Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H18FN5O2 |
Molecular Weight | 355.3662 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1CNC(=O)C2=C3N=C(N[C@H](C)C4=CC(F)=CC=C4O1)C=CN3N=C2
InChI
InChIKey=FIKPXCOQUIZNHB-WDEREUQCSA-N
InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
Molecular Formula | C18H18FN5O2 |
Molecular Weight | 355.3662 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor. It represents an effective therapeutic option for patients with ROS1-, NTRK1-3-, or ALK-rearranged malignancies who have progressed on earlier-generation tyrosine kinase inhibitors. In June 2017, The US Food and Drug Administration (FDA) granted orphan drug designation to this drug for the treatment of Non–small cell lung adenocarcinoma with an ALK, ROS1, or NTRK mutation.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P08922 Gene ID: 6098.0 Gene Symbol: ROS1 Target Organism: Homo sapiens (Human) |
0.076 nM [IC50] | ||
Target ID: Q9UM73 Gene ID: 238.0 Gene Symbol: ALK Target Organism: Homo sapiens (Human) |
1.01 nM [IC50] | ||
Target ID: P12931 Gene ID: 6714.0 Gene Symbol: SRC Target Organism: Homo sapiens (Human) |
5.3 nM [IC50] | ||
Target ID: CHEMBL3559684 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:54:21 GMT 2023
by
admin
on
Sat Dec 16 11:54:21 GMT 2023
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Record UNII |
08O3FQ4UNP
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Record Status |
Validated (UNII)
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Record Version |
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-
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FDA ORPHAN DRUG |
573517
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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Code System | Code | Type | Description | ||
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10931
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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135565923
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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08O3FQ4UNP
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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C133821
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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FG-020
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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300000001945
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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1802220-02-5
Created by
admin on Sat Dec 16 11:54:21 GMT 2023 , Edited by admin on Sat Dec 16 11:54:21 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
IC50
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TARGET -> INHIBITOR |
IC50
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TARGET -> INHIBITOR |
IC50
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TARGET -> INHIBITOR |
IC50
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TARGET -> INHIBITOR |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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