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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H32N6O11
Molecular Weight 580.5445
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAVILERMIDE

SMILES

NCCCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C2=C(OCC[C@H](NC1=O)C(=O)NCC(O)=O)C=CC(=C2)[N+]([O-])=O

InChI

InChIKey=DVJXNXPFYJIACK-ULQDDVLXSA-N
InChI=1S/C24H32N6O11/c25-9-2-1-3-15-23(37)29-17(22(36)26-12-20(33)34)8-10-41-18-6-4-13(30(39)40)11-14(18)21(35)27-16(24(38)28-15)5-7-19(31)32/h4,6,11,15-17H,1-3,5,7-10,12,25H2,(H,26,36)(H,27,35)(H,28,38)(H,29,37)(H,31,32)(H,33,34)/t15-,16-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula C24H32N6O11
Molecular Weight 580.5445
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Tavilermide (also known as MIM-D3) was developed as a tyrosine kinase TrkA receptor agonist for the treatment of patients with dry eye. The drug was studied in phase III clinical trial in treating the signs and symptoms of dry eye. In addition, was assumed that tavilermide could be studied for glaucoma.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
A total of 150 dry eye patients were randomized 1:1:1 to study medication (1% MIM-D3 (TAVILERMIDE), 5% MIM-D3, or placebo) and dosed twice daily (BID) for 28 days.
Route of Administration: Other
Substance Class Chemical
Record UNII
NMG938VJ6T
Record Status Validated (UNII)
Record Version