U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CO2
Molecular Weight 44.0095
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARBON DIOXIDE

SMILES

C(=O)=O

InChI

InChIKey=CURLTUGMZLYLDI-UHFFFAOYSA-N
InChI=1S/CO2/c2-1-3

HIDE SMILES / InChI

Molecular Formula CO2
Molecular Weight 44.0095
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Carbon dioxide is a colorless gas occurring naturally in Earth's atmosphere. Carbon dioxide is a primary carbon source for life on Earth. It is produced by all aerobic organisms during metabolism of carbohydrates and lipids. Carbon dioxide is used in food industry as an acidity regulator and for production of carbonated soft drinks and soda water. In medicine, carbon dioxide is commonly used as an insufflation gas for minimally invasive surgery (laparoscopy, endoscopy, and arthroscopy) to enlarge and stabilize body cavities to provide better visibility of the surgical area. A mixture of carbon dioxide and oxygen is used for stimulation of breathing after apnea, in anesthetic procedures to increase the depth of respiration, to facilitate blind intubations in anesthetic practice.

CNS Activity

Curator's Comment:: Carbon dioxide is naturally produced in all tissues.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Carbon dioxide is used to stimulate respiration after a period of apnoea
Primary
Unknown

Approved Use

Carbon dioxide is used in chronic respiratory obstruction after it has been relieved
Palliative
Unknown

Approved Use

Carbon dioxide is used to increase cerebral blood flow in arteriosclerotic patients undergoing surgery
PubMed

PubMed

TitleDatePubMed
Oxidative degradation of phenanthrene by the ligninolytic fungus Phanerochaete chrysosporium.
1992 Jun
Prevention of caries by pulsed CO2 laser pre-treatment of enamel: an in-vitro study.
2001 Dec
An indirect ELISA for detection of Encephalitozoon cuniculi infection in farmed blue foxes (Alopex lagopus).
2002
Observations on the early results of treatment of recurrent respiratory papillomatosis using cidofovir.
2002 Dec
Spontaneous disappearance of refractory viral warts at distant sites following carbon-dioxide laser treatment.
2002 Dec
Induction of carbofuran oxidation to 4-hydroxycarbofuran by Pseudomonas sp. 50432.
2002 Sep 10
[Comparative estimation of effectiveness of nonsteroidal anti-inflammatory drugs used for postoperative pain management].
2003
[Effectiveness of ketonal and diclofenac in spondylarthrosis complicated with spinal pain].
2003
Acoustic attenuation in gas mixtures with nitrogen: experimental data and calculations.
2003 Apr
Mechanism of action of the diazabicyclononanone-type kappa-agonists.
2003 Apr 10
Mutation induced modulation of hydrogen bonding to P700 studied using FTIR difference spectroscopy.
2003 Aug 26
[Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term].
2003 Dec 7
Supercritical fluid processing of proteins: lysozyme precipitation from aqueous solution.
2003 Feb
Occult supraglottic lymphatic malformation presenting as obstructive sleep apnea.
2003 Mar
Can preconditioning reduce laparoscopy-induced tissue injury?
2003 May
High-sensitivity photoacoustic leak testing.
2003 Oct
Carbon-dioxide laser-assisted tonsil ablation for adults with chronic tonsillitis: a 6-month follow-up study.
2003 Sep
Energy cost and cardiorespiratory changes during the practice of Surya Namaskar.
2004 Apr
Anesthesiological hazards during laparoscopic transhiatal esophageal resection: a case control study of the laparoscopic-assisted vs the conventional approach.
2004 Aug
Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma.
2004 Dec
Tretinoin treatment before carbon-dioxide laser resurfacing: a clinical and biochemical analysis.
2004 Dec
Dynamic co-evolution of peptides and chemical energetics, a gateway to the emergence of homochirality and the catalytic activity of peptides.
2004 Feb
FTIR difference spectroscopy in combination with isotope labeling for identification of the carbonyl modes of P700 and P700+ in photosystem I.
2004 Feb
CO2, not HCO3-, facilitates oxidations by Cu,Zn superoxide dismutase plus H2O2.
2004 Jan 20
Supercritical carbon dioxide extraction of selected medicinal plants--effects of high pressure and added ethanol on yield of extracted substances.
2004 Jan-Feb
Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: analysis of 120 cases.
2004 Jul
Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin.
2004 Jul-Aug
Direct determination of carbon dioxide in aqueous solution using mid-infrared quantum cascade lasers.
2004 Jun
Use of CO2/O2 anesthesia in the collection of samples for serum corticosterone analysis from Fischer 344 rats.
2004 Mar
Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway.
2004 May
Meerwein-Ponndorf-Verley alkynylation of aldehydes: essential modification of aluminium alkoxides for rate acceleration and asymmetric synthesis.
2004 Nov 21
Metabolism of 2-mercaptobenzothiazole by Rhodococcus rhodochrous.
2004 Oct
Photochemical preparation of highly functionalized 1-indanones.
2004 Oct 29
Difference between diabetic and nondiabetic smokers in the pituitary response to physical exercise.
2004 Sep
Retention characteristics of porous graphitic carbon in subcritical fluid chromatography with carbon dioxide-methanol mobile phases.
2004 Sep 3
Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model.
2005
Effects of the cortisol synthesis inhibitor metyrapone on the response to carbon dioxide challenge in panic disorder.
2005
Coupling aggressive mass removal with microbial reductive dechlorination for remediation of DNAPL source zones: a review and assessment.
2005 Apr
Isolation and characterization of a rhodococcus species strain able to grow on ortho- and para-xylene.
2005 Aug
Metabolism of the aliphatic nitramine 4-nitro-2,4-diazabutanal by Methylobacterium sp. strain JS178.
2005 Aug
Laryngeal amyloidosis.
2005 Feb
[Development of gastrotonometry and the future of its use in the monitoring of critically ill patients].
2005 Jan 23
Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor.
2005 Jul
Strong effects of an individual water molecule on the rate of light-driven charge separation in the Rhodobacter sphaeroides reaction center.
2005 Jul 22
Physico-chemical characteristics of Anopheles culicifacies and Anopheles varuna breeding water in a dry zone stream in Sri Lanka.
2005 Jun
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
2005 Sep
Differentiation of human bone marrow stem cells into cells with a neural phenotype: diverse effects of two specific treatments.
2006 Feb 16
Ultrafast transient absorption studies on photosystem I reaction centers from Chlamydomonas reinhardtii. 2: mutations near the P700 reaction center chlorophylls provide new insight into the nature of the primary electron donor.
2006 Jan 15
Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice.
2006 Mar
Characterisation of stationary phases in subcritical fluid chromatography with the solvation parameter model. III. Polar stationary phases.
2006 Mar 31
Patents

Sample Use Guides

Carbon dioxide is usually administered through the lungs by inhalation. The major exceptions are when a metered supply is fed into the oxygenator of an extracorporeal circulation of a cardiopulmonary bypass system, and when the gas is used for laparoscopic surgery. As an additive to beverages, carbon dioxide is consumed orally.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:53:08 UTC 2021
Edited
by admin
on Fri Jun 25 20:53:08 UTC 2021
Record UNII
142M471B3J
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
CARBON DIOXIDE
EP   FCC   HSDB   II   INCI   MART.   MI   USP   VANDF   WHO-DD  
INCI  
Official Name English
CARBON DIOXIDE [EP]
Common Name English
CARBON DIOXIDE [GREEN BOOK]
Common Name English
CARBON DIOXIDE [INCI]
Common Name English
INS NO.290
Code English
CARBON DIOXIDE [HSDB]
Common Name English
E-290
Code English
CARBON DIOXIDE [WHO-DD]
Common Name English
DRY ICE (SOLID FORM)
Common Name English
CARBON DIOXIDE [VANDF]
Common Name English
INS-290
Code English
CARBON DIOXIDE [II]
Common Name English
CO2
Common Name English
CARBON DIOXIDE [USP MONOGRAPH]
Common Name English
CARBON DIOXIDE [EP MONOGRAPH]
Common Name English
CARBON DIOXIDE [MI]
Common Name English
CARBON DIOXIDE [FCC]
Common Name English
CARBONIC ACID ANHYDRIDE
Systematic Name English
CARBON DIOXIDE [MART.]
Common Name English
Classification Tree Code System Code
LOINC 16551-4
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LOINC 28644-3
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NDF-RT N0000180185
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LOINC 14640-7
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NDF-RT N0000010258
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LOINC 2021-4
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LOINC 2020-6
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LOINC 32306-3
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JECFA EVALUATION INS-290
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WHO-ATC A06AX02
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LOINC 19212-0
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CFR 21 CFR 862.1160
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LOINC 39466-8
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CODEX ALIMENTARIUS (GSFA) INS-290
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LOINC 28645-0
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LOINC 2022-2
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EPA PESTICIDE CODE 16601
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LOINC 2027-1
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LOINC 38253-1
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WHO-VATC QA06AX02
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LOINC 34728-6
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LOINC 14040-0
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LOINC 57922-7
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FDA ORPHAN DRUG 465114
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LOINC 57923-5
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LOINC 2026-3
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LOINC 20565-8
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DSLD 3848 (Number of products:1)
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LOINC 53458-6
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LOINC 2019-8
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LOINC 19223-7
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CFR 21 CFR 184.1240
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LOINC 2023-0
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WHO-VATC QV03AN02
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LOINC 11211-0
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LOINC 14003-8
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WHO-ATC V03AN02
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Code System Code Type Description
DRUG CENTRAL
4256
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
FDA UNII
142M471B3J
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
DRUG BANK
DB09157
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
JECFA MONOGRAPH
INS-290
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
CAS
124-38-9
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
EPA CompTox
124-38-9
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
MERCK INDEX
M3079
Created by admin on Fri Jun 25 20:53:09 UTC 2021 , Edited by admin on Fri Jun 25 20:53:09 UTC 2021
PRIMARY Merck Index
HSDB
516
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
ChEMBL
CHEMBL1231871
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
WIKIPEDIA
CARBON DIOXIDE
Created by admin on Fri Jun 25 20:53:09 UTC 2021 , Edited by admin on Fri Jun 25 20:53:09 UTC 2021
PRIMARY
PUBCHEM
280
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PRIMARY
MESH
D002245
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PRIMARY
NCI_THESAURUS
C65288
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PRIMARY
RXCUI
2034
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PRIMARY RxNorm
EVMPD
SUB13243MIG
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PRIMARY
ECHA (EC/EINECS)
204-696-9
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
CARBON DIOXIDE (% Vol.) Non-filtered cigarette(85 mm) Univ Kentucky- 9.4 Filtered cigarette(85 mm) New Yorl City- 9.6 Little cigars A(85 mm) Boston-8.5 Little cigars B (85 mm),New York City-13.2 Small cigars C(95 mm),New York City-12.7
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
PARENT -> METABOLITE INACTIVE
Unit: percent of total dose excreted (into Expired Air; 39.7% to 58.6%)
IN-VIVO
PARENT -> METABOLITE
MAJOR
EXHALATION
Related Record Type Details
ACTIVE MOIETY