Dapsone was synthesized in 1908 by Fromm and Wittmann. The drug was approved by FDA for the treatment of such conditions as acne vulgaris, leprosy and dermatitis herpetiformis, also the drug is used off-label for many skin diseases. Although the exact mechanism of dapsone action is unknown, it is speculated that it acts as both anti-inflammatory and antimicrobial agent. It was demonstrated that dapsone suppresses ROS generation, inhibits neutrophil myeloperoxidase and eosinophil peroxidase and also inhibits bacterial dihydropteroate synthase.

4,4'-Thiodianiline is a chemical intermediate that was used in a production of mordant yellow and other dyes. 4,4'-Thiodianiline is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. 4,4'-Thiodianiline has demonstrated anticonvulsant activity in vivo.

Methyl chloride, also called chloromethane, mainly is used as a refrigerant. It’s known, that methyl chloride permeates through human epidermis when exposed at high atmospheric concentrations within relatively short timeframes. Recently published article has shown that chlorinated methyl group could be formed in humans, that might be an important target compound in future medical diagnostic programs.