U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants.
1985 Feb
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
1993 Jul
Dietary calcium and manganese effects on menstrual cycle symptoms.
1993 May
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.
2001 Jun 18
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.
2005 Mar
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
2005 May
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
2007 Jun
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.
2009 Sep
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.
2013 Aug
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.
2016 Nov
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.
2017 Apr 12
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.
2017 Apr 7
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Name Type Language
MANGANESE GLUCONATE, UNSPECIFIED FORM
Common Name English
MANGANESE GLUCONATE
EP   INCI   MART.   USP   VANDF   WHO-DD  
INCI  
Preferred Name English
MANGANESE GLUCONATE [USP MONOGRAPH]
Common Name English
MANGANESE GLUCONATE [VANDF]
Common Name English
MANGANESE GLUCONATE [MART.]
Common Name English
MANGANESE GLUCONATE IS DRIED OR CONTAINS TWO MOLECULES OF WATER OF HYDRATION
Common Name English
MANGANESE GLUCONATE [EP MONOGRAPH]
Common Name English
MANGANUM GLUCONICUM
Common Name English
Manganese gluconate [WHO-DD]
Common Name English
MANGANESE GLUCONATE [INCI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1452
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
Code System Code Type Description
RXCUI
52403
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
PRIMARY RxNorm
DAILYMED
9YY2F980SV
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
PRIMARY
DRUG BANK
DB11141
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
PRIMARY
FDA UNII
9YY2F980SV
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
PRIMARY
EVMPD
SUB14471MIG
Created by admin on Fri Dec 15 20:07:55 GMT 2023 , Edited by admin on Fri Dec 15 20:07:55 GMT 2023
PRIMARY
Definition References