CHF-6467

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:56:23 GMT 2025` Edited by `admin` on `Wed Apr 02 20:56:23 GMT 2025`
Protein Type	GROWTH FACTOR
Protein Sub Type	NERVE GROWTH FACTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	4DL2E33KNV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHF6467

Preferred Name

English

CHF-6467

Code

English

Nerve growth factor P61S/R100E

Common Name

English

hNGF P61S/R100E

Common Name

English

mutated human nerve growth factor CHF6467

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C200308

Created by admin on Wed Apr 02 20:56:23 GMT 2025 , Edited by admin on Wed Apr 02 20:56:23 GMT 2025

PRIMARY

FDA UNII

4DL2E33KNV

Created by admin on Wed Apr 02 20:56:23 GMT 2025 , Edited by admin on Wed Apr 02 20:56:23 GMT 2025

PRIMARY

From	To
1_15	1_80
2_15	2_80
1_58	1_108
2_58	2_108
1_68	1_110
2_68	2_110

Related Record Type Details


					042U4WAS57

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16

OFF TARGET->NON-INHIBITOR

Comments:

Mutation (R100E) selectively disrupts the binding of hNGF to the p75NTR receptor while maintaining the affinity for the TrkA receptor.

Amount:


					1L68U00N7O

HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR

TARGET -> AGONIST

Comments:

Mutation selectively disrupts the binding of hNGF to the p75NTR receptor while maintaining the affinity for the TrkA receptor. The R100 mutation abolishes the hyperalgesic effect that is usually associated with NGF without affecting most neurological functions.

Amount:

Related Record Type Details


					4DL2E33KNV

CHF-6467

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL

Molecular Formula	CHEMICAL