DescriptionSources: http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.alfa.com/en/catalog/032808/https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367https://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://google.com/patents/CN104529454A?Curator's Comment: description was created based on several sources, including
http://www.sciencedirect.com/science/article/pii/S002202480400507X | https://www.ncbi.nlm.nih.gov/pubmed/7284642
Sources: http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.alfa.com/en/catalog/032808/https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367https://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://google.com/patents/CN104529454A?
Curator's Comment: description was created based on several sources, including
http://www.sciencedirect.com/science/article/pii/S002202480400507X | https://www.ncbi.nlm.nih.gov/pubmed/7284642
Manganese Difluoride is a light pink crystalline solid composed of manganese and fluoride with the formula MnF2. Manganese Difluoride is made by treating manganese and diverse compounds of manganese(II) in hydrofluoric acid. Manganese Difluoride is used in the manufacture of special kinds of glass and lasers.
Originator
Sources: https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19610920&CC=GB&NR=877677A&KC=Ahttps://www.americanelements.com/manganese-ii-iodide-7790-33-2http://www.newworldencyclopedia.org/entry/Manganese
Curator's Comment: Manganese was first discovered by Torbern Olof Bergman in 1770 and first isolated by Johann Gottlieb Gahn in 1774.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1075097 |
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Target ID: CHEMBL1795148 |
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Target ID: CHEMBL4612 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseManganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese. |
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| Primary | Unknown Approved UseManganese is used for weak bones (osteoporosis). |
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| Palliative | Unknown Approved UseEarly research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension. |
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| Curative | MANGANESE SULFATE Approved UseManganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms. |
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| Primary | MANGANESE SULFATE Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of fluoride on copper, manganese and zinc in bone and kidney. | 1981 Mar |
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| Differential ability of transition metals to induce pulmonary inflammation. | 2001 Nov 15 |
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| Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate. | 2002 Sep |
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| CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters. | 2006 Nov 27 |
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| Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip. | 2013 Aug |
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| Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics. | 2014 May |
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| Controlled Synthesis of Hollow Manganese Oxide Nanocrystals. | 2016 Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
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CFR |
21 CFR 184.1452
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52403
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DB11141
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SUB14471MIG
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One of these components may be present:
ACTIVE MOIETY
SUBSTANCE RECORD
