U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Fri Jun 25 21:36:10 UTC 2021
Edited
by admin
on Fri Jun 25 21:36:10 UTC 2021
Protein Type RECEPTOR
Protein Sub Type KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
1L68U00N7O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR
Common Name English
TRK
Common Name English
GP140TRK
Common Name English
MTC
Common Name English
TYROSINE KINASE RECEPTOR A
Common Name English
TROPOMYOSIN RECEPTOR KINASE A
Common Name English
NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1
Common Name English
TRKA
Common Name English
Code System Code Type Description
FDA UNII
1L68U00N7O
Created by admin on Fri Jun 25 21:36:10 UTC 2021 , Edited by admin on Fri Jun 25 21:36:10 UTC 2021
PRIMARY
PHAROS
P04629
Created by admin on Fri Jun 25 21:36:10 UTC 2021 , Edited by admin on Fri Jun 25 21:36:10 UTC 2021
PRIMARY
UNIPROT
P04629
Created by admin on Fri Jun 25 21:36:10 UTC 2021 , Edited by admin on Fri Jun 25 21:36:10 UTC 2021
PRIMARY
From To
1_122 1_159
1_183 1_233
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_35
N 1_63
N 1_89
N 1_156
N 1_170
N 1_221
N 1_230
N 1_249
N 1_286
N 1_291
N 1_306
N 1_326
N 1_369
Related Record Type Details
INHIBITOR -> TARGET
Active against NTRK gene fusions. Competitive to ATP binding site.
COMPETITIVE INHIBITOR
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL