DAPSONE HYDROXYLAMINE

NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(NO)C=C2

InChIKey=IYDSJDWESCGRKW-UHFFFAOYSA-N

InChI=1S/C12H12N2O3S/c13-9-1-5-11(6-2-9)18(16,17)12-7-3-10(14-15)4-8-12/h1-8,14-15H,13H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver.	2008-08-01	18602405
Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells.	2007-04	17220235
Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents.	2005-11	16107547
Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes.	2005-05-27	15862605
The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283).	2004-12	15592329
Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.	2003-02-01	12559973
Oxidative stress, glucose-6-phosphate dehydrogenase and the red cell.	2001	11765001
Dapsone-induced hemolytic anemia: effect of dapsone hydroxylamine on sulfhydryl status, membrane skeletal proteins and morphology of human and rat erythrocytes.	1995-07	7616443
Dapsone-induced hemolytic anemia: role of glucose-6-phosphate dehydrogenase in the hemolytic response of rat erythrocytes to N-hydroxydapsone.	1995-05	7752092
Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia.	1988-01	3335994
Evaluation of the sulfones and streptomycin in experimental tuberculosis.	1949-12-14	15398779

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:37:54 GMT 2025` Edited by `admin` on `Mon Mar 31 23:37:54 GMT 2025`
Record UNII	GS5815Z51W
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

N-HYDROXYDAPSONE

Preferred Name

English

DAPSONE HYDROXYLAMINE

Common Name

English

BENZENAMINE, 4-((4-AMINOPHENYL)SULFONYL)-N-HYDROXY-

Systematic Name

English

NSC-742234

Code

English

N-HYDROXY-4,4'-SULFONYLDI(ANILINE)

Systematic Name

English

4-(HYDROXYAMINO)-4'-AMINODIPHENYL SULFONE

Systematic Name

English

Code System Code Type Description

NSC

742234