U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 01:47:17 GMT 2025
Edited
by admin
on Wed Apr 02 01:47:17 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
P93F057EMS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HEBP-1
Preferred Name English
NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2
Common Name English
HEBP1
Common Name English
NFE2L2
Common Name English
Nrf2
Common Name English
NF-E2-RELATED FACTOR 2
Common Name English
NFE2-RELATED FACTOR 2
Common Name English
NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 (NRF2)
Common Name English
NUCLEAR FACTOR, ERYTHROID DERIVED 2, LIKE 2
Common Name English
Code System Code Type Description
UNIPROT
Q16236
Created by admin on Wed Apr 02 01:47:17 GMT 2025 , Edited by admin on Wed Apr 02 01:47:17 GMT 2025
PRIMARY
FDA UNII
P93F057EMS
Created by admin on Wed Apr 02 01:47:17 GMT 2025 , Edited by admin on Wed Apr 02 01:47:17 GMT 2025
PRIMARY
Related Record Type Details
INDUCER -> TARGET
ACTIVATOR -> TARGET
Bardoxolone methyl covalently binds to the reactive cysteine residue(s) of Keap1, releasing Nrf2 from the proteasome pathway into the nucleus.
ACTIVATOR -> TARGET
ACTIVATOR -> TARGET
Reacts with reactive cysteine residues through covalent, resulting in the conformational changes of Keap1 and the release of Nrf2 from Keap1.
ACTIVATOR -> TARGET
Baicalein exerts its effects by inactivating Keap1 through interaction with the cysteine thiol residues of Keap1, subsequently inducing Nrf2 nuclear translocation.
ACTIVATOR -> TARGET
ACTIVATOR -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
ACTIVATOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL