Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 16:53:21 GMT 2025
by
admin
on
Tue Apr 01 16:53:21 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
G0D1L6VX5I
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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Q16288
Created by
admin on Tue Apr 01 16:53:21 GMT 2025 , Edited by admin on Tue Apr 01 16:53:21 GMT 2025
|
PRIMARY | |||
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G0D1L6VX5I
Created by
admin on Tue Apr 01 16:53:21 GMT 2025 , Edited by admin on Tue Apr 01 16:53:21 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_289 | 1_331 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_41 |
| N | 1_48 |
| N | 1_102 |
| N | 1_132 |
| N | 1_172 |
| N | 1_187 |
| N | 1_201 |
| N | 1_228 |
| N | 1_236 |
| N | 1_241 |
| N | 1_263 |
| N | 1_344 |
| N | 1_357 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVATOR -> TARGET | |||
|
INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Highly selective: limited inhibition of other kinases and >1,000x selective over other off targets
COMPETITIVE INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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RADIOLIGAND->TARGET |
Through a panel of 369 human kinases (no detectable kinase off-target at 1000-fold concentration over TrkB/C potency)
IC50
|
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_485] [1_674] [1_678] [1_679] | TYROSINE O-PHOSPHATE | 2R86C98KDX | |||
| AMINO ACID SUBSTITUTION | [1_462] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|