Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Thu Jul 06 17:10:17 UTC 2023
by
admin
on
Thu Jul 06 17:10:17 UTC 2023
|
| Protein Type | RECEPTOR |
| Protein Sub Type | KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
1L68U00N7O
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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1L68U00N7O
Created by
admin on Thu Jul 06 17:10:18 UTC 2023 , Edited by admin on Thu Jul 06 17:10:18 UTC 2023
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PRIMARY | |||
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P04629
Created by
admin on Thu Jul 06 17:10:18 UTC 2023 , Edited by admin on Thu Jul 06 17:10:18 UTC 2023
|
PRIMARY | |||
|
P04629
Created by
admin on Thu Jul 06 17:10:18 UTC 2023 , Edited by admin on Thu Jul 06 17:10:18 UTC 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_122 | 1_159 |
| 1_183 | 1_233 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_35 |
| N | 1_63 |
| N | 1_89 |
| N | 1_156 |
| N | 1_170 |
| N | 1_221 |
| N | 1_230 |
| N | 1_249 |
| N | 1_286 |
| N | 1_291 |
| N | 1_306 |
| N | 1_326 |
| N | 1_369 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Active against NTRK gene fusions. Competitive to ATP binding site.
COMPETITIVE INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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INHIBITOR -> TARGET |
IC50
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AGONIST -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
![Structure of N-{2-[4-(2-Amino-5-chloropyridin-3-yl)phenoxy]pyrimidin-5-yl}-N'-[2-(methanesulfonyl)-5-(trifluoromethyl)phenyl]urea](/img/5075ce59-130d-48e4-9858-5a6018f15160.svg "Structure of N-{2-[4-(2-Amino-5-chloropyridin-3-yl)phenoxy]pyrimidin-5-yl}-N'-[2-(methanesulfonyl)-5-(trifluoromethyl)phenyl]urea")
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|