MAGNESIUM CITRATE DIBASIC

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H5O7.Mg.H
Molecular Weight	214.4126
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[Mg++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=DIXGJWCZQHXZNR-UHFFFAOYSA-L

InChI=1S/C6H8O7.Mg/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+2/p-2

HIDE SMILES / InChI

Description
Sources: http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://www.db-pharma.com/anglais/49.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttps://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640DOI: 10.2903/j.efsa.2008.883http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfdoi: 10.1081/SCC-120022479https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1https://www.drugs.com/ppa/magnesium-chloride.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9https://www.drugs.com/dosage/magnesium-lactate.htmlhttp://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/351265
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/9873215 | http://discovery.ucl.ac.uk/1336882/1/1336882.pdf

Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
action potential 66 Target ID: GO:0001508 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12225296	Inhibitor 8297
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/26812001	Modulator 828
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webmd.com/drugs/2/drug-10702-5106/magnesium-dr/details	Modulator 828
oxalate metabolic process 66 Target ID: GO:0033609 Sources: https://www.medicinep.com/epimag-for-cases-of-oxaluria-and-mild-laxative-to-relieve-constipation-2918.html	Modulator 828
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Modulator 828
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc \| https://www.drugs.com/mtm/magnesium-lactate.html	Interacts 323
Protein S100-A8 66 Target ID: P05109 Gene ID: 6279.0 Gene Symbol: S100A8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8061680	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Bone disease 70 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27792982	Primary	Basic research	Unknown Approved Use Unknown
Bacterial infections 234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27995243	Primary	Preclinical	Unknown Approved Use Unknown
Bronchial spasm 78 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20647692	Primary	Preclinical	Unknown Approved Use Unknown
Unknown 2578
Unknown 2578
Unknown 2578
Preeclampsia 85 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Preventing	Approved 8429	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Eclampsia 69 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Primary	Approved 8429	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Preparation for colonoscopy 66 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204553s001lbl.pdf	Diagnostic	Approved 8429	ColPrep Kit Approved Use INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults Launch Date 2016
Atrial fibrillation 131 Sources: https://clinicaltrials.gov/ct2/show/NCT00965874	Primary	Phase III 656	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Unknown 2578
Magnesium deficiency 67 Sources: https://www.blackmores.com.au/products/magmin	Curative	Approved 8429	MagMin Approved Use Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Unknown 2578
Magnesium deficiency 67 Sources: http://www.db-pharma.com/anglais/49.pdf	Curative	Not Provided 504	DELBIASE Approved Use Unknown
Eclampsia 69 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 504	DELBIASE Approved Use Unknown
Convulsions 72 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 504	DELBIASE Approved Use Unknown
Magnesium deficiency 67 Sources: http://www.meritpharm.com/wp-content/uploads/2014/03/Chloromag.Magnesium-Chloride.MSDS_.pdf	Curative	Approved 8429	Magnesium Chloride Approved Use Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Fibromyalgia 89 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26343101	Palliative	Phase II 1132	Magnesium Chloride Approved Use Unknown
Stroke 144 Sources: https://clinicaltrials.gov/ct2/show/NCT00933868	Palliative	Phase III 656	Magnesium Chloride Approved Use Unknown
Oxaluria 66 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8429	EPIMAG Approved Use Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Constipation 112 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8429	EPIMAG Approved Use Used to relief of occasional constipation (irregularity).
Magnesium deficiency 67 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Curative	Approved 8429	Magnesium Citrate Approved Use Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Unknown 2578
Magnesium deficiency 67 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc https://www.drugs.com/mtm/magnesium-lactate.html	Curative	Approved 8429	Unknown Approved Use Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

PubMed

Title	Date	PubMed
[Magnesium--an alternative in treatment resistant tachyarrhythmias].	1977 May 30	867390
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.	1979 Nov	496555
Characterization of the prolactin receptor in human prostate.	1983 Nov	6197504
Symptomatic hypercalcaemia precipitated by magnesium therapy.	1985 Jan	3991404
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.	1986 Sep	3527812
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.	1987 Mar 30	3566749
A comparison of two digestion procedures for the determination of selenium in biological material.	1987 Oct	18964415
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.	1989 Jun 15	2542339
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].	1989 Sep	2510412
Role of magnesium in cardiac tachyarrhythmias.	1990 Jun 19	2353670
Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine.	1991 Jun	2042788
Sotalol-induced torsade de pointes: management with magnesium infusion.	1992 Apr	1409197
Persistent paralysis in critically ill patients after long-term administration of vecuronium.	1992 Aug 20	1353252
[Heart rate disorders in potassium and magnesium deficiency].	1992 Sep 7	1413169
['Cardiac ballet' with and without amiodarone].	1993 Jan 13	8421775
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.	1994 Feb 18	8106444
Cocaine-induced cerebrovasospasm and its possible mechanism of action.	1994 Mar	8138965
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.	1995 Mar	7891159
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.	2000 Aug	10913914
Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.	2000 Dec	11145159
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats.	2000 Jul	10930190
An efficient chiral moderator prepared from inexpensive (+)-3-carene: synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963.	2000 Oct 5	11009360
Familial hypomagnesemia--hypercalciuria and pseudotumor cerebri.	2001	15503623
Complement activation in factor D-deficient mice.	2001 Dec 4	11724962
Magnesium bromide mediated highly diastereoselective heterogeneous hydrogenation of olefins.	2002 Apr 18	11950359
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.	2002 Sep 6	12065575
Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro.	2003 Nov	14636342
Enhancement of endotoxin-induced vascular hyporeactivity to phenylephrine in the thoracic aortas of Mg-deficient rats ex vivo.	2003 Oct 10	13679239
Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis.	2004 Aug	15039145
A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.	2004 May	15068510
Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction.	2006	17067136
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.	2006 Feb	16269826
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.	2006 Jun 20	16768462
Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers.	2006 Oct	17167544
Formation of formal disilene fluoride adducts.	2008 Dec 24	19053480
[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].	2008 Jul	18767395
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect.	2009 Dec	19922557
Differential binding of inorganic particles to MARCO.	2009 Jan	18836211
AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.	2009 Jun	19484392
The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation.	2009 Jun 23	19405516
Hair tissue mineral analysis and metabolic syndrome.	2009 Sep	19221698
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins.	2011 Jan	21126535
C-H functionalization polycondensation of chlorothiophenes in the presence of nickel catalyst with stoichiometric or catalytically generated magnesium amide.	2011 Jun 29	21634794
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.	2011 May 30	21276780
Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.	2013 Apr	23415960
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes.	2013 Feb 15	23274517
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.	2013 Feb 25	23295229
Catalytic contribution of threonine 244 in human ALDH2.	2013 Feb 25	23295226
A Soft Grip: Magnesium Complexes with a Phosphine-Modified Phosphonium Diylidic Lewis Base.	2016 Nov 21	27775201
In vitro and in vivo evaluation of MgF(2) coated AZ31 magnesium alloy porous scaffolds for bone regeneration.	2017 Jan 1	27792982

Patents

Sample Use Guides

In Vivo Use Guide

Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm were used for the deposition of Magnesium Fluoride (MgF2) film.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

MAGNESIUM CITRATE DIBASIC

Common Name

English

CITRESIA

Brand Name

English

EPIMAG

Brand Name

English

MAGNESIUM HYDROGEN CITRATE

Systematic Name

English

MAGNESIUM CITRATE DIBASIC [MI]

Common Name

English

ACID MAGNESIUM CITRATE

Common Name

English

CITRONEMA

Brand Name

English

MAGNESIUM CITRATE, DIBASIC

Common Name

English

1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, MAGNESIUM SALT (1:1)

Common Name

English

CITRIC ACID, MAGNESIUM SALT (1:1)

Common Name

English

Code System Code Type Description

EVMPD

SUB130546