:
unhealthy, mean 37 years
n = 105
Health Status: unhealthy
Condition: multiple sclerosis
Age Group: mean 37 years
Sex: M+F
Population Size: 105
Sources:
Other AEs: Gastrointestinal disturbance...
Other AEs:
Gastrointestinal disturbance (53%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Gastrointestinal disturbance 53%
190 mg 2 times / day multiple, oral
Highest studied dose
Dose: 190 mg, 2 times / day
Route: oral
Route: multiple
Dose: 190 mg, 2 times / day
Sources:
unhealthy, mean 37 years
n = 105
Health Status: unhealthy
Condition: multiple sclerosis
Age Group: mean 37 years
Sex: M+F
Population Size: 105
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer





Drug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
no
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Antifungal properties of 2-bromo-3-fluorosuccinic acid esters and related compounds.
1977 Apr
The influence of long-term treatment with timolol on human tear lysozyme albumin content.
1982
Microperfusion study of proximal tubule bicarbonate transport in maleic acid-induced renal tubular acidosis.
1986 Mar
Do contrast media aggravate Fanconi's syndrome in rats? A comparison of diatrizoate, iohexol, and ioxilan.
1988 Sep
Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.
1991 Jan 2
Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.
1994 Jun
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
1996 Dec
The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by (1)H nuclear magnetic resonance spectroscopy.
2002 May 15
Dynamic alterations of fibronectin layers on copolymer substrates with graded physicochemical characteristics.
2004 Mar 30
Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats.
2005 Aug 15
Protein adsorption from flowing solutions on pure and maleic acid copolymer modified glass particles.
2006 Aug 1
Probing carboxylate Gibbs transfer energies via liquid|liquid transfer at triple phase boundary electrodes: ion-transfer voltammetry versus COSMO-RS predictions.
2008 Jul 14
Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
2010 May
Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.
2013 Oct
Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I.
2014 Nov
Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model.
2017 Dec
Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells.
2019 Jan
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: In group of dogs experimental Fanconi syndrome (generalized proximal tubular dysfunction) was induced with maleic acid (25 mg/kg iv, pH 7.3). https://www.ncbi.nlm.nih.gov/pubmed/1858895
in cow: The aim of this study was to determine the influence of fumaric acid (FA) on ruminal fermentation and its effects on the acid-base balance of seven ruminally and duodenally fistulated multiparous German Holstein cows. The experiment was conducted in a change-over design with three periods in which the animals were randomly arranged in one of three treatments: Control (C; without FA), 300 or 600 g FA per day. The diets consisted of 7.4 kg DM grass silage, 4.2 kg concentrate mixture and 0, 300 or 600 g FA or wheat starch as isocaloric compensation per day and cow. FA supplementation decreased the rumen pH, acetic acid and butyric acid and increased propionic acid in rumen fluid. The results of the single-strand conformation polymorphism analysis (SSCP) did not show an influence of FA on the microbial population in the rumen
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Maleic acid-induced inhibition of sugar and amino acid transport in the rat renal tubule was studied.
It was evaluated the effects of fumaric acid (FA) on tyrosinase activity and structure via enzyme kinetics and computational simulations. FA was found to be a reversible inhibitor of tyrosinase and its induced mechanism was the parabolic non-competitive inhibition type with IC50=13.7±0.25mM and Kislope=12.64±0.75mM. Kinetic measurements and spectrofluorimetry studies showed that FA induced regional changes in the active site of tyrosinase. One possible binding site for FA was identified under the condition without L-DOPA. The computational docking simulations further revealed that FA can interact with HIS263 and HIS85 at the active site. Furthermore, four important hydrogen bonds were found to be involved with the docking of FA on tyrosinase. By inhibiting tyrosinase and its central role in pigment production, FA is a potential natural antipigmentation agent.
Substance Class Chemical
Created
by admin
on Thu Jul 06 01:21:58 UTC 2023
Edited
by admin
on Thu Jul 06 01:21:58 UTC 2023
Record UNII
45IUB1PX8R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOMETHYL FUMARATE
USAN   INN  
Official Name English
METHYL HYDROGEN FUMARATE
Systematic Name English
MONOMETHYL FUMARATE [USAN]
Common Name English
NSC-523835
Code English
MMF
Common Name English
FUMARIC ACID MONOMETHYL ESTER [MI]
Common Name English
FUMARIC ACID MONOMETHYL ESTER
MI  
Systematic Name English
Monomethyl fumarate [WHO-DD]
Common Name English
MONOMETHYL FUMARATE [ORANGE BOOK]
Common Name English
monomethyl fumarate [INN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 724619
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
Code System Code Type Description
WIKIPEDIA
Monomethyl fumarate
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
PUBCHEM
5369209
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
RXCUI
1546433
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
220-412-6
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
NCI_THESAURUS
C166722
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
CAS
2756-87-8
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
INN
11163
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
SMS_ID
100000170158
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
DRUG BANK
DB14219
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
CHEBI
167450
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
EPA CompTox
DTXSID801016498
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
EVMPD
SUB184027
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
RS_ITEM_NUM
1210229
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
USAN
FG-183
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
DAILYMED
45IUB1PX8R
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
FDA UNII
45IUB1PX8R
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
NSC
523835
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY
MERCK INDEX
M5586
Created by admin on Thu Jul 06 01:21:59 UTC 2023 , Edited by admin on Thu Jul 06 01:21:59 UTC 2023
PRIMARY Merck Index
Related Record Type Details
BINDER->LIGAND
BINDING
TARGET -> ACTIVATOR
Related Record Type Details
PRODRUG -> METABOLITE ACTIVE
METABOLITE -> PARENT
MAJOR
EXHALATION
PARENT -> METABOLITE ACTIVE
PRODRUG -> METABOLITE ACTIVE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC