4,4'-THIODIANILINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H12N2S
Molecular Weight	216.302
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=CC=C(SC2=CC=C(N)C=C2)C=C1

InChI

InChIKey=ICNFHJVPAJKPHW-UHFFFAOYSA-N

InChI=1S/C12H12N2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,13-14H2

HIDE SMILES / InChI

Molecular Formula	C12H12N2S
Molecular Weight	216.302
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21863124 | https://www.ncbi.nlm.nih.gov/pubmed/19632831

4,4'-Thiodianiline is a chemical intermediate that was used in a production of mordant yellow and other dyes. 4,4'-Thiodianiline is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. 4,4'-Thiodianiline has demonstrated anticonvulsant activity in vivo.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Epilepsy 121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19632831	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens.	2005 Mar 1	15710170
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.	2009 Sep 1	19632831

Patents

Sample Use Guides

In Vivo Use Guide

In a model of epilepsy, the compound was administered to rats intraperitoneally at 30 mg/kg

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:59:21 GMT 2023` Edited by `admin` on `Fri Dec 15 15:59:21 GMT 2023`
Record UNII	6GGU990BQF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

4,4'-THIODIANILINE

Systematic Name

English

BENZENAMINE, 4,4'-THIOBIS-

Systematic Name

English

4,4'-THIODIANILINE [IARC]

Common Name

English

BAPS

Common Name

English

4,4'-THIOBISBENZENAMINE

Systematic Name

English

BIS(P-AMINOPHENYL) SULFIDE

Common Name

English

DI(P-AMINOPHENYL) SULFIDE

Common Name

English

NSC-6191

Code

English

4,4'-THIODIANILINE [HSDB]

Common Name

English

P,P'-DIAMINODIPHENYL SULFIDE

Common Name

English

NCI-C01707

Code

English

Code System Code Type Description

NCI_THESAURUS

C44322