U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C9H13NO2
Molecular Weight 167.205
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENYLEPHRINE

SMILES

CNC[C@H](O)C1=CC(O)=CC=C1

InChI

InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N
InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula C9H13NO2
Molecular Weight 167.205
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204300lbl.pdf and https://www.drugs.com/pro/phenylephrine-and-chlorpheniramine-tablets.html

Phenylephrine is a powerful vasoconstrictor. It is used as a nasal decongestant and cardiotonic agent. Phenylephrine is a postsynaptic α1-receptor agonist with little effect on β-receptors of the heart. Parenteral administration of phenylephrine causes a rise in systolic and diastolic pressures, a slight decrease in cardiac output, and a considerable increase in peripheral resistance; most vascular beds are constricted, and renal, splanchnic, cutaneous, and limb blood flows are reduced while coronary blood flow is increased. Phenelephrine also causes pulmonary vessel constriction and subsequent increase in pulmonary arterial pressure. Vasoconstriction in the mucosa of the respiratory tract leads to decreased edema and increased drainage of sinus cavities. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1A (chromosome 8), α1B (chromosome 5), and α1D (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of the α1-receptor activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on α1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the α1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities. Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

CNS Activity

Curator's Comment: Phenylephrine does not cross the blood–brain barrier

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
55.0 nM [EC50]
5.9 nM [EC50]
154.88 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
VAZCULEP

Approved Use

VAZCULEP (phenylephrine hydrochloride) is indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.

Launch Date

-5.05007997E11
Diagnostic
Phenylephrine Hydrochloride Ophthalmic Solution

Approved Use

Indicated to dilate the pupil

Launch Date

-9.7839363E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2959 pg/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
4492 pg/mL
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1354 pg/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2346 pg × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3900 pg × h/mL
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
955.8 pg × h/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.93 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.64 h
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.89 h
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENYLEPHRINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
10 mg 1 times / day multiple, oral
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy, 34 years
n = 1
Health Status: unhealthy
Age Group: 34 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Ischemic colitis...
AEs leading to
discontinuation/dose reduction:
Ischemic colitis (acute)
Sources:
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Disc. AE: Chest pain, Jaw pain...
Other AEs: Nervous system disorders, Headache...
AEs leading to
discontinuation/dose reduction:
Chest pain (1 patient)
Jaw pain (1 patient)
Other AEs:
Nervous system disorders (3.6%)
Headache (2.7%)
Gastrointestinal disorders (8%)
Dry mouth (2.7%)
Nausea (3.6%)
Sources:
10 % 3 times / day multiple, ophthalmic
Recommended
Dose: 10 %, 3 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 3 times / day
Sources:
healthy, > 1 year
Health Status: healthy
Age Group: > 1 year
Sources:
Other AEs: Eye pain, Blurred vision...
Other AEs:
Eye pain
Blurred vision
Photophobia
Allergic conjunctivitis
Sources:
250 ug single, intravenous
Recommended
Dose: 250 ug
Route: intravenous
Route: single
Dose: 250 ug
Sources:
unhealthy, adult
AEs

AEs

AESignificanceDosePopulation
Ischemic colitis acute
Disc. AE
10 mg 1 times / day multiple, oral
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy, 34 years
n = 1
Health Status: unhealthy
Age Group: 34 years
Sex: M
Population Size: 1
Sources:
Chest pain 1 patient
Disc. AE
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Jaw pain 1 patient
Disc. AE
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Dry mouth 2.7%
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Headache 2.7%
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Nausea 3.6%
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Nervous system disorders 3.6%
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Gastrointestinal disorders 8%
40 mg 6 times / day multiple, oral
Highest studied dose
Dose: 40 mg, 6 times / day
Route: oral
Route: multiple
Dose: 40 mg, 6 times / day
Sources:
unhealthy, 37.5 years (range: 19.0 - 77.0 years)
n = 112
Health Status: unhealthy
Condition: Seasonal Allergic Rhinitis
Age Group: 37.5 years (range: 19.0 - 77.0 years)
Sex: M+F
Population Size: 112
Sources:
Allergic conjunctivitis
10 % 3 times / day multiple, ophthalmic
Recommended
Dose: 10 %, 3 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 3 times / day
Sources:
healthy, > 1 year
Health Status: healthy
Age Group: > 1 year
Sources:
Blurred vision
10 % 3 times / day multiple, ophthalmic
Recommended
Dose: 10 %, 3 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 3 times / day
Sources:
healthy, > 1 year
Health Status: healthy
Age Group: > 1 year
Sources:
Eye pain
10 % 3 times / day multiple, ophthalmic
Recommended
Dose: 10 %, 3 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 3 times / day
Sources:
healthy, > 1 year
Health Status: healthy
Age Group: > 1 year
Sources:
Photophobia
10 % 3 times / day multiple, ophthalmic
Recommended
Dose: 10 %, 3 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 3 times / day
Sources:
healthy, > 1 year
Health Status: healthy
Age Group: > 1 year
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
PubMed

PubMed

TitleDatePubMed
Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice.
1999 Dec
[An unusual episode of angina].
1999 Mar
Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.
2000 Aug
Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release.
2000 Dec 1
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.
2000 Feb 15
Bupivacaine inhibits baroreflex control of heart rate in conscious rats.
2000 Jan
Fine structure and plasticity of barosensitive neurons in the nucleus of solitary tract.
2000 Jul 3
Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy.
2000 Jun
Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a.
2000 Mar
Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits.
2000 Mar 7
Heparin-mediated hypotension associated with cardiac surgery.
2000 Sep
Effects of salt intake and angiotensin II on vascular reactivity to endothelin-1.
2001 Feb
Reflex cardiovascular responses originating in exercising muscles of mice.
2001 Feb
Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility.
2001 Feb
Nitric oxide-mediated arteriolar dilation after endothelial deformation.
2001 Feb
Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control.
2001 Feb
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1.
2001 Feb
Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system.
2001 Feb
Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin.
2001 Feb 1
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Ras regulates NFAT3 activity in cardiac myocytes.
2001 Feb 2
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.
2001 Feb 7
Extracellular calcium-sensing receptor is expressed in rat hepatocytes. coupling to intracellular calcium mobilization and stimulation of bile flow.
2001 Feb 9
Detection and characterization of cholinergic oscillatory control in the forehead microvasculature in response to systemic alpha-agonist infusion in healthy volunteers.
2001 Jan
A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptors.
2001 Jan
Activity of cardiorespiratory networks revealed by transsynaptic virus expressing GFP.
2001 Jan
Involvement of Ca2+ -activated K+ channels in ginsenosides-induced aortic relaxation in rats.
2001 Jan
Effect of dietary vitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin-diabetic rats.
2001 Jan
Increased dilator response to heptanol and octanol in aorta from DOCA-salt-hypertensive rats.
2001 Jan
In vivo measurement of pulsewave velocity in small vessels using intravascular MR.
2001 Jan
Exercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculature.
2001 Jan
Catecholamine responses to alpha-adrenergic blockade during exercise in women acutely exposed to altitude.
2001 Jan
Should the angiotensin II antagonists be discontinued before surgery?
2001 Jan
Effects of acute and chronic hypertension on the labyrinthine barriers in rat.
2001 Jan
CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR.
2001 Jan
Acute hypertension inhibits thirst stimulated by ANG II, hyperosmolality, or hypovolemia in rats.
2001 Jan
[Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS.
2001 Jan
Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats.
2001 Jan
Inducible and neuronal nitric oxide synthase involvement in lipopolysaccharide-induced sphincteric dysfunction.
2001 Jan
Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle.
2001 Jan
Novel site-specific chemical delivery system as a potential mydriatic agent: formation of phenylephrine in the iris-ciliary body from phenylephrone chemical delivery systems.
2001 Jan
Receptor reserve analysis of the human alpha(2C)-adrenoceptor using.
2001 Jan 12
In vivo regulation of Na/Ca exchanger expression by adrenergic effectors.
2001 Mar
Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine.
2001 Mar
EDHF contributes to strain-related differences in pulmonary arterial relaxation in rats.
2001 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Also used as Ophthalmic Solution or oral tablets http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/203510s000lbl.pdf https://www.drugs.com/dosage/chlorpheniramine-phenylephrine.html
VAZCULEP (phenylephrine hydrochloride) Injection, 10 mg/mL, is injected intravenously either as a bolus or in a dilute solution as a continuous infusion. Dilute before administration. Dosing for treatment of hypotension during anesthesia Bolus intravenous injection: 40 mcg to 100 mcg every 1-2 minutes as needed, not to exceed 200 mcg. Intravenous infusion: 10 mcg/min to 35 mcg/min, titrating to effect, not to exceed 200 mcg/min.
Route of Administration: Intravenous
The hypertrophic phenotype of neonatal rat cardiomyocyte cultures (cardiomyocyte size, sarcomeric organization, total protein synthesis, c-fos expression) mediated by phenylephrine (10 uM) was counteracted by the selective A1 receptor agonist
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:38:33 UTC 2023
Edited
by admin
on Wed Jul 05 22:38:33 UTC 2023
Record UNII
1WS297W6MV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENYLEPHRINE
EP   HSDB   INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
J8.601K
Code English
M-SYMPATHOL
Common Name English
M-SYNEPHRINE
Common Name English
AB-101 (PHENYLEPHRINE)
Code English
(R)-PHENYLEPHRINE
Common Name English
(-)-3 HYDROXY-.ALPHA.-((METHYLAMINO)METHYL)BENZENEMETHANOL
Systematic Name English
PHENYLEPHRINE, (R)-
Common Name English
PHENYLEPHRINE MINIMS
Brand Name English
R(-)-MEZATON
Common Name English
PHENYLEPHRINE [HSDB]
Common Name English
(-)-1-(3-HYDROXYPHENYL)-2-METHYLAMINOETHANOL
Systematic Name English
M-OXEDRINE
Common Name English
Phenylephrine [WHO-DD]
Common Name English
PHENYLEPHRINE [VANDF]
Common Name English
PHENYLEPHRINE [MI]
Common Name English
META-SYNEPHRINE
Common Name English
phenylephrine [INN]
Common Name English
M-SYMPATOL
Common Name English
PHENYLEPHRINE [EP IMPURITY]
Common Name English
PHENYLEPHRINE [EP MONOGRAPH]
Common Name English
METASYNEPHRINE
Common Name English
(-)-PHENYLEPHRINE
Common Name English
PHENYLEPHRINE [MART.]
Common Name English
Classification Tree Code System Code
LIVERTOX 773
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QR01BA03
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QS01FB01
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QR01AA04
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QC01CA06
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC R01BA03
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC R01AB01
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC R01BA53
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QS01GA55
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC C01CA06
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC S01BB01
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QS01GA05
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QR01AB01
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC S01FB51
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC S01FB01
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
FDA ORPHAN DRUG 147201
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-VATC QR01BA53
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
NCI_THESAURUS C29709
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC S01GA55
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
NDF-RT N0000186105
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC R01AA04
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
WHO-ATC S01GA05
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
FDA ORPHAN DRUG 359011
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C62067
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
CAS
59-42-7
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
RXCUI
8163
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
MESH
D010656
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
ChEMBL
CHEMBL1215
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
RXCUI
325517
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
ALTERNATIVE
DAILYMED
1WS297W6MV
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
CHEBI
8093
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023465
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
IUPHAR
485
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
EVMPD
SUB09788MIG
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
HSDB
3383
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
DRUG BANK
DB00388
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
LACTMED
Phenylephrine
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
PUBCHEM
6041
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-424-8
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
DRUG CENTRAL
2146
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
NDF-RT
N0000009917
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY Adrenergic alpha1-Agonists [MoA]
FDA UNII
1WS297W6MV
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
MERCK INDEX
M8668
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY Merck Index
SMS_ID
100000088260
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
WIKIPEDIA
PHENYLEPHRINE
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
INN
4174
Created by admin on Wed Jul 05 22:38:33 UTC 2023 , Edited by admin on Wed Jul 05 22:38:33 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
Binding Assay
IC50
BINDER->LIGAND
BINDING
SALT/SOLVATE -> PARENT
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
RACEMATE -> ENANTIOMER
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Vdss PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC