BEREFRINE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C14H21NO2
Molecular Weight	235.322
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C[C@H](OC1C(C)(C)C)C2=CC(O)=CC=C2

InChI

InChIKey=ORIOFGXXYYXLNY-UEWDXFNNSA-N

InChI=1S/C14H21NO2/c1-14(2,3)13-15(4)9-12(17-13)10-6-5-7-11(16)8-10/h5-8,12-13,16H,9H2,1-4H3/t12-,13?/m0/s1

HIDE SMILES / InChI

Molecular Formula	C14H21NO2
Molecular Weight	235.322
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	1 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/?2008281 | https://www.ncbi.nlm.nih.gov/pubmed/8272415

Berefrine (also known as phenylephrine oxazolidine), a prodrug of phenylephrine, is a mydriatic agent. Berefrine was developed for improving ocular absorption and reducing systemic side effects.

Approval Year

PubMed

Title	Date	PubMed
Ocular pharmacokinetics and pharmacodynamics of phenylephrine and phenylephrine oxazolidine in rabbit eyes.	1990 May	2367315
Phenylephrine prodrug. Report of clinical trials.	1991 Feb	2008281

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:28:50 GMT 2023` Edited by `admin` on `Fri Dec 15 15:28:50 GMT 2023`
Record UNII	378U019DHG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BEREFRINE

Official Name

English

PHENOL, 3-(2-(1,1-DIMETHYLETHYL)-3-METHYL-5-OXAZOLIDINYL)-

Systematic Name

English

berefrine [INN]

Common Name

English

M-((2R,5R)-2-TERT-BUTYL-3-METHYL-5-OXAZOLIDINYL)PHENOL MIXTURE WITH M-((2S,5R)-2-TERT-BUTYL-3-METHYL-5-OXAZOLIDINYL)PHENOL

Common Name

English

BEREFRINE [USAN]

Common Name

English

3-((5R)-2-TERT-BUTYL-3-METHYL-1,3-OXAZOLIDIN-5-YL)PHENOL

Systematic Name

English

2-T-BUTYL-3-METHYL-5-(M-HYDROXYPHENYL)-1,3-OXAZOLIDINE

Systematic Name

English

BUREFRINE

Common Name

English

Code System Code Type Description

WIKIPEDIA

Berefrine