Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 16:31:58 GMT 2025
by
admin
on
Tue Apr 01 16:31:58 GMT 2025
|
| Protein Type | RECEPTOR |
| Protein Sub Type | KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
1L68U00N7O
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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1L68U00N7O
Created by
admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
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PRIMARY | |||
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P04629
Created by
admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
|
PRIMARY | |||
|
P04629
Created by
admin on Tue Apr 01 16:31:58 GMT 2025 , Edited by admin on Tue Apr 01 16:31:58 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_122 | 1_159 |
| 1_183 | 1_233 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_35 |
| N | 1_63 |
| N | 1_89 |
| N | 1_156 |
| N | 1_170 |
| N | 1_221 |
| N | 1_230 |
| N | 1_249 |
| N | 1_286 |
| N | 1_291 |
| N | 1_306 |
| N | 1_326 |
| N | 1_369 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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AGONIST -> TARGET |
Mutation selectively disrupts the binding of hNGF to the p75NTR receptor while maintaining the affinity for the TrkA receptor. The R100 mutation abolishes the hyperalgesic effect that is usually associated with NGF without affecting most neurological functions.
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AGONIST -> TARGET |
Mediates neuronal survival.
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INHIBITOR->OFF-TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Active against NTRK gene fusions. Competitive to ATP binding site.
COMPETITIVE INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
IC50
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RADIOLIGAND->TARGET |
Through a panel of 369 human kinases (no detectable kinase off-target at 1000-fold concentration over TrkB/C potency)
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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AGONIST -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_464] [1_644] [1_648] [1_649] [1_759] | TYROSINE O-PHOSPHATE | 2R86C98KDX |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|