U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 16:31:58 GMT 2025
Edited
by admin
on Tue Apr 01 16:31:58 GMT 2025
Protein Type RECEPTOR
Protein Sub Type KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
1L68U00N7O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GP140TRK
Preferred Name English
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR
Common Name English
TRK
Common Name English
MTC
Common Name English
TYROSINE KINASE RECEPTOR A
Common Name English
TROPOMYOSIN RECEPTOR KINASE A
Common Name English
NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1
Common Name English
TRKA
Common Name English
Code System Code Type Description
FDA UNII
1L68U00N7O
Created by admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
PRIMARY
PHAROS
P04629
Created by admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
PRIMARY
UNIPROT
P04629
Created by admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
PRIMARY
From To
1_122 1_159
1_183 1_233
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_35
N 1_63
N 1_89
N 1_156
N 1_170
N 1_221
N 1_230
N 1_249
N 1_286
N 1_291
N 1_306
N 1_326
N 1_369
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Mutation selectively disrupts the binding of hNGF to the p75NTR receptor while maintaining the affinity for the TrkA receptor. The R100 mutation abolishes the hyperalgesic effect that is usually associated with NGF without affecting most neurological functions.
AGONIST -> TARGET
Mediates neuronal survival.
INHIBITOR->OFF-TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Active against NTRK gene fusions. Competitive to ATP binding site.
COMPETITIVE INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
IC50
RADIOLIGAND->TARGET
Through a panel of 369 human kinases (no detectable kinase off-target at 1000-fold concentration over TrkB/C potency)
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_464] [1_644] [1_648] [1_649] [1_759] TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL