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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C4H5NO4.Mg.2H
Molecular Weight 288.4945
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM ASPARTATE ANHYDROUS

SMILES

[H+].[H+].[Mg++].N[C@@H](CC([O-])=O)C([O-])=O.N[C@@H](CC([O-])=O)C([O-])=O

InChI

InChIKey=RXMQCXCANMAVIO-CEOVSRFSSA-L
InChI=1S/2C4H7NO4.Mg/c2*5-2(4(8)9)1-3(6)7;/h2*2H,1,5H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*2-;/m00./s1

HIDE SMILES / InChI
Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C4H6NO4
Molecular Weight 132.0947
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Sources: https://www.drugs.com/dosage/magnesium-lactate.htmlhttps://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttps://www.ncbi.nlm.nih.gov/pubmed/351265https://www.drugs.com/ppa/magnesium-chloride.htmlhttp://www.db-pharma.com/anglais/49.pdfhttps://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1http://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfdoi: 10.1081/SCC-120022479DOI: 10.2903/j.efsa.2008.883https://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640
Curator's Comment: description was created based on several sources, including: https://www.blackmores.com.au/products/magmin | https://www.ncbi.nlm.nih.gov/pubmed/25262412 |http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf

Magnesium diamide is used as a chemical intermediate. Magnesium diamide is spontaneously combustible. It is toxic by inhalation. Skin or eye contact may cause severe burns.

CNS Activity

Originator

Ulex, G.L.
66
Curator's Comment: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845

Approval Year

1921
1468
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
Modulator
846
Modulator
846
Modulator
846
Modulator
846
Interacts
323
Protein S100-A8
66
Target ID: P05109
Gene ID: 6279.0
Gene Symbol: S100A8
Target Organism: Homo sapiens (Human)
Binding Agent
1076
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Preventing
Approved
8583
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Primary
Approved
8583
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Diagnostic
Approved
8583
ColPrep Kit

Approved Use

INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults

Launch Date

2016
Primary
Phase III
665
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

1995
Curative
Approved
8583
MagMin

Approved Use

Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Curative
Not Provided
511
DELBIASE

Approved Use

Unknown
Primary
Not Provided
511
DELBIASE

Approved Use

Unknown
Primary
Not Provided
511
DELBIASE

Approved Use

Unknown
Curative
Approved
8583
Magnesium Chloride

Approved Use

Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Palliative
Phase II
1147
Magnesium Chloride

Approved Use

Unknown
Palliative
Phase III
665
Magnesium Chloride

Approved Use

Unknown
Primary
Approved
8583
EPIMAG

Approved Use

Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Primary
Approved
8583
EPIMAG

Approved Use

Used to relief of occasional constipation (irregularity).
Curative
Approved
8583
Magnesium Citrate

Approved Use

Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Curative
Approved
8583
Unknown

Approved Use

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.
PubMed

PubMed

TitleDatePubMed
[Magnesium--an alternative in treatment resistant tachyarrhythmias].
1977 May 30
Characterization of the prolactin receptor in human prostate.
1983 Nov
Hypomagnesaemic tetany associated with prolonged treatment with aminoglycosides.
1986 Mar 22
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.
1989 Jun 15
Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.
1990 Feb 5
Persistent paralysis in critically ill patients after long-term administration of vecuronium.
1992 Aug 20
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.
1995 Mar
Struvite stones.
1999
Magnesium and cardiovascular drugs: interactions and therapeutic role.
1999 Jan-Mar
Influence of maternal magnesium sulphate and ritodrine treatment on the neonate: a study with six-month follow-up.
1999 Oct
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.
2000 Aug
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats.
2000 Jul
Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.
2000 Nov
Complement activation in factor D-deficient mice.
2001 Dec 4
Effect of maternal tocolysis on the incidence of severe periventricular/intraventricular haemorrhage in very low birthweight infants.
2001 Jul
Evidence supporting a role for KCl cotransporter in the thick ascending limb of Henle's loop.
2001 Nov
Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells.
2001 Sep 28
Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed.
2002 Jul
Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.
2002 Nov
Enhancement of endotoxin-induced vascular hyporeactivity to phenylephrine in the thoracic aortas of Mg-deficient rats ex vivo.
2003 Oct 10
The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium.
2004 Aug
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two cases.
2005 Jan
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
2005 Oct
An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence.
2006 Apr
Formation of formal disilene fluoride adducts.
2008 Dec 24
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).
2010 Apr 13
Cardiac effects of magnesium sulfate pretreatment on acute dichlorvos-induced organophosphate poisoning: an experimental study in rats.
2010 Feb
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.
2011 May 30
Tris(oxazolinyl)boratomagnesium-catalyzed cross-dehydrocoupling of organosilanes with amines, hydrazine, and ammonia.
2011 Oct 26
Magnesium chloride tetrahydrate, MgCl2·4H2O.
2012 Jan
Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.
2013 Apr
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.
2013 Feb 25
Catalytic contribution of threonine 244 in human ALDH2.
2013 Feb 25
MgI2 -mediated chemoselective cleavage of protecting groups: an alternative to conventional deprotection methodologies.
2015 Jul 27
Single-day sodium picosulfate and magnesium citrate versus split-dose polyethylene glycol for bowel cleansing prior to colonoscopy: A prospective randomized endoscopist-blinded trial.
2015 Nov
Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats.
2016
A Soft Grip: Magnesium Complexes with a Phosphine-Modified Phosphonium Diylidic Lewis Base.
2016 Nov 21
In vitro and in vivo evaluation of MgF(2) coated AZ31 magnesium alloy porous scaffolds for bone regeneration.
2017 Jan 1
Fast sono assisted ferrofluid mediated silver super - Adsorption over magnesium ferrite-copper sulfide chalcogenide with the aid of multivariate optimization.
2017 Jul
Magnesium lactate in the treatment of Gitelman syndrome: patient-reported outcomes.
2017 Mar 1
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates.
2017 Oct
Patents

Patents

03931199
72
03931205
77
03931302
69
03932463
70
03932472
89
03932479
113
03932483
75
03932524
68
03933824
70
03935253
66
03935271
69
03936470
98
03939091
68
03944589
66
03950406
119
03950427
70
03950525
67
03957788
66
03960906
66
03960907
67
03961066
66
03963724
66
03965143
66
03966648
67
03966773
135
03968231
67
03969368
66
03969384
66
03973022
77
03973030
67
03978121
74
03978129
66
03978130
66
03980795
66
03981917
74
03982001
66
03983164
67
03985729
66
03985817
66
03987009
96
03987091
67
03988205
66
03989724
72
03989749
68
03989841
66
03991106
66
03993773
66
03994961
66
03995054
67
03995056
70
03998834
70
04005147
106
04045433
67
04059595
66
04088772
67
04144333
66
04156786
66
04289816
66
04341767
67
04454357
66
04471070
66
04540815
66
04546195
66
04569941
66
04577011
67
04585885
67
04599341
66
04661260
68
04725688
68
04734420
74
04916235
70
04935430
66
04990319
66
05012019
66
05177240
66
05206229
66
05275950
67
05326548
66
05389640
67
05451591
67
05633237
66
05658908
68
05719148
82
05786353
67
05859290
66
05929067
67
06017928
73
06040331
66
06051712
73
06100275
67
06150526
73
06156767
66
06274737
68
06380218
73
06540905
67
06613708
66
06812355
66
07230017
69
07402595
70
07445915
66
07557213
67
07601736
66
07691842
69
08236943
66
08383835
66
20050130276
66
20060100207
66
20100267970
66
CN106582743
66
DE1110825
66
EP1810974A1
66
EP2259773A1
66
EP2708510A1
66
EP2714042A1
66
US1913539
66
US20060083725
66
US20140076804
66
US2034070
66
US2260004
66
US2877095
66
US3030184
66
US3320048
66
US3377271
66
US3429777
66
US3476510
66
US3760050
66
US3994859
66
US4111835
66
US4535183
66
US4748283
66
US4959222
66
US7182872
66
US7608239
66
US9334166
66
WO2000050046A1
66
WO2005123647A1
68

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Magnesium Chloride
Magnesium lactate is used as a dietary supplement (200-400 mg of elemental magnesium per day for adults).
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Magnesium Chloride
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:04:24 GMT 2025
Edited
by admin
on Mon Mar 31 21:04:24 GMT 2025
Record UNII
082H981FMA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAGNESIUM ASPARTATE ANHYDROUS
Common Name English
MAGNESIUM HYDROGEN ASPARTATE
WHO-DD  
Preferred Name English
Magnesium aspartate [WHO-DD]
Common Name English
MAGNESIUM L-ASPARTATE
JAN  
Systematic Name English
L-ASPARTIC ACID, MAGNESIUM SALT (2:1)
Common Name English
MAGNESIUM DIASPARTATE
Systematic Name English
(+)-MAGNESIUM ASPARTATE ANHYDROUS
Common Name English
CARDIOPLEGIN COMPONENT MAGNESIUM ASPARTATE ANHYDROUS
Common Name English
MAGNESIUM L-ASPARTATE [JAN]
Common Name English
MAGNESIUM HYDROASPARTATE
Common Name English
MAGNESATE(2-), BIS(L-ASPARTATO(2-)-.KAPPA.N,.KAPPA.O1)-, HYDROGEN (1:2), (T-4)-
Systematic Name English
ASPARTIC ACID, MAGNESIUM SALT (2:1), L-
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
218-191-6
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
ALTERNATIVE
CAS
18962-61-3
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
SMS_ID
100000076817
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
EPA CompTox
DTXSID10273965
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
DAILYMED
082H981FMA
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
ECHA (EC/EINECS)
242-703-7
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
CAS
2068-80-6
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
ALTERNATIVE
PUBCHEM
87869
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
EVMPD
SUB14415MIG
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
FDA UNII
082H981FMA
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
RXCUI
1792467
Created by admin on Mon Mar 31 21:04:24 GMT 2025 , Edited by admin on Mon Mar 31 21:04:24 GMT 2025
PRIMARY
Related Record Type Details
Structure of ASPARTIC ACID
PARENT -> SALT/SOLVATE
Structure of MAGNESIUM ASPARTATE
SOLVATE->ANHYDROUS
Structure of MAGNESIUM ASPARTATE DIHYDRATE
SOLVATE->ANHYDROUS
Related Record Type Details
Structure of MAGNESIUM CATION
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