Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H12N2O3S |
Molecular Weight | 264.3 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(NO)C=C2
InChI
InChIKey=IYDSJDWESCGRKW-UHFFFAOYSA-N
InChI=1S/C12H12N2O3S/c13-9-1-5-11(6-2-9)18(16,17)12-7-3-10(14-15)4-8-12/h1-8,14-15H,13H2
Molecular Formula | C12H12N2O3S |
Molecular Weight | 264.3 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia. | 1988 Jan |
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Dapsone-induced hemolytic anemia: effect of dapsone hydroxylamine on sulfhydryl status, membrane skeletal proteins and morphology of human and rat erythrocytes. | 1995 Jul |
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Dapsone-induced hemolytic anemia: role of glucose-6-phosphate dehydrogenase in the hemolytic response of rat erythrocytes to N-hydroxydapsone. | 1995 May |
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Oxidative stress, glucose-6-phosphate dehydrogenase and the red cell. | 2001 |
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Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. | 2005 May 27 |
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Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents. | 2005 Nov |
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Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells. | 2007 Apr |
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Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver. | 2008 Aug 1 |
Substance Class |
Chemical
Created
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Edited
Sat Dec 16 11:05:17 GMT 2023
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Record UNII |
GS5815Z51W
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Record Status |
Validated (UNII)
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Record Version |
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Related Record | Type | Details | ||
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METABOLITE -> PARENT |
We have also shown recently that greater than 90% of dapsone hydroxylation in human liver microsomes is undertaken by cytochrome P4503A4
URINE
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PARENT -> METABOLITE TOXIC |
Metabolite known for methaemoglobin formation in man.
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