HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR G667C

Approval Year

Substance Class	Protein
Protein Type	RECEPTOR
Protein Sub Type	KINASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	WCR7XT3U92
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRKA G667C

Preferred Name

English

HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR G667C

Common Name

English

TYROSINE KINASE RECEPTOR A G667C

Common Name

English

TROPOMYOSIN RECEPTOR KINASE A G667C MUTANT

Common Name

English

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Code System

Code

Type

Description

FDA UNII

WCR7XT3U92

PRIMARY

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From	To
1_122	1_159
1_183	1_233

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_35
N	1_63
N	1_89
N	1_156
N	1_170

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Related Record

Type

Details


					0J45910S3X

SELITRECTINIB

WEAK INHIBITOR->TARGET

Amount:

110 NANOMOLAR [100 to 120] (average)


					A82VU8JCU6

LPM-4870108

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

2.3 NANOMOLAR [2 to 2.6] (average)


					08O3FQ4UNP

REPOTRECTINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

8.7 NANOMOLAR [7.9 to 9.5] (average)

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_464] [1_644] [1_648] [1_649] [1_759]				TYROSINE O-PHOSPHATE	2R86C98KDX

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL	ESTIMATED C3745H5837N1050O1108P5S38

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