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Details

Stereochemistry ACHIRAL
Molecular Formula Na.HO
Molecular Weight 39.9971
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM HYDROXIDE

SMILES

[Na+].[OH-]

InChI

InChIKey=HEMHJVSKTPXQMS-UHFFFAOYSA-M
InChI=1S/Na.H2O/h;1H2/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

1279152000000
Primary
Primary
Primary
Primary
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

-365299200000
PubMed

PubMed

TitleDatePubMed
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
1972
Delayed cystitis due to cyclophosphamide.
1979 Jan 4
A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k.
1993 Mar 30
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 Dec 20
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
1994 Dec 20
Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.
1994 Sep 30
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997 Aug 15
Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.
1997 Feb
One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation.
1997 Feb 15
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
1997 Nov
Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1.
1998 Jun
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
1998 Mar 6
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Effect of beta-blockers on free radical-induced cardiac contractile dysfunction.
1999 Jul 27
Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals.
2001 Dec 5
Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions.
2001 Jun
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.
2001 Mar 1
Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1.
2001 Oct 5
Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress.
2003 Dec 19
Interactions of growth inhibitory factor with hydroxyl and superoxide radicals.
2003 Sep
Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction.
2004 Jan
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
2005 Feb 18
Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.
2006 Feb
The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first?
2006 Oct 30
Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions.
2007 Dec
Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.
2007 Jun 1
Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney.
2007 May
A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell.
2009 Feb
Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis.
2009 Jul
Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds.
2009 Jul 10
Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata).
2009 Nov
Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla).
2009 Sep 1
Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.
2010 Apr 21
Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance.
2010 Aug 1
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
2010 Sep 6
Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus.
2011 Apr
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.
2011 Apr 1
Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken.
2011 Jan
Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes.
2011 Mar
Identification and characterization of functional aquaporin water channel protein from alimentary tract of whitefly, Bemisia tabaci.
2011 Mar
Water permeability and characterization of aquaporin-11.
2011 May
Inhibition of aquaporin-3 water channel in the colon induces diarrhea.
2012
Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.
2012 Apr
Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation.
2012 Feb 1
Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells.
2012 Jun
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
2012 Jun 1
A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.
2012 May
Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD).
2012 Sep
Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity.
2013 Aug 14
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
2013 Feb
Patents

Sample Use Guides

10% Potassium Hydroxide
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:20:12 UTC 2021
Edited
by admin
on Fri Jun 25 21:20:12 UTC 2021
Record UNII
55X04QC32I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM HYDROXIDE
EP   FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
INS-524
Code English
SODIUM HYDROXIDE [EP MONOGRAPH]
Common Name English
SODIUM HYDROXIDE [MI]
Common Name English
CAUSTIC SODA
Common Name English
SODIUM HYDROXIDE [JAN]
Common Name English
LYE
Common Name English
PROMOTER 3308B
Brand Name English
SODIUM HYDROXIDE SOLUTIONS [FCC]
Common Name English
SODIUM HYDROXIDE SOLUTIONS
FCC  
Common Name English
AETZNATRON
Common Name English
TOSOH PEARL
Brand Name English
NSC-135799
Code English
SODIUM HYDROXIDE [FCC]
Common Name English
SODIUM HYDROXIDE [MART.]
Common Name English
SODIUM HYDROXIDE [VANDF]
Common Name English
SODIUM HYDROXIDE [HSDB]
Common Name English
STAMPERPREP
Common Name English
SODIUM HYDROXIDE [INCI]
Common Name English
E-524
Code English
SODIUM HYDROXIDE [WHO-IP]
Common Name English
NATRII HYDROXYDUM [WHO-IP LATIN]
Common Name English
SODIUM HYDROXIDE [WHO-DD]
Common Name English
SODIUM HYDROXIDE [II]
Common Name English
SODIUM HYDRATE
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 184.1763
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
EPA PESTICIDE CODE 75603
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
JECFA EVALUATION INS-524
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
NCI_THESAURUS C802
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-524
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
Code System Code Type Description
EVMPD
SUB50077
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
ChEMBL
CHEMBL2105794
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
CAS
1310-73-2
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
MESH
D008191
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
HSDB
229
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
DRUG BANK
DB11151
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
EVMPD
SUB12585MIG
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
ECHA (EC/EINECS)
215-185-5
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
EPA CompTox
1310-73-2
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
JECFA MONOGRAPH
INS-524
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
PUBCHEM
14798
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SODIUM HYDROXIDE
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY Description. White or almost white, fused masses, sticks, pellets, or flakes; they are hard and brittle, showing a crystalline fracture. Solubility: Very soluble in water and ethanol (~750 g/l) TS. Category: Alkalinizing agent; used in the preparation of sodium lactate solution. Storage: Sodium hydroxide should be kept in a tightly closed container. Additional information: CAUTION: Sodium hydroxide must be handled with care, avoiding contact with the skin. It is very deliquescent, strongly alkaline, and corrosive. It rapidly absorbs carbon dioxide. Requirement: Sodium hydroxide contains not less than 97.5% of total alkali, calculated as NaOH, and not more than the equivalent of 2.5% of Na2CO3.
RXCUI
9880
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
4636
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
NCI_THESAURUS
C74373
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
WIKIPEDIA
SODIUM HYDROXIDE
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
MESH
D012972
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY
MERCK INDEX
M10031
Created by admin on Fri Jun 25 21:20:13 UTC 2021 , Edited by admin on Fri Jun 25 21:20:13 UTC 2021
PRIMARY Merck Index
FDA UNII
55X04QC32I
Created by admin on Fri Jun 25 21:20:12 UTC 2021 , Edited by admin on Fri Jun 25 21:20:12 UTC 2021
PRIMARY
Related Record Type Details
ACTIVE MOIETY