U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Na.HO
Molecular Weight 39.9971
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sodium hydroxide

SMILES

[OH-].[Na+]

InChI

InChIKey=HEMHJVSKTPXQMS-UHFFFAOYSA-M
InChI=1S/Na.H2O/h;1H2/q+1;/p-1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

2010
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Approved
8429
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

1958
PubMed

PubMed

TitleDatePubMed
Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.
1994 Sep 30
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997 Aug 15
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
1997 Nov
Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1.
1998 Jun
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Role of aquaporin water channels in pleural fluid dynamics.
2000 Dec
Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.
2000 Oct
Interactions of growth inhibitory factor with hydroxyl and superoxide radicals.
2003 Sep
[Water permeability of the OMCD and IMCD cells' basolateral membrane under the conditions of dehydration and dDAVP action].
2004 Jul
Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney.
2004 Oct
Effect of dioxane on the structure and hydration-dehydration of alpha-chymotrypsin as measured by FTIR spectroscopy.
2005 Jun 15
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.
2005 Sep
Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.
2006 Feb
Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample.
2006 Jun
The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first?
2006 Oct 30
Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions.
2007 Dec
Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.
2007 Jun 1
A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell.
2009 Feb
Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata).
2009 Nov
Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.
2010 Apr 21
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.
2011 Apr 1
Inhibition of aquaporin-3 water channel in the colon induces diarrhea.
2012
A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.
2012 May
Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD).
2012 Sep
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
2013 Feb
Patents

Patents

03930837
22
03931170
10
03931193
12
03931205
82
03931226
16
03931231
17
03931247
15
03932424
12
03932446
10
03932452
10
03932471
13
03932472
94
03932521
29
03932629
11
03933865
12
03933905
18
03933911
10
03934070
10
03937702
41
03937705
11
03937719
10
03937729
10
03937764
10
03939157
10
03939202
15
03940396
10
03940419
12
03941796
50
03941799
14
03941884
10
03943145
12
03943170
10
03943180
12
03946000
40
03946045
11
03947406
32
03947408
15
03947580
12
03950331
20
03950382
10
03950420
10
03950425
13
03952012
15
03952017
13
03952050
12
03952067
11
03953434
43
03953525
11
03953596
12
03954476
17
03954774
11
03954801
15
03956118
10
03956321
10
03959289
11
03970704
12
04002647
12
04008269
12
04029867
10
04128728
11
04134924
10
04136188
10
04511731
10
04532240
10
04568497
11
04691042
10
04826533
11
04844879
10
05187175
10
05302718
13
05403930
11
05527805
11
05556855
13
05607951
10
05658926
10
06156430
10
06649600
13
06703082
10
07250518
10
07354941
35
07494728
11
07655666
10
08012988
10
08436001
13
08481733
14
08501238
10
08513268
10
08614206
10
08669361
12
08741915
12
20030186989
11
20080153836
11
20090120802
11
20090286768
10
20100144747
11
20110251176
10
20110294818
10
20120208817
10
20130079321
10
20130203732
10
20130217666
10
7820025
11

Sample Use Guides

In Vivo Use Guide
10% Potassium Hydroxide
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
Sodium hydroxide
EP   FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
INS-524
Code English
SODIUM HYDROXIDE [EP MONOGRAPH]
Common Name English
SODIUM HYDROXIDE [MI]
Common Name English
CAUSTIC SODA
Common Name English
SODIUM HYDROXIDE [JAN]
Common Name English
LYE
Common Name English
PROMOTER 3308B
Brand Name English
SODIUM HYDROXIDE SOLUTIONS [FCC]
Common Name English
SODIUM HYDROXIDE SOLUTIONS
FCC  
Common Name English
AETZNATRON
Common Name English
TOSOH PEARL
Brand Name English
NSC-135799
Code English
SODIUM HYDROXIDE [FCC]
Common Name English
SODIUM HYDROXIDE [MART.]
Common Name English
SODIUM HYDROXIDE [VANDF]
Common Name English
SODIUM HYDROXIDE [HSDB]
Common Name English
STAMPERPREP
Common Name English
SODIUM HYDROXIDE [INCI]
Common Name English
E-524
Code English
SODIUM HYDROXIDE [WHO-IP]
Common Name English
NATRII HYDROXYDUM [WHO-IP LATIN]
Common Name English
SODIUM HYDROXIDE [II]
Common Name English
Sodium hydroxide [WHO-DD]
Common Name English
SODIUM HYDRATE
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 184.1763
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
EPA PESTICIDE CODE 75603
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
JECFA EVALUATION INS-524
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
NCI_THESAURUS C802
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-524
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
Code System Code Type Description
EVMPD
SUB50077
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105794
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
CAS
1310-73-2
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
MESH
D008191
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
HSDB
229
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
CHEBI
32145
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
DRUG BANK
DB11151
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
EVMPD
SUB12585MIG
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-185-5
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
DAILYMED
55X04QC32I
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID0029634
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
PUBCHEM
14798
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SODIUM HYDROXIDE
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY Description. White or almost white, fused masses, sticks, pellets, or flakes; they are hard and brittle, showing a crystalline fracture. Solubility: Very soluble in water and ethanol (~750 g/l) TS. Category: Alkalinizing agent; used in the preparation of sodium lactate solution. Storage: Sodium hydroxide should be kept in a tightly closed container. Additional information: CAUTION: Sodium hydroxide must be handled with care, avoiding contact with the skin. It is very deliquescent, strongly alkaline, and corrosive. It rapidly absorbs carbon dioxide. Requirement: Sodium hydroxide contains not less than 97.5% of total alkali, calculated as NaOH, and not more than the equivalent of 2.5% of Na2CO3.
NSC
135799
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
RXCUI
9880
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
4636
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
NCI_THESAURUS
C74373
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
WIKIPEDIA
SODIUM HYDROXIDE
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
MESH
D012972
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
MERCK INDEX
m10031
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY Merck Index
FDA UNII
55X04QC32I
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
SMS_ID
100000090202
Created by admin on Sat Dec 16 20:10:08 GMT 2023 , Edited by admin on Sat Dec 16 20:10:08 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of HYDROXIDE ION
SUBSTANCE RECORD
Structure of Sodium hydroxide
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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